Results 61 to 70 of about 12,660 (249)

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source

Tingkat Parasitasi Parasitoid Telur Pbpk pada Pertanaman Padi dengan Beberapa Ketinggian Tempat Berbeda [PDF]

, 2015
Rice is the staple food of Indonesia\u27s population. Various problems occur in an effort to increase production and productivity. One problem is the attack of yellow rice stem borer (PBPK) which may result in yield losses up to 90%.
M. Rehan Saleem (748807), Munshoor Ahmed (748806), Saqib Zia (748808), Shamsul Qamar (748809)   +3 more
core   +7 more sources

PBPK Modeling: Empowering Drug Development and Precision Dosing in China

CPT: Pharmacometrics & Systems Pharmacology
Physiologically based pharmacokinetic (PBPK) modeling, a cornerstone of model‐informed drug development and model‐informed precision dosing, simulates drug disposition in the human body by integrating physiological, biochemical, and physicochemical ...
Dongsheng Yang, Jian Li, Wen Yao Mak, Aole Zheng, Xiao Zhu, Qingfeng He, Yuzhu Wang, Xiaoqiang Xiang   +7 more
doaj   +1 more source

A Mechanistic, Model-Based Approach to Safety Assessment in Clinical Development [PDF]

, 2012
Peer ...
Becker, T, Brosch, M, Görlitz, L, Hampe, J, Kuepfer, L, Laffert, B, Lippert, J, Meyer, M, Neuvonen, PJ, Niemi, M, Schafmayer, C, Schreiber, S, Siegmund, H.-U, von Kampen, O   +13 more
core   +1 more source

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Population Physiologically‐Based Pharmacokinetic Modeling to Determine Ontogeny: A Quantitative Clinical Pharmacology Example in Pediatric Rare Disease

CPT: Pharmacometrics & Systems Pharmacology
Pediatric physiologically‐based pharmacokinetic (PBPK) modelling plays an increasing role in selecting doses in children and addressing clinical pharmacology questions.
Yumi Cleary, Bhagwat Prasad, Kayode Ogungbenro, Michael Gertz, Aleksandra Galetin   +4 more
doaj   +1 more source

HD Physiology Project-Japanese efforts to promote multilevel integrative systems biology and physiome research. [PDF]

, 2017
The HD Physiology Project is a Japanese research consortium that aimed to develop methods and a computational platform in which physiological and pathological information can be described in high-level definitions across multiple scales of time and size.
for HD physiology project investigators, Furutani, Kazuharu, Kurachi, Yoshihisa, Tsumoto, Kunichika   +3 more
core  

Construction of PBPK model of quercetin and predicting pharmacokinetic behavior in humans

Zhongguo shipin weisheng zazhi
ObjectiveTo use physiologically based pharmacokinetic （PBPK） model to predict the tissue distribution of quercetin in human， and analyze its distribution and metabolic transformation process in different physiological compartments， so as to supplement ...
XU Nu, SHI Miaoying, JIA Xudong, YANG Xingfen, ZHANG Lei, WU Yongning   +5 more
doaj   +1 more source

Applied Concepts in PBPK Modeling: How to Extend an Open Systems Pharmacology Model to the Special Population of Pregnant Women

CPT: Pharmacometrics & Systems Pharmacology, 2018
This tutorial presents the workflow of adapting an adult physiologically based pharmacokinetic (PBPK) model to the pregnant populations using the Open Systems Pharmacology (OSP) software suite (www.open-systems-pharmacology.org).
André Dallmann, Juri Solodenko, Ibrahim Ince, Thomas Eissing   +3 more
doaj   +1 more source

Complex Mixtures: Array PBPK Modeling of Jet Fuel Components

Toxics, 2023
An array physiologically-based pharmacokinetic (PBPK) model represents a streamlined method to simultaneously quantify dosimetry of multiple compounds. To predict internal dosimetry of jet fuel components simultaneously, an array PBPK model was coded to simulate inhalation exposures to one or more selected compounds: toluene, ethylbenzene, xylenes, n ...
Teresa R. Sterner, Tammie R. Covington, David R. Mattie   +2 more
openaire   +3 more sources