Results 211 to 220 of about 12,447 (257)

A PBPK model for midazolam in four avian species

Journal of Veterinary Pharmacology and Therapeutics, 2009
A physiologically based pharmacokinetic (PBPK) model was developed for midazolam in the chicken and extended to three other species. Physiological parameters included organ weights obtained from 10 birds of each species and blood flows obtained from the literature. Partition coefficients for midazolam in tissues vs.
K A, Cortright, S E, Wetzlich, A L, Craigmill   +2 more
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Assessing interindividual variability by Bayesian-PBPK modeling

Drug Discovery Today: Disease Models, 2016
The description of interindividual variability and the ADME-related sources of such variability (ADME: absorption, distribution, metabolization, excretion) is an essential element in clinical drug development to identify potentially relevant subgroups of non-responders or high-risk patients.
Markus Krauss, Andreas Schuppert
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Chlorpyrifos PBPK/PD model for multiple routes of exposure

Xenobiotica, 2014
1. Chlorpyrifos (CPF) is an important pesticide used to control crop insects. Human Exposures to CPF will occur primarily through oral exposure to residues on foods. A physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) model has been developed that describes the relationship between oral, dermal and inhalation doses of CPF and key events ...
Torka S, Poet, Charles, Timchalk, Jon A, Hotchkiss, Michael J, Bartels   +3 more
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Probabilistic dose–response modeling: Case study using dichloromethane PBPK model results

Regulatory Toxicology and Pharmacology, 2007
A revised assessment of dichloromethane (DCM) has recently been reported that examines the influence of human genetic polymorphisms on cancer risks using deterministic PBPK and dose-response modeling in the mouse combined with probabilistic PBPK modeling in humans.
Dale J, Marino, Thomas B, Starr
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Rapid PBPK modeling with the httk model

2018
A Course on Physiologically Based Pharmacokinetic (PBPK) Modeling Given at ScitoVation Nov ...
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Antibody–drug conjugates: Smart chemotherapy delivery across tumor histologies

Ca-A Cancer Journal for Clinicians, 2022
Paolo Tarantino, Roberto Carmagnani Pestana, Shanu Modi   +2 more
exaly  

PBPK Model

2022
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PBPK Absorption Modeling

2022
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Sensitivity analysis of PBPK models

Toxicology Letters, 2010
G. Loizou, K. Mcnally
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Physiologically Based Pharmacokinetic (PBPK) Modelling

2022
Ankit Balhara, Sumeet Kale, Saranjit Singh   +2 more
openaire   +1 more source