Results 51 to 60 of about 12,660 (249)

ZeroPM piece 12 PBPK modelling

ZeroPM Pieces, 2022
ZeroPM piece 12 about PBPK modelling. The presentation can be viewed as a film on the ZeroPM youtube channel.
openaire   +1 more source

Autonomous AI‐Driven Design for Skin Product Formulations

Advanced Intelligent Discovery, EarlyView.
This review presents a comprehensive closed‐loop framework for autonomous skin product formulation design. By integrating artificial intelligence‐driven experiment selection with automated multi‐tiered assays, the approach shifts development from trial‐and‐error to intelligent optimisation.
Yu Zhang, Yongrui Xiao, Chunlin Chen, Dimitrios Tsaoulidis, Kai Yang, Tao Chen   +5 more
wiley   +1 more source

Mechanistic Coupling of a Novel in silico Cotyledon Perfusion Model and a Physiologically Based Pharmacokinetic Model to Predict Fetal Acetaminophen Pharmacokinetics at Delivery

Frontiers in Pediatrics, 2021
Little is known about placental drug transfer and fetal pharmacokinetics despite increasing drug use in pregnant women. While physiologically based pharmacokinetic (PBPK) models can help in some cases to shed light on this knowledge gap, adequate ...
Paola Mian, Bridget Nolan, Bridget Nolan, John N. van den Anker, John N. van den Anker, Kristel van Calsteren, Kristel van Calsteren, Karel Allegaert, Karel Allegaert, Karel Allegaert, Nisha Lakhi, Nisha Lakhi, André Dallmann   +12 more
doaj   +1 more source

Sex as a biological variable in nonclinical studies: Bridging scientific rigor, animal welfare, and regulatory expectations

Animal Models and Experimental Medicine, EarlyView.
Sex as a biological variable (SABV) is a critical determinant of pharmacokinetics, pharmacodynamics, and toxicity in nonclinical studies. This review highlights how inappropriate neglect of sex differences compromises animal welfare, scientific reproducibility, and regulatory compliance.
Kenta Onuma, Masaki Watanabe, Nobuya Sasaki   +2 more
wiley   +1 more source

Quantitative Analysis of Tozadenant Using Liquid Chromatography-Mass Spectrometric Method in Rat Plasma and Its Human Pharmacokinetics Prediction Using Physiologically Based Pharmacokinetic Modeling

Molecules, 2019
Tozadenant is one of the selective adenosine A2a receptor antagonists with a potential to be a new Parkinson’s disease (PD) therapeutic drug. In this study, a liquid chromatography-mass spectrometry based bioanalytical method was qualified and ...
Byeong ill Lee, Min-Ho Park, Seok-Ho Shin, Jin-Ju Byeon, Yuri Park, Nahye Kim, Jangmi Choi, Young G. Shin   +7 more
doaj   +1 more source

Physiologically-based pharmacokinetic and toxicokinetic models for estimating human exposure to five toxic elements through oral ingestion [PDF]

, 2017
Biological monitoring and physiologically-based pharmacokinetic (PBPK) modelling are useful complementary tools in quantifying human exposure to elements in the environment.
Alloway, Amzal, ATSDR, Bailey, Bechet, Berglund, Brown, Buchet, Choudhury, Chris Collins, Clewell, Coelho, De Flora, El-Masri, Environment Agency, Eric Dede, Evans, Finley, Fleming, Fransson, Horak, Hsieh, Hughes, Hwang, John W. Cherrie, Ju, Kelly, Kerger, Kirman, Kjellstrom, Krishnan, Leggett, Liao, Lyons, MacMillan, Mann, Marcus J. Tindall, McNeely, McNeely, Morisawa, Nielsen, Nordberg, O’Flaherty, O’Flaherty, O’Flaherty, Paustenbach, Prakash, R Core Team, Rabinowitz, Ruiz, Sasso, Schmitt, Steve Hankin, Sunderman, Walther, Wen, White, Yu, Yu   +58 more
core   +1 more source

Research progress in animal models of dry eye disease: Types, mechanisms, and application prospects

Animal Models and Experimental Medicine, EarlyView.
Pivotal multifactorial animal models for translational dry eye disease research. Abstract Dry eye disease (DED) is a prevalent and complex multifactorial ocular surface disorder, leading to significant visual discomfort and diminished quality of life.
Jinshen Liu, Jiaqi Chen, Zhonghui Li, Jiamin Zhou, Hui Zhang, Yujia Yu, Feng Cheng, Jie Bao, Chunhan Feng, Xiangqu Yu, Zhao Xia, Rao Ding, Xiang Li   +12 more
wiley   +1 more source

Human Food Safety Implications of Variation in Food Animal Drug Metabolism [PDF]

, 2016
Citation: Lin, Z., Vahl, C. I., & Riviere, J. E. (2016). Human Food Safety Implications of Variation in Food Animal Drug Metabolism. Scientific Reports, 6.
Lin, Zhoumeng, Riviere, Jim E., Vahl, Christopher I.   +2 more
core   +1 more source

Modular Representation of Physiologically Based Pharmacokinetic Models: Nanoparticle Delivery to Solid Tumors in Mice as an Example

Mathematics, 2022
Here we describe a toolkit for presenting physiologically based pharmacokinetic (PBPK) models in a modular graphical view in the BioUML platform.
Elena Kutumova, Ilya Akberdin, Ilya Kiselev, Ruslan Sharipov, Fedor Kolpakov   +4 more
doaj   +1 more source

Validation of computational approaches for antiretroviral dose optimization [PDF]

, 2016
Strategies for reducing antiretroviral doses and drug costs can support global access, and numerous options are being investigated. Efavirenz pharmacokinetic simulation data generated with a bottom-up physiologically based model were successfully ...
Dickinson, L, Owen, A, Siccardi, M
core   +1 more source