Results 151 to 160 of about 13,844,580 (194)

Moxifloxacin-Mediated Downregulation of Intestinal P-Glycoprotein Alters the Pharmacokinetics of Dabigatran Etexilate: Mechanistic Insights in Rats and PBPK Model-Informed Dose Optimization. [PDF]

Pharmaceutics
Qu Y, Yang Z, Ma W, Xiao P, Gu Y, Pan J, Zhang X, Zhao C, Yu Y.   +8 more
europepmc   +1 more source

A PBPK model recapitulates early kinetics of anti-PEG antibody-mediated clearance of PEG-liposomes. [PDF]

J Control Release, 2022
Talkington AM, McSweeney MD, Wessler T, Rath MK, Li Z, Zhang T, Yuan H, Frank JE, Forest MG, Cao Y, Lai SK.   +10 more
europepmc   +1 more source

Development of an adult whole-body PBPK model of irinotecan and its metabolites for predicting UGT1A1/CYP3A-mediated drug-drug interactions. [PDF]

Front Pharmacol
Chen B, Li L, Xu W, Xu H, Zhu X, He Q, Zhu X, Chi-Lui Ho P, Xiang X, Ji P.   +9 more
europepmc   +1 more source

Predicting Regional Respiratory Tissue and Systemic Concentrations of Orally Inhaled Drugs through a Novel PBPK Model. [PDF]

Drug Metab Dispos, 2022
Ladumor MK, Unadkat JD.
europepmc   +1 more source

Coproporphyrin I PBPK model in the open systems pharmacology suite enables precise prediction of OATP 1B- mediated drug interactions through calibrated <i>In vivo</i> inhibition constants. [PDF]

Front Pharmacol
Kanacher T, Pellowe M, Kovar C, Eriksson J, Wu J, Busse D, Gómez-Mantilla JD, Stopfer P, Ince I, Huang F.   +9 more
europepmc   +1 more source

Optimization of Bottom-Up PBPK Model Development in SIMCYP via Retrospective Analysis of Clinical Human PK Data. [PDF]

Clin Transl Sci
Schulz Pauly JA, Leblanc AF, Chowdhury EA, Qian Y, Rezaei L, Lee CM, Badawi M, Kikuchi R.   +7 more
europepmc   +1 more source

Using available in vitro metabolite identification and time course kinetics for β-chloroprene and its metabolite, (1-chloroethenyl) oxirane, to include reactive oxidative metabolites and glutathione depletion in a PBPK model for β-chloroprene. [PDF]

Front Pharmacol, 2023
Campbell JL, Clewell HJ, Van Landingham C, Gentry PR, Andersen ME.   +4 more
europepmc   +1 more source

Application of Physiologically-Based Pharmacokinetic (PBPK) Model in Drug Development and in Dietary Phytochemicals. [PDF]

Curr Pharmacol Rep
Chou P, Shannar A, Pan Y, Dave PD, Xu J, Kong AT.   +5 more
europepmc   +1 more source

Development and Performance Verification of the PBPK Model for Antazoline and Its Metabolite and Its Utilization for Pharmacological Hypotheses Formulating. [PDF]

Pharmaceuticals (Basel), 2022
Wiśniowska B, Giebułtowicz J, Piotrowski R, Kułakowski P, Polak S.   +4 more
europepmc   +1 more source

Comparative Analysis of Isavuconazole DDIs With Other Azole Antifungal Drugs and PBPK Model-Informed Dosing Recommendations for Anticancer Drugs. [PDF]

CPT Pharmacometrics Syst Pharmacol
Goosen TC, Wu X, Lin J, Cheruvu N, Raber SR, de Figueiredo MLN, Varma MVS.   +6 more
europepmc   +1 more source