Results 191 to 200 of about 8,529 (239)

Rapid PBPK modeling with the httk model

, 2018
A Course on Physiologically Based Pharmacokinetic (PBPK) Modeling Given at ScitoVation Nov ...
John Wambaugh (230167)
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Variability of physiologically based pharmacokinetic (PBPK) model parameters and their effects on PBPK model predictions in a risk assessment for perchloroethylene (PCE)

Toxicology Letters, 1993
When used in the risk assessment process, the output from physiologically based pharmacokinetic (PBPK) models has usually been considered as an exact estimate of dose, ignoring uncertainties in the parameter values used in the model and their impact on model predictions. We have collected experimental data on the variability of key parameters in a PBPK
J M Gearhart, Harvey J Clewell, J W Fisher   +2 more
exaly   +3 more sources

PHYSIOLOGICAL “CONSTANTS” FOR PBPK MODELS FOR PREGNANCY

Journal of Toxicology and Environmental Health, 1997
Physiologically based pharmacokinetic (PBPK) models for pregnancy are inherently more complex than conventional PBPK models due to the growth of the maternal and embryo/fetal tissues. Physiological parameters such as compartmental volumes or flow rates are relatively constant at any particular time during gestation when an acute experiment might be ...
J F, Young, W S, Branham, D M, Sheehan, M E, Baker, W D, Wosilait, R H, Luecke   +5 more
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The Implications of Using a Physiologically Based Pharmacokinetic (PBPK) Model for Pesticide Risk Assessment [PDF]

Environmental Health Perspectives, 2010
Background: A physiologically based pharmacokinetic (PBPK) model would make it possible to simulate the dynamics of chemical absorption, distribution, metabolism, and elimination (ADME) from different routes of exposures and, in theory, could be used to ...
Chensheng Lu
exaly   +2 more sources

QSARs for PBPK modelling of environmental contaminants

SAR and QSAR in Environmental Research, 2011
Physiologically-based pharmacokinetic (PBPK) models are increasingly finding use in risk assessment applications of data-rich compounds. However, it is a challenge to determine the chemical-specific parameters for these models, particularly in time- and resource-limiting situations.
T, Peyret, K, Krishnan
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Postnatal Growth Considerations for PBPK Modeling

Journal of Toxicology and Environmental Health, Part A, 2007
A physiologically based pharmacokinetic (PBPK) model and Windows-based program (called PostNatal) was developed that focuses on postnatal growth, from birth through adulthood, using appropriate growth curves for each species and gender. Postnatal growth algorithms relating organs/tissues weights with total body weight for male and female humans, dogs ...
Richard H, Luecke, Bruce A, Pearce, Walter D, Wosilait, William, Slikker, John F, Young   +4 more
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PBPK and Toxicokinetic Modeling

2022
Presentation to OpenTox 2022 on Sept. 16, 2022 Science Inventory, CCTE products: https://cfpub.epa.gov/si/si_public_search_results.cfm?advSearch=true&showCriteria=2&keyword=CCTE&TIMSType=&TIMSSubTypeID=&epaNumber=&ombCat=Any&dateBeginPublishedPresented=07/01/2017&dateEndPublishedPresented=&dateBeginUpdated=& ...
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Monoclonal antibody disposition: a simplified PBPK model and its implications for the derivation and interpretation of classical compartment models

Journal of Pharmacokinetics and Pharmacodynamics, 2014
The structure, interpretation and parameterization of classical compartment models as well as physiologically-based pharmacokinetic (PBPK) models for monoclonal antibody (mAb) disposition are very diverse, with no apparent consensus.
Wilhelm Huisinga, Huisinga Wilhelm
exaly   +2 more sources

Analysis of PBPK Models for Risk Characterization

Annals of the New York Academy of Sciences, 1999
Abstract: Adoption of a Bayesian framework for risk characterization permits the seamless integration of different kinds of information available in order to choose and parameterize risk models. It also becomes easy to disentangle uncertainty from variability, through hierarchical statistical modeling.
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