Dynamically simulating the interaction of midazolam and the CYP3A4 inhibitor itraconazole using individual coupled whole-body physiologically-based pharmacokinetic (WB-PBPK) models [PDF]
, 2007 Michaela Vossen +5 more
core +1 more source
Physiologically Based Pharmacokinetic (PBPK) Model-Informed Dosing Guidelines for Pediatric Clinical Care: A Pragmatic Approach for a Special Population. [PDF]
Paediatr Drugs, 2023 Freriksen JJM +4 more
europepmc +1 more source
Advancing Pharmacoequity in Low‐ and Middle‐Income Countries via Model Informed Drug Development
Clinical and Translational Science, Volume 19, Issue 5, May 2026.ABSTRACT Across low‐ and middle‐income countries (LMICs) inequities in access to safe, effective medicines persist due to limited regulatory capacity, inadequate financing, and insufficient local data. Regulatory authorities are engaging with model‐informed drug development (MIDD), but uneven technical readiness and resource gaps limit uptake ...
Henry Enzama +5 more
wiley +1 more source
A PBPK model describing the pharmacokinetics of γ-HBCD exposure in mice. [PDF]
Toxicol Appl Pharmacol, 2021 Emond C, DeVito MJ, Birnbaum LS.
europepmc +1 more source
Predicting Pharmacokinetic Variability and Drug Interaction Risk Using Omics‐Based Biomarkers
Clinical and Translational Science, Volume 19, Issue 5, May 2026.ABSTRACT Interindividual variability in drug pharmacokinetics and susceptibility to drug–drug interactions remain major barriers in precision dosing, particularly for narrow therapeutic index drugs. While genetic factors contribute, much variability arises from dynamic influences such as physiology, disease, age, diet, microbiome, and concomitant ...
Bhagwat Prasad
wiley +1 more source
Refinement and calibration of a human PBPK model for the plasticiser, Di-(2-propylheptyl) phthalate (DPHP) using in silico, in vitro and human biomonitoring data. [PDF]
Front Pharmacol, 2023 McNally K, Loizou G.
europepmc +1 more source
In Silico Dosimetry Study of Tc99m-Tetrofosmin in Children Using a Novel PBPK Model in Humans Built from SPECT Imaging Data. [PDF]
Pharm Res, 2023 Kaikousidis C, Dokoumetzidis A.
europepmc +1 more source
This deliverable will report the final development of the human PBPK models developed within ...
openaire +1 more source
Development, testing, parameterisation, and calibration of a human PBPK model for the plasticiser, di-(2-ethylhexyl) terephthalate (DEHTP) using in silico, in vitro and human biomonitoring data. [PDF]
Front Pharmacol, 2023 McNally K, Sams C, Hogg A, Loizou G.
europepmc +1 more source
Using available in vitro metabolite identification and time course kinetics for β-chloroprene and its metabolite, (1-chloroethenyl) oxirane, to include reactive oxidative metabolites and glutathione depletion in a PBPK model for β-chloroprene. [PDF]
Front Pharmacol, 2023 Campbell JL +4 more
europepmc +1 more source