Results 171 to 180 of about 17,065,304 (244)

Targeting m6A Modifications Regulating Ferroptosis Offers Novel Therapy in Diseases

Cell Proliferation, Volume 59, Issue 9, September 2026.
m6A RNA modification regulates ferroptosis by balancing iron metabolism, lipid peroxidation, and antioxidant defenses. Dysregulated m6A signaling disrupts pro‐ and anti‐ferroptotic factors, leading to excess ROS, Fe3+ accumulation, and lipid peroxidation–driven cell death. Targeting m6A‐mediated ferroptotic regulation represents a promising therapeutic
Lida Du, Joshua S. Fleishman, Shuang Wu, Yuan Zhou, Clara X. Wang, Haitong Wang, Yumin Wang, Hongquan Wang   +7 more
wiley   +1 more source

Luteolin prevents cadmium-induced PC12 cell death by suppressing the Akt/mTOR signaling pathway. [PDF]

Medicine (Baltimore)
Zhang X, Xu W, Li H, Ruan D, Chen S, Chu N, Zhen Q, Wang Y.   +7 more
europepmc   +1 more source

Chronic Methamphetamine Administration Increases Mitochondrial Density and Impairs Mitochondrial Function in the Substantia Nigra Pars Compacta

Journal of Neurochemistry, Volume 170, Issue 9, September 2026.
Chronic administration of methamphetamine, an addictive and neurotoxic psychostimulant, results in degeneration of dopamine neurons in the substantia nigra pars compacta of male mice. The current study demonstrates that chronic administration of methamphetamine also results in an accumulation of mitochondria with impaired function in the substantia ...
Aishwarya Bhowmik, Jennifer A. Wilking, Duha Alshareef, Colin Campbell, Steven M. Graves   +4 more
wiley   +1 more source

Synthesis and Antioxidant Effects of Edaravone-Loaded MPEG-2000-DSPE Micelles in Rotenone-Induced PC12 Cell Model of Parkinson's Disease. [PDF]

Nanomaterials (Basel)
Luo X, Luo L, Lai R, Li Y, Zhou H, Li X.
europepmc   +1 more source

A Quarter Century of EHD Protein Research: From Endosomal Recycling to Ciliopathies

Traffic, Volume 27, Issue 3, September 2026.
Human EHD protein subcellular localization. ABSTRACT Eps15 homology domain‐containing proteins comprise a conserved family of membrane‐remodeling ATPases that regulate endocytic trafficking, membrane fission, receptor recycling, primary ciliogenesis and membrane dynamics across eukaryotes. Since the initial identification of EHD1 and its Caenorhabditis
Devin Frisby, Gunjan Misri, Naava Naslavsky, Steve Caplan   +3 more
wiley   +1 more source

Substrate topography affects PC12 cell differentiation through mechanotransduction mechanisms. [PDF]

Mechanobiol Med
Papadimitriou L, Karagiannaki A, Stratakis E, Ranella A.   +3 more
europepmc   +1 more source

N-Terminal Proteolysis of Full-Length Mutant Huntingtin in an Inducible PC12 Cell Model of Huntington’s Disease

Cell Cycle, 2007
T. Ratovitski, Masayuki Nakamura, J. D'Ambola, E. Chighladze, Yideng Liang, Wenfei Wang, R. Graham, M. Hayden, D. Borchelt, R. Hirschhorn, C. Ross   +10 more
semanticscholar   +1 more source

The role of heat shock proteins in lipopolysaccharide-induced PC12 cell death

, 2003
\ue8\ub1 \ue6 \ue6 \ue8\ua6 We investigated the role of heat shock proteins (HSPs), particularly HSP60, HSP70 or HSP90 in E. coli lipopolysaccharide (LPS)-induced naïve pheochrommocytoma cell (PC12) death.
Chang, Te-Yu
core  

Investigation into Antioxidant Mechanism of Lycium barbarum Extract in Carbendazim-Induced PC12 Cell Injury Model through Transcriptomics and Metabolomics Analyses. [PDF]

Foods
Liu P, Chen J, Wen X, Shi X, Yin X, Yu J, Qian Y, Gou C, Xu Y.   +8 more
europepmc   +1 more source

Mitogen-activated protein kinase activation is insufficient for growth factor receptor-mediated PC12 cell differentiation

Molecular and Cellular Biology, 1995
R. Vaillancourt, Lynn E. Heasley, Jeffrey Zamarripa, B. Storey, Mindaugas Valius, Andrius Kazlauskas, G. L. Johnson   +6 more
semanticscholar   +1 more source