Results 31 to 40 of about 16,022 (277)
Pharmaceutics, 2019 The physiologically based pharmacokinetic (PBPK) approach facilitates the construction of novel drug−disease models by allowing incorporation of relevant pathophysiological changes.
Muhammad F. Rasool +7 more
doaj +1 more source
Normal Numbers and the Borel Hierarchy [PDF]
, 2013 We show that the set of absolutely normal numbers is $\mathbf \Pi^0_3$-complete in the Borel hierarchy of subsets of real numbers.
Becher, Verónica +2 more
core +3 more sources
Gates Open Research, 2023 Physiologically based pharmacokinetic (PBPK) models represent computational technology to characterize drug behavior within the context of detailed human physiology.
Jolien Freriksen +10 more
doaj +1 more source
Evaluation of the PK/PD Changes on MASLD-Related Population-An Example From Simultaneous Acetaminophen Parent-Metabolite PBPK/PD Modeling. [PDF]
CPT Pharmacometrics Syst PharmacolABSTRACT Patients with metabolic dysfunction‐associated steatotic liver disease (MASLD) may exhibit altered pharmacokinetics (PK) and pharmacodynamics (PD) of drugs compared with healthy populations. However, no physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) model has been specifically developed for MASLD.
Zhao S, Zhang L.
europepmc +2 more sources
Comparison of Subjective Responses to Oral and Intravenous Alcohol Administration under Similar Systemic Exposures [PDF]
, 2019 Objective To test whether an individual's subjective responses to alcohol are similar when the breath alcohol concentration (BrAC) trajectory resulting from oral administration is matched by intravenous administration.
Boes, Julian +6 more
core +1 more source
Model-Informed Precision Dosing of Antibiotics in Osteoarticular Infections
Infection and Drug Resistance, 2022 Lingling Liu,1 Jin Wang,1 Huan Zhang,1 Mengli Chen,2 Yun Cai1 1Center of Medicine Clinical Research, Department of Pharmacy, Medical Supplies Center, PLA General Hospital, Beijing, People’s Republic of China; 2Department of Pharmacy, Medical Supplies ...
Liu L, Wang J, Zhang H, Chen M, Cai Y
doaj
CPT: Pharmacometrics & Systems Pharmacology, 2023 The pharmacokinetics (PKs) and safety of medications in particular groups can be predicted using the physiologically‐based pharmacokinetic (PBPK) model.
Xu Zhou +5 more
doaj +1 more source
Tingkat Parasitasi Parasitoid Telur Pbpk pada Pertanaman Padi dengan Beberapa Ketinggian Tempat Berbeda [PDF]
, 2016 Rice is the staple food of Indonesia's population. Various problems occur in an effort to increase production and productivity. One problem is the attack of yellow rice stem borer (PBPK) which may result in yield losses up to 90%.
Resiani, N. M. (Ni)
core +1 more source
Physiologically Based Pharmacokinetic (PBPK) Models for Ethanol [PDF]
IEEE Transactions on Biomedical Engineering, 2008 Physiologically based pharmacokinetic models have been used to describe the distribution and elimination of ethanol after intravenous administration. These models have been used to estimate the ethanol infusion profile that is sufficient for achieving a prescribed breath ethanol concentration time course in individuals, providing a useful platform for ...
Martin H, Plawecki +4 more
openaire +2 more sources
Physiologically-Based Pharmacokinetic Modeling of the PARP Inhibitor Niraparib. [PDF]
CPT Pharmacometrics Syst PharmacolABSTRACT A physiologically‐based pharmacokinetic (PBPK) model of niraparib and its primary metabolite using a relevant virtual cancer population is reported here. A series of in vitro experiments using liver S9, microsomes, and hepatocytes with various inhibitors and recombinant supersomes demonstrated that niraparib is specifically metabolized by ...
Lewis GJ +3 more
europepmc +2 more sources