Results 171 to 180 of about 13,844,580 (194)

Evaluation of Adefovir PBPK Model to Assess Biomarker-Informed OAT1 Drug-Drug Interaction and Effect of Chronic Kidney Disease. [PDF]

CPT Pharmacometrics Syst Pharmacol
Tan SPF, Wu H, Rostami-Hodjegan A, Scotcher D, Galetin A.   +4 more
europepmc   +1 more source

stormTB: a web-based simulator of a murine minimal-PBPK model for anti-tuberculosis treatments. [PDF]

Front Pharmacol
Visintainer R, Fochesato A, Boaretti D, Giampiccolo S, Watson S, Levi M, Reali F, Marchetti L.   +7 more
europepmc   +1 more source

A Parent-Metabolite Middle-Out PBPK Model for Genistein and Its Glucuronide Metabolite in Rats: Integrating Liver and Enteric Metabolism with Hepatobiliary and Enteroluminal Transport to Assess Glucuronide Recycling. [PDF]

Pharmaceutics
Ramisetty BS, Singh R, Hu M, Wang MZ.
europepmc   +1 more source

Development of a Physiologically Based Pharmacokinetic (PBPK) Model for F-53B in Pregnant Mice and Its Extrapolation to Humans. [PDF]

Environ Sci Technol
Zhang J, Li SP, Li QQ, Zhang YT, Dong GH, Canchola A, Zeng X, Chou WC.   +7 more
europepmc   +1 more source

Model-Informed Radiopharmaceutical Therapy Optimization: A Study on the Impact of PBPK Model Parameters on Physical, Biological, and Statistical Measures in ¹⁷⁷Lu-PSMA Therapy. [PDF]

Cancers (Basel)
Abdollahi H, Fele-Paranj A, Rahmim A.
europepmc   +1 more source

Can 3D Printed Tablets Be Bioequivalent and How to Test It: A PBPK Model Based Virtual Bioequivalence Study for Ropinirole Modified Release Tablets. [PDF]

Pharmaceutics
Shuklinova O, Wyszogrodzka-Gaweł G, Baran E, Lisowski B, Wiśniowska B, Dorożyński P, Kulinowski P, Polak S.   +7 more
europepmc   +1 more source

PBPK model reporting template for chemical risk assessment applications

Regulatory Toxicology and Pharmacology, 2020
Physiologically-based pharmacokinetic (PBPK) modeling analysis does not stand on its own for regulatory purposes but is a robust tool to support drug/chemical safety assessment.
Michelle Embry, Alicia Paini, John F. Wambaugh   +2 more
exaly   +2 more sources

The Implications of Using a Physiologically Based Pharmacokinetic (PBPK) Model for Pesticide Risk Assessment [PDF]

Environmental Health Perspectives, 2010
Background: A physiologically based pharmacokinetic (PBPK) model would make it possible to simulate the dynamics of chemical absorption, distribution, metabolism, and elimination (ADME) from different routes of exposures and, in theory, could be used to ...
Chensheng Lu
exaly   +2 more sources