Results 201 to 210 of about 12,660 (249)

PBPK and Toxicokinetic Modeling

2022
Presentation to OpenTox 2022 on Sept. 16, 2022 Science Inventory, CCTE products: https://cfpub.epa.gov/si/si_public_search_results.cfm?advSearch=true&showCriteria=2&keyword=CCTE&TIMSType=&TIMSSubTypeID=&epaNumber=&ombCat=Any&dateBeginPublishedPresented=07/01/2017&dateEndPublishedPresented=&dateBeginUpdated=& ...
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QSARs for PBPK modelling of environmental contaminants

SAR and QSAR in Environmental Research, 2011
Physiologically-based pharmacokinetic (PBPK) models are increasingly finding use in risk assessment applications of data-rich compounds. However, it is a challenge to determine the chemical-specific parameters for these models, particularly in time- and resource-limiting situations.
T, Peyret, K, Krishnan
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Analysis of PBPK Models for Risk Characterization

Annals of the New York Academy of Sciences, 1999
Abstract: Adoption of a Bayesian framework for risk characterization permits the seamless integration of different kinds of information available in order to choose and parameterize risk models. It also becomes easy to disentangle uncertainty from variability, through hierarchical statistical modeling.
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Windows based general PBPK/PD modeling software

Computers in Biology and Medicine, 2008
A physiologically based pharmacokinetic (PBPK) model and program (called PostNatal) was developed which focuses on postnatal growth. Algorithms defining organ/tissue growth curves from birth through adulthood for male and female humans, dogs, rats, and mice are utilized to calculate the appropriate weight and blood flow for the internal organs/tissues.
Richard H, Luecke, Bruce A, Pearce, Walter D, Wosilait, Daniel R, Doerge, William, Slikker, John F, Young   +5 more
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PBPK modeling of complex hydrocarbon mixtures: gasoline

Environmental Toxicology and Pharmacology, 2004
Petroleum hydrocarbon mixtures such as gasoline, diesel fuel, aviation fuel, and asphalt liquids typically contain hundreds of compounds. These compounds include aliphatic and aromatic hydrocarbons within a specific molecular weight range and sometimes lesser amounts of additives, and often exhibit qualitatively similar pharmacokinetic (PK) and ...
James E, Dennison, Melvin E, Andersen, Ivan D, Dobrev, Moiz M, Mumtaz, Raymond S H, Yang   +4 more
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Physiologically Based Pharmacokinetic (PBPK) Modeling in Children

Clinical Pharmacology & Therapeutics, 2012
This review summarizes the present status of physiologically based pharmacokinetic (PBPK) modeling and simulation (M&S) and its application in support of pediatric drug research. We address the reasons that PBPK is suited to the current needs of pediatric drug development and pharmacotherapy in light of the evolution in pediatric PBPK methodologies and
J S, Barrett, O, Della Casa Alberighi, S, Läer, B, Meibohm   +3 more
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PBPK Modeling Advances Understanding of D4 Pharmacokinetics

Toxicological Sciences, 2003
The article highlighted in this issue is Physiological Modeling of Inhalation Kinetics of Octamethylcyclotetrasiloxane in Humans during Rest and Exercise, by Micaela B. Reddy, Melvin E. Andersen, Paul E. Morrow, Ivan D. Dobrev, Sudarsanan Varaprath, Kathleen P. Plotzke, and Mark J. Utell (pp. 43-56).
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PBPK modeling of irbesartan: incorporation of hepatic uptake

Biopharmaceutics & Drug Disposition, 2015
AbstractPhysiological based pharmacokinetic (PBPK) modeling is now commonly used in drug development to integrate human or animal physiological data in order to predict pharmacokinetic profiles. The aim of this work was to construct and refine a PBPK model of irbesartan taking into account its active uptake via OATP1B1/B3 in order to predict more ...
Helene, Chapy, Sylvie, Klieber, Priscilla, Brun, Sabine, Gerbal-Chaloin, Xavier, Boulenc, Olivier, Nicolas   +5 more
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A PBPK model for midazolam in four avian species

Journal of Veterinary Pharmacology and Therapeutics, 2009
A physiologically based pharmacokinetic (PBPK) model was developed for midazolam in the chicken and extended to three other species. Physiological parameters included organ weights obtained from 10 birds of each species and blood flows obtained from the literature. Partition coefficients for midazolam in tissues vs.
K A, Cortright, S E, Wetzlich, A L, Craigmill   +2 more
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Assessing interindividual variability by Bayesian-PBPK modeling

Drug Discovery Today: Disease Models, 2016
The description of interindividual variability and the ADME-related sources of such variability (ADME: absorption, distribution, metabolization, excretion) is an essential element in clinical drug development to identify potentially relevant subgroups of non-responders or high-risk patients.
Markus Krauss, Andreas Schuppert
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