Results 31 to 40 of about 10,433 (192)

Development of a multi-route physiologically based pharmacokinetic (PBPK) model for nanomaterials: a comparison between a traditional versus a new route-specific approach using gold nanoparticles in rats

Particle and Fibre Toxicology, 2022
Background Physiologically based pharmacokinetic (PBPK) modeling is an important tool in predicting target organ dosimetry and risk assessment of nanoparticles (NPs).
Wei-Chun Chou, Yi-Hsien Cheng, Jim E. Riviere, Nancy A. Monteiro-Riviere, Wolfgang G. Kreyling, Zhoumeng Lin   +5 more
doaj   +1 more source

Physiologically based modeling and prediction of drug interactions [PDF]

, 2010
International audienceA major challenge for drug development and environmental or occupational health is the prediction of pharmacokinetic and pharmacodynamic interactions between drugs, natural chemicals or environmental contaminants.
Bois, Frédéric Y.
core   +3 more sources

Physiologically-Based Pharmacokinetic (PBPK) Modeling Providing Insights into Fentanyl Pharmacokinetics in Adults and Pediatric Patients

Pharmaceutics, 2020
Fentanyl is widely used for analgesia, sedation, and anesthesia both in adult and pediatric populations. Yet, only few pharmacokinetic studies of fentanyl in pediatrics exist as conducting clinical trials in this population is especially challenging ...
Lukas Kovar, Andreas Weber, Michael Zemlin, Yvonne Kohl, Robert Bals, Bernd Meibohm, Dominik Selzer, Thorsten Lehr   +7 more
doaj   +1 more source

Adapting physiologically-based pharmacokinetic models for machine learning applications

Scientific Reports, 2023
Both machine learning and physiologically-based pharmacokinetic models are becoming essential components of the drug development process. Integrating the predictive capabilities of physiologically-based pharmacokinetic (PBPK) models within machine ...
Sohaib Habiballah, Brad Reisfeld
doaj   +1 more source

Model reduction in mathematical pharmacology: integration, reduction and linking of PBPK and systems biology models [PDF]

, 2018
In this paper we present a framework for the reduction and linking of physiologically based pharmacokinetic (PBPK) models with models of systems biology to describe the effects of drug administration across multiple scales.
Snowden, Thomas J., Tindall, Marcus J., van der Graaf, Piet H.   +2 more
core   +1 more source

PRT to predict pharmacokinetic profiles as part of a bioequivalence study of the drug deferasirox

Разработка и регистрация лекарственных средств
Introduction. Deferasirox is a complexing drug and belongs to class II according to the biopharmaceutical classification system (BCS), has acidic properties and belongs to subclass “a” (acid).
A. V. Suvorova, P. A. Losenkova, Yu. V. Medvedev, E. A. Malashenko, I. E. Makarenko, A. M. Poluyanov, I. E. Shohin   +6 more
doaj   +1 more source

Guide to development of compound files for PBPK modeling in the Simcyp population‐based simulator

CPT: Pharmacometrics & Systems Pharmacology, 2022
The Simcyp Simulator is a software platform for population physiologically‐based pharmacokinetic (PBPK) modeling and simulation. It links in vitro data to in vivo absorption, distribution, metabolism, excretion and pharmacokinetic/pharmacodynamic ...
Udoamaka Ezuruike, Mian Zhang, Amita Pansari, Mailys De Sousa Mendes, Xian Pan, Sibylle Neuhoff, Iain Gardner   +6 more
doaj   +1 more source

Developing a Physiologically-Based Pharmacokinetic Model Knowledgebase in Support of Provisional Model Construction.

PLoS Computational Biology, 2016
Developing physiologically-based pharmacokinetic (PBPK) models for chemicals can be resource-intensive, as neither chemical-specific parameters nor in vivo pharmacokinetic data are easily available for model construction.
Jingtao Lu, Michael-Rock Goldsmith, Christopher M Grulke, Daniel T Chang, Raina D Brooks, Jeremy A Leonard, Martin B Phillips, Ethan D Hypes, Matthew J Fair, Rogelio Tornero-Velez, Jeffre Johnson, Curtis C Dary, Yu-Mei Tan   +12 more
doaj   +1 more source

Physiologically Based Pharmacokinetic Modeling of Cefadroxil in Mouse, Rat, and Human to Predict Concentration–Time Profile at Infected Tissue

Frontiers in Pharmacology, 2021
The aim of this study was to develop physiologically based pharmacokinetic (PBPK) models capable of simulating cefadroxil concentrations in plasma and tissues in mouse, rat, and human.
Zhongxia Tan, Youxi Zhang, Chao Wang, Le Sun   +3 more
doaj   +1 more source

SISO APP Searches in Lattices with Tanner Graphs

, 2011
An efficient, low-complexity, soft-output detector for general lattices is presented, based on their Tanner graph (TG) representations. Closest-point searches in lattices can be performed as non-binary belief propagation on associated TGs; soft ...
Ionescu, Dumitru Mihai, Zhu, Haidong
core   +1 more source