Results 11 to 20 of about 12,660 (249)

Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model [PDF]

CPT: Pharmacometrics & Systems Pharmacology, 2016
The aim of this tutorial is to introduce the fundamental concepts of physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) modeling with a special focus on their practical implementation in a typical PBPK model building workflow. To illustrate basic steps in PBPK model building, a PBPK model for ciprofloxacin will be constructed and coupled ...
Kuepfer, L, Niederalt, C, Wendl, T, Schlender, J‐F, Willmann, S, Lippert, J, Block, M, Eissing, T, Teutonico, D   +8 more
openaire   +4 more sources

Physiologically Based Pharmacokinetic (PBPK) Model of Gold Nanoparticle-Based Drug Delivery System for Stavudine Biodistribution. [PDF]

Pharmaceutics, 2022
Zazo H, Colino CI, Gutiérrez-Millán C, Cordero AA, Bartneck M, Lanao JM.   +5 more
europepmc   +2 more sources

Prediction for optimal dosage of pazopanib under various clinical situations using physiologically based pharmacokinetic modeling

Frontiers in Pharmacology, 2022
This study aimed to apply a physiologically based pharmacokinetic (PBPK) model to predict optimal dosing regimens of pazopanib (PAZ) for safe and effective administration when co-administered with CYP3A4 inhibitors, acid-reducing agents, food, and ...
Chunnuan Wu, Chunnuan Wu, Chunnuan Wu, Bole Li, Bole Li, Bole Li, Shuai Meng, Shuai Meng, Shuai Meng, Linghui Qie, Linghui Qie, Linghui Qie, Jie Zhang, Jie Zhang, Jie Zhang, Guopeng Wang, Cong Cong Ren   +16 more
doaj   +1 more source

A PBPK model recapitulates early kinetics of anti-PEG antibody-mediated clearance of PEG-liposomes. [PDF]

J Control Release, 2022
Talkington AM, McSweeney MD, Wessler T, Rath MK, Li Z, Zhang T, Yuan H, Frank JE, Forest MG, Cao Y, Lai SK.   +10 more
europepmc   +2 more sources

Population variability in animal health: Influence on dose-exposure-response relationships: Part II: Modelling and simulation [PDF]

, 2018
During the 2017 Biennial meeting, the American Academy of Veterinary Pharmacology and Therapeutics hosted a 1‐day session on the influence of population variability on dose‐exposure‐response relationships. In Part I, we highlighted some of the sources of
Bailey, Bon, Cox, Darwich, Dorey, Duwal, Ette, Fink, Jamei, Jamei, Jeunesse, Li, Li, Lin, Maaland, Margolskee, Margolskee, Martinez, Martinez, Martinez, Mochel, Mochel, Mochel, Mochel, Mochel, Mould, Ogungbenro, Pade, Pade, Paulson, Pelligand, Rey, Rostami-Hodjegan, Sheiner, Silber, Sjögren, Toutain, Tsamandouras, T’jollyn, Willmann, Zhuang   +40 more
core   +7 more sources

Adapting physiologically-based pharmacokinetic models for machine learning applications

Scientific Reports, 2023
Both machine learning and physiologically-based pharmacokinetic models are becoming essential components of the drug development process. Integrating the predictive capabilities of physiologically-based pharmacokinetic (PBPK) models within machine ...
Sohaib Habiballah, Brad Reisfeld
doaj   +1 more source

Reviewing Data Integrated for PBPK Model Development to Predict Metabolic Drug-Drug Interactions: Shifting Perspectives and Emerging Trends. [PDF]

Front Pharmacol, 2021
Abouir K, Samer CF, Gloor Y, Desmeules JA, Daali Y.   +4 more
europepmc   +2 more sources

Physiology-based IVIVE predictions of tramadol from in vitro metabolism data [PDF]

, 2014
To predict the tramadol in vivo pharmacokinetics in adults by using in vitro metabolism data and an in vitro-in vivo extrapolation (IVIVE)-linked physiologically-based pharmacokinetic (PBPK) modeling and simulation approach (SimcypA (R)).
Allegaert, Karel, Annaert, Pieter, Boussery, Koen, Colin, Pieter, Cuyckens, Filip, Mannens, Geert, Snoeys, Jan, T'jollyn, Huybrecht, Van Bocxlaer, Jan, Van Peer, Achiel, Vermeulen, An   +10 more
core   +1 more source

Recent Progress on Physiologically Based Pharmacokinetic (PBPK) Model: A Review Based on Bibliometrics. [PDF]

Toxics
Huang H, Zhao W, Qin N, Duan X.
europepmc   +2 more sources

PBPK model reporting template for chemical risk assessment applications. [PDF]

Regul Toxicol Pharmacol, 2020
Tan YM, Chan M, Chukwudebe A, Domoradzki J, Fisher J, Hack CE, Hinderliter P, Hirasawa K, Leonard J, Lumen A, Paini A, Qian H, Ruiz P, Wambaugh J, Zhang F, Embry M.   +15 more
europepmc   +2 more sources