Results 51 to 60 of about 16,022 (277)
Human Food Safety Implications of Variation in Food Animal Drug Metabolism [PDF]
, 2016 Citation: Lin, Z., Vahl, C. I., & Riviere, J. E. (2016). Human Food Safety Implications of Variation in Food Animal Drug Metabolism. Scientific Reports, 6.
Lin, Zhoumeng +2 more
core +1 more source
PLoS Computational Biology, 2016 Developing physiologically-based pharmacokinetic (PBPK) models for chemicals can be resource-intensive, as neither chemical-specific parameters nor in vivo pharmacokinetic data are easily available for model construction.
Jingtao Lu +12 more
doaj +1 more source
PBPK modelling of inter-individual variability in the pharmacokinetics of environmental chemicals [PDF]
, 2010 International audienceGeneric PBPK models, applicable to a large number of substances, coupled to parameter databases and QSAR modules, are now available for predictive modelling of inter-individual variability in the absorption, distribution, metabolism
Bois, Frédéric Y. +2 more
core +2 more sources
Pharmaceutics, 2020 Fentanyl is widely used for analgesia, sedation, and anesthesia both in adult and pediatric populations. Yet, only few pharmacokinetic studies of fentanyl in pediatrics exist as conducting clinical trials in this population is especially challenging ...
Lukas Kovar +7 more
doaj +1 more source
Guide to development of compound files for PBPK modeling in the Simcyp population‐based simulator
CPT: Pharmacometrics & Systems Pharmacology, 2022 The Simcyp Simulator is a software platform for population physiologically‐based pharmacokinetic (PBPK) modeling and simulation. It links in vitro data to in vivo absorption, distribution, metabolism, excretion and pharmacokinetic/pharmacodynamic ...
Udoamaka Ezuruike +6 more
doaj +1 more source
Pharmacokinetics of teicoplanin in paediatric patients—A systematic review of current literature
British Journal of Clinical Pharmacology, EarlyView.Background and Objective Teicoplanin is commonly used in children to treat gram‐positive infections and is sometimes used off‐label prophylactically in surgical or paediatric oncology settings. The pharmacokinetics (PK) of teicoplanin in children exhibit considerable variability, such as in critically ill children or those with renal impairment.
Noa E. Wijnen +4 more
wiley +1 more source
PBPK Modeling on Organs-on-Chips: An Overview of Recent Advancements
Frontiers in Bioengineering and Biotechnology, 2022 Organ-on-a-chip (OoC) is a new and promising technology, which aims to improve the efficiency of drug development and realize personalized medicine by simulating in vivo environment in vitro.
Yi Yang +9 more
doaj +1 more source
Translocation of gold nanoparticles across the lung epithelial tissue barrier: Combining in vitro and in silico methods to substitute in vivo experiments [PDF]
, 2015 The lung epithelial tissue barrier represents the main portal for entry of inhaled nanoparticles (NPs) into the systemic circulation. Thus great efforts are currently being made to determine adverse health effects associated with inhalation of NPs ...
Bachler, Gerald +7 more
core +1 more source
British Journal of Clinical Pharmacology, EarlyView.While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis +5 more
wiley +1 more source
Adapting physiologically-based pharmacokinetic models for machine learning applications
Scientific Reports, 2023 Both machine learning and physiologically-based pharmacokinetic models are becoming essential components of the drug development process. Integrating the predictive capabilities of physiologically-based pharmacokinetic (PBPK) models within machine ...
Sohaib Habiballah, Brad Reisfeld
doaj +1 more source