Results 51 to 60 of about 12,486 (248)
Mathematics, 2022 Here we describe a toolkit for presenting physiologically based pharmacokinetic (PBPK) models in a modular graphical view in the BioUML platform.
Elena Kutumova +4 more
doaj +1 more source
SISO APP Searches in Lattices with Tanner Graphs
, 2011 An efficient, low-complexity, soft-output detector for general lattices is presented, based on their Tanner graph (TG) representations. Closest-point searches in lattices can be performed as non-binary belief propagation on associated TGs; soft ...
Ionescu, Dumitru Mihai, Zhu, Haidong
core +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aims To translate a PBPK model developed for the direct oral anticoagulant, dabigatran etexilate, the prodrug of dabigatran, based on data obtained from healthy men to healthy non‐pregnant, pregnant and post‐partum women. To evaluate safety and efficacy of dabigatran etexilate in post‐partum women using simulations and design a future clinical study to
Kayode Ogungbenro +3 more
wiley +1 more source
Cutting Edge PBPK Models and Analyses: Providing the Basis for Future Modeling Efforts and Bridges to Emerging Toxicology Paradigms [PDF]
, 2012 Physiologically based Pharmacokinetic (PBPK) models are used for predictions of internal or target dose from environmental and pharmacologic chemical exposures.
Jane C. Caldwell +2 more
core +1 more source
Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics
British Journal of Clinical Pharmacology, EarlyView.Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay +5 more
wiley +1 more source
PLoS ONE, 2023 The exposure of a dendritic nanoparticle and its conjugated active pharmaceutical ingredient (API) was determined in mouse, rat and dog, with the aim of investigating interspecies differences facilitating clinical translation.
Christina Vasalou +4 more
doaj +1 more source
HD Physiology Project-Japanese efforts to promote multilevel integrative systems biology and physiome research. [PDF]
, 2017 The HD Physiology Project is a Japanese research consortium that aimed to develop methods and a computational platform in which physiological and pathological information can be described in high-level definitions across multiple scales of time and size.
for HD physiology project investigators +3 more
core
Modélisation physiologique des interactions métaboliques [PDF]
, 2009 National audienceModeling metabolic interactions between chemicals can be a task of formidable complexity. Here I present a new approach and new tools to facilitate that development.
Bois, Frédéric Y.
core +3 more sources
British Journal of Clinical Pharmacology, EarlyView.Aims Amoxicillin, a widely used β‐lactam antibiotic, requires improved pharmacokinetic characterization during breastfeeding. This study used a population pharmacokinetic (PopPK) approach to model amoxicillin concentrations in breast milk, identify variability sources and estimate infant exposure, applying worst‐case scenarios.
Sarah Baklouti +9 more
wiley +1 more source
Development of a physiologically based kinetic model for 99m-Technetium-labelled carbon nanoparticles inhaled by humans [PDF]
, 2009 International audienceParticulate air pollution is associated with respiratory and cardiovascular morbidity and mortality. Recent studies investigated whether and to which extent inhaled ultrafine particles are able to translocate into the bloodstream in
Bois, Frédéric Y. +4 more
core +3 more sources