CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 6, June 2026.ABSTRACT Burn injuries cause physiological changes that alter enoxaparin pharmacokinetics, often leading to inadequate exposure and suboptimal venous thromboembolism (VTE) prophylaxis. Current weight‐based dosing and anti‐Xa monitoring provide limited guidance for dose optimization across burn severities.
Sabiha Rahman Mim +2 more
wiley +1 more source
Physiologically Based Pharmacokinetic (PBPK) Model-Informed Dosing Guidelines for Pediatric Clinical Care: A Pragmatic Approach for a Special Population. [PDF]
Paediatr Drugs, 2023 Freriksen JJM +4 more
europepmc +1 more source
A PBPK model describing the pharmacokinetics of γ-HBCD exposure in mice. [PDF]
Toxicol Appl Pharmacol, 2021 Emond C, DeVito MJ, Birnbaum LS.
europepmc +1 more source
CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 6, June 2026.ABSTRACT The topoisomerase I inhibitor payload (DXd) released from the human epidermal growth factor receptor 2‐targeted antibody–drug conjugate (ADC) trastuzumab deruxtecan (T‐DXd) is eliminated by hepatic uptake via OATP1B1/3, metabolism by CYP3A, biliary excretion via P‐glycoprotein and breast cancer resistance protein, and urinary excretion.
Akiko Watanabe +6 more
wiley +1 more source
Refinement and calibration of a human PBPK model for the plasticiser, Di-(2-propylheptyl) phthalate (DPHP) using in silico, in vitro and human biomonitoring data. [PDF]
Front Pharmacol, 2023 McNally K, Loizou G.
europepmc +1 more source
Clinical and Translational Science, Volume 19, Issue 6, June 2026.ABSTRACT Quantitative medicine supports modern drug development and regulatory decision‐making by integrating non‐clinical and clinical data to inform dose selection, trial optimization, and extrapolation across populations and benefit–risk assessment.
Essam Kerwash +3 more
wiley +1 more source
In Silico Dosimetry Study of Tc99m-Tetrofosmin in Children Using a Novel PBPK Model in Humans Built from SPECT Imaging Data. [PDF]
Pharm Res, 2023 Kaikousidis C, Dokoumetzidis A.
europepmc +1 more source
Update of the risk assessment on dioxins and dioxin‐like PCBs in feed and food
EFSA Journal, Volume 24, Issue 6, June 2026.Abstract The European Commission asked EFSA to update its 2018 risk assessment on polychlorinated dibenzo‐p‐dioxins and dibenzofurans (PCDD/Fs) and dioxin‐like polychlorinated biphenyls (DL‐PCBs) in feed and food, based on the 2022 WHO Toxic Equivalency Factors (WHO2022‐TEFs).
EFSA Panel on Contaminants in the Food Chain (CONTAM Panel) +27 more
wiley +1 more source
Development, testing, parameterisation, and calibration of a human PBPK model for the plasticiser, di-(2-ethylhexyl) terephthalate (DEHTP) using in silico, in vitro and human biomonitoring data. [PDF]
Front Pharmacol, 2023 McNally K, Sams C, Hogg A, Loizou G.
europepmc +1 more source