Results 201 to 210 of about 8,529 (239)
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PBPK modeling of irbesartan: incorporation of hepatic uptake
Biopharmaceutics & Drug Disposition, 2015AbstractPhysiological based pharmacokinetic (PBPK) modeling is now commonly used in drug development to integrate human or animal physiological data in order to predict pharmacokinetic profiles. The aim of this work was to construct and refine a PBPK model of irbesartan taking into account its active uptake via OATP1B1/B3 in order to predict more ...
Helene, Chapy +5 more
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A PBPK model for midazolam in four avian species
Journal of Veterinary Pharmacology and Therapeutics, 2009A physiologically based pharmacokinetic (PBPK) model was developed for midazolam in the chicken and extended to three other species. Physiological parameters included organ weights obtained from 10 birds of each species and blood flows obtained from the literature. Partition coefficients for midazolam in tissues vs.
K A, Cortright +2 more
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PBPK modeling of complex hydrocarbon mixtures: gasoline
Environmental Toxicology and Pharmacology, 2004Petroleum hydrocarbon mixtures such as gasoline, diesel fuel, aviation fuel, and asphalt liquids typically contain hundreds of compounds. These compounds include aliphatic and aromatic hydrocarbons within a specific molecular weight range and sometimes lesser amounts of additives, and often exhibit qualitatively similar pharmacokinetic (PK) and ...
James E, Dennison +4 more
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Physiologically Based Pharmacokinetic (PBPK) Modeling in Children
Clinical Pharmacology & Therapeutics, 2012This review summarizes the present status of physiologically based pharmacokinetic (PBPK) modeling and simulation (M&S) and its application in support of pediatric drug research. We address the reasons that PBPK is suited to the current needs of pediatric drug development and pharmacotherapy in light of the evolution in pediatric PBPK methodologies and
J S, Barrett +3 more
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PBPK Modeling Advances Understanding of D4 Pharmacokinetics
Toxicological Sciences, 2003The article highlighted in this issue is Physiological Modeling of Inhalation Kinetics of Octamethylcyclotetrasiloxane in Humans during Rest and Exercise, by Micaela B. Reddy, Melvin E. Andersen, Paul E. Morrow, Ivan D. Dobrev, Sudarsanan Varaprath, Kathleen P. Plotzke, and Mark J. Utell (pp. 43-56).
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Development of a PBPK Model for JP-8
2006Abstract : The overarching goal of this research project was to develop a mathematical dosimetry model for aerosolized JP-8 to better understand human exposure to inhaled JP-8. The JP-8 dosimetry model could then be used to determine human health risks from exposure to JP-8. For the first time, individual hydrocarbon data were collected to characterize
Shonetta D. Gregg +2 more
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Current Pharmaceutical Design, 2009
Physiology based pharmacokinetic (PBPK) modeling and simulation is a useful method for prediction of biodistribution of both macromolecules and small molecules. It can enhance our understanding of the underlying mechanisms of biodistribution and hence may help in rational design of macromolecules used as diagnostic and therapeutic agents.
Tomi, Heiskanen +2 more
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Physiology based pharmacokinetic (PBPK) modeling and simulation is a useful method for prediction of biodistribution of both macromolecules and small molecules. It can enhance our understanding of the underlying mechanisms of biodistribution and hence may help in rational design of macromolecules used as diagnostic and therapeutic agents.
Tomi, Heiskanen +2 more
openaire +2 more sources