Simulated rat intestinal fluid improves oral exposure prediction for poorly soluble compounds over a wide dose range [PDF]
, 2016 Solubility can be the absorption limiting factor for drug candidates and is therefore a very important input parameter for oral exposure prediction of compounds with limited solubility.
Bernard Faller +3 more
core +3 more sources
Physiologically Based Pharmacokinetic (PBPK) Models for Ethanol [PDF]
IEEE Transactions on Biomedical Engineering, 2008 Physiologically based pharmacokinetic models have been used to describe the distribution and elimination of ethanol after intravenous administration. These models have been used to estimate the ethanol infusion profile that is sufficient for achieving a prescribed breath ethanol concentration time course in individuals, providing a useful platform for ...
Martin H, Plawecki +4 more
openaire +2 more sources
Physiologically based modeling and prediction of drug interactions [PDF]
, 2010 International audienceA major challenge for drug development and environmental or occupational health is the prediction of pharmacokinetic and pharmacodynamic interactions between drugs, natural chemicals or environmental contaminants.
Bois, Frédéric Y.
core +3 more sources
Model reduction in mathematical pharmacology: integration, reduction and linking of PBPK and systems biology models [PDF]
, 2018 In this paper we present a framework for the reduction and linking of physiologically based pharmacokinetic (PBPK) models with models of systems biology to describe the effects of drug administration across multiple scales.
Snowden, Thomas J. +2 more
core +1 more source
Virtual bioequivalence for achlorhydric subjects: The use of PBPK modelling to assess the formulation-dependent effect of achlorhydria [PDF]
, 2017 Majority of bioequivalence studies are conducted in healthy volunteers. It has been argued that bioequivalence may not necessarily hold true in relevant patient populations due to a variety of reasons which affect one formulation more than the other for ...
Darwich Adam S. +4 more
core +1 more source
Physiologically Based Pharmacokinetic Virtual Twin Approach for Fludarabine Dosing in Pediatric Hematopoietic Stem Cell Transplantation. [PDF]
CPT Pharmacometrics Syst PharmacolABSTRACT Fludarabine (Flu), administered as a prodrug Flu monophosphate, is a lymphodepleting agent used prior to hematopoietic stem cell transplantation (HSCT) which exhibits substantial pharmacokinetics (PK) variability, contributing to suboptimal outcomes.
Mseddi M +9 more
europepmc +2 more sources
An Overview of Physiologically-Based Pharmacokinetic Models for Forensic Science
Toxics, 2023 A physiologically-based pharmacokinetic (PBPK) model represents the structural components of the body with physiologically relevant compartments connected via blood flow rates described by mathematical equations to determine drug disposition. PBPK models
Kiara Fairman +6 more
doaj +1 more source
Human Food Safety Implications of Variation in Food Animal Drug Metabolism [PDF]
, 2016 Citation: Lin, Z., Vahl, C. I., & Riviere, J. E. (2016). Human Food Safety Implications of Variation in Food Animal Drug Metabolism. Scientific Reports, 6.
Lin, Zhoumeng +2 more
core +1 more source
Modelling and PBPK Simulation in Drug Discovery [PDF]
The AAPS Journal, 2009 Physiologically based pharmacokinetic (PBPK) models are composed of a series of differential equations and have been implemented in a number of commercial software packages. These models require species-specific and compound-specific input parameters and allow for the prediction of plasma and tissue concentration time profiles after intravenous and ...
Hannah M, Jones +2 more
openaire +2 more sources
Modélisation physiologique des interactions métaboliques [PDF]
, 2009 National audienceModeling metabolic interactions between chemicals can be a task of formidable complexity. Here I present a new approach and new tools to facilitate that development.
Bois, Frédéric Y.
core +3 more sources