Cluster Gauss-Newton method analyses of PBPK model parameter combinations of coproporphyrin-I based on OATP1B-mediated rifampicin interaction studies. [PDF]
CPT Pharmacometrics Syst Pharmacol, 2022 Yoshikado T +6 more
europepmc +1 more source
Development of a Pregnancy-Specific Physiologically Based Pharmacokinetics (PBPK) Model for Aspirin. [PDF]
CPT Pharmacometrics Syst PharmacolCollins-Smith A +5 more
europepmc +1 more source
Using available in vitro metabolite identification and time course kinetics for β-chloroprene and its metabolite, (1-chloroethenyl) oxirane, to include reactive oxidative metabolites and glutathione depletion in a PBPK model for β-chloroprene. [PDF]
Front Pharmacol, 2023 Campbell JL +4 more
europepmc +1 more source
This deliverable will report the final development of the human PBPK models developed within ...
openaire +1 more source
Development of an adult whole-body PBPK model of irinotecan and its metabolites for predicting UGT1A1/CYP3A-mediated drug-drug interactions. [PDF]
Front PharmacolChen B +9 more
europepmc +1 more source
A PBPK model recapitulates early kinetics of anti-PEG antibody-mediated clearance of PEG-liposomes. [PDF]
J Control Release, 2022 Talkington AM +10 more
europepmc +1 more source
Optimization of Bottom-Up PBPK Model Development in SIMCYP via Retrospective Analysis of Clinical Human PK Data. [PDF]
Clin Transl SciSchulz Pauly JA +7 more
europepmc +1 more source
Application of Physiologically-Based Pharmacokinetic (PBPK) Model in Drug Development and in Dietary Phytochemicals. [PDF]
Curr Pharmacol RepChou P +5 more
europepmc +1 more source
Predicting Regional Respiratory Tissue and Systemic Concentrations of Orally Inhaled Drugs through a Novel PBPK Model. [PDF]
Drug Metab Dispos, 2022 Ladumor MK, Unadkat JD.
europepmc +1 more source
Comparative Analysis of Isavuconazole DDIs With Other Azole Antifungal Drugs and PBPK Model-Informed Dosing Recommendations for Anticancer Drugs. [PDF]
CPT Pharmacometrics Syst PharmacolGoosen TC +6 more
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