Results 51 to 60 of about 14,363 (238)
British Journal of Clinical Pharmacology, EarlyView.While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis +5 more
wiley +1 more source
PBPK Modeling on Organs-on-Chips: An Overview of Recent Advancements
Frontiers in Bioengineering and Biotechnology, 2022 Organ-on-a-chip (OoC) is a new and promising technology, which aims to improve the efficiency of drug development and realize personalized medicine by simulating in vivo environment in vitro.
Yi Yang +9 more
doaj +1 more source
Cutting Edge PBPK Models and Analyses: Providing the Basis for Future Modeling Efforts and Bridges to Emerging Toxicology Paradigms [PDF]
, 2012 Physiologically based Pharmacokinetic (PBPK) models are used for predictions of internal or target dose from environmental and pharmacologic chemical exposures.
Jane C. Caldwell +2 more
core +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aims To translate a PBPK model developed for the direct oral anticoagulant, dabigatran etexilate, the prodrug of dabigatran, based on data obtained from healthy men to healthy non‐pregnant, pregnant and post‐partum women. To evaluate safety and efficacy of dabigatran etexilate in post‐partum women using simulations and design a future clinical study to
Kayode Ogungbenro +3 more
wiley +1 more source
SISO APP Searches in Lattices with Tanner Graphs
, 2011 An efficient, low-complexity, soft-output detector for general lattices is presented, based on their Tanner graph (TG) representations. Closest-point searches in lattices can be performed as non-binary belief propagation on associated TGs; soft ...
Ionescu, Dumitru Mihai, Zhu, Haidong
core +1 more source
VÝUKOVÝ MATERIÁL NAD NADSTAVBOVOU PLATFORMOU PBPK
Medsoft, 2021 Oblast Physiological Based Pharmacokinetic (PBPK) modelování je stále důležitější ve všech oborech medicíny. Existuje řada knih a materiálů popisujících problematiku PBPK modelování z různých úhlů. Není však zcela dostupný materiál, který by vytvářel výukové podklady pro všechny zapojené skupiny v odpovídající komplexnosti.
Michal Huptych +2 more
openaire +1 more source
Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics
British Journal of Clinical Pharmacology, EarlyView.Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay +5 more
wiley +1 more source
CPT: Pharmacometrics & Systems Pharmacology, 2023 This report summarizes the proceedings for day 2 sessions 1 and 3 of the 2‐day public workshop entitled “Regulatory Utility of Mechanistic Modeling to Support Alternative Bioequivalence Approaches,” a jointly sponsored workshop by the US Food and Drug ...
Fang Wu +17 more
doaj +1 more source
Frontiers in Pharmacology, 2021 The aim of this study was to develop physiologically based pharmacokinetic (PBPK) models capable of simulating cefadroxil concentrations in plasma and tissues in mouse, rat, and human.
Zhongxia Tan +3 more
doaj +1 more source
HD Physiology Project-Japanese efforts to promote multilevel integrative systems biology and physiome research. [PDF]
, 2017 The HD Physiology Project is a Japanese research consortium that aimed to develop methods and a computational platform in which physiological and pathological information can be described in high-level definitions across multiple scales of time and size.
for HD physiology project investigators +3 more
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