Results 51 to 60 of about 17,065,304 (244)

Polydopamine Nanoparticle‐Mediated Precise Near‐Infrared Optical Stimulation for Cognitive Enhancement

open access: yesAdvanced Science, EarlyView.
Polydopamine nanoparticles enable a precise, non‐genetic, and transcranial neuromodulation strategy via near‐infrared photothermal stimulation. By activating TRPV1 channels, this approach specifically enhances hippocampal gamma oscillations, thereby rescuing spatial memory deficits in models of perioperative neurocognitive disorder.
Yan‐Bo Zhou   +10 more
wiley   +1 more source

Ginsenoside Rb1 promotes PC12 cell cycle kinetics through an adenylate cyclase-dependent protein kinase A pathway. [PDF]

open access: yes, 2012
[[abstract]]Ginsenoside Rb1 (G-Rb1), a constituent of ginseng, bears various beneficial effects on neuroendocrine cells. Previous studies have indicated that G-Rb1 can enhance glutamate release in undifferentiated and differentiated PC12 cells via the ...
Shin-Da Lee;Ming-Jae Lo
core  

Ultrasound‐Activated Piezoelectric Neuroimmune Hydrogel Orchestrates Neurogenesis‐Macrophage Crosstalk in Diabetic Wound Healing

open access: yesAdvanced Science, EarlyView.
In this work, we design an ultrasound‐activated piezoelectric hydrogel platform (AOEF@AP5+US) that reprograms neurogenesis‐macrophage crosstalk as an integrated strategy to overcome the intertwined barriers of chronic inflammation, peripheral neuropathy, and impaired regeneration in diabetic wounds.
Kai Wang   +13 more
wiley   +1 more source

The effect of bupivacaine on the proliferation and metastasis of tumor cells in an in vitro model of perineural invasion of cholangiocarcinoma and its mechanism [PDF]

open access: yes精准医学杂志
Objective To investigate the effect of bupivacaine on the proliferation and metastasis of tumor cells in an in vitro model of perineural invasion of cholangiocarcinoma and its mechanism.
CHEN Menshou, FENG Yujie
doaj   +1 more source

Dental pulp stem cells stimulate neuronal differentiation of PC12 cells

open access: yesNeural Regeneration Research, 2021
Dental pulp stem cells (DPSCs) secrete neurotrophic factors which may play an important therapeutic role in neural development, maintenance and repair.
Nessma Sultan   +4 more
doaj   +1 more source

Cell viability of pheochromocytoma 12 (PC12) and differentiated PC12 cells following 24 hours ketamine treatment.

open access: yes, 2013
A) Phase contrast image of undifferentiated PC12 cells. B) Phase contrast image of PC12 cells differentiated with nerve growth factor (NGF) (50 ng/ml) for 6 days. C) Dosage effects of ketamine on cell viability in undifferentiated PC12 cells.
Wan-Hua Amy Yu (310506)   +4 more
core   +1 more source

Rocket‐Inspired Sequentially Targeted Nanotherapeutics for Mitochondrial Regulation and Inflammatory Reprogramming in Ischemic Stroke

open access: yesAdvanced Science, EarlyView.
A novel neutrophil‐hitchhiking, rocket‐inspired nanoplatform is developed to cross the blood‐brain barrier for sequential, spatiotemporal drug delivery. By responsive surface transformation in the ischemic penumbra, it precisely targets mitochondria to suppress Drp1‐mediated fission.
He Bai   +17 more
wiley   +1 more source

Chlorogenic acid protects PC12 cells against corticosterone-induced neurotoxicity related to inhibition of autophagy and apoptosis

open access: yesBMC Pharmacology and Toxicology, 2019
Background There are evidences that chlorogenic acid (CGA) has antidepressant effects, however the underlying molecular mechanism has not been well understood. The aim of the study was to explore the neuroprotective effect of CGA on corticosterone (CORT)-
Xiaowen Shi   +6 more
doaj   +1 more source

The effect of Descurainia sophia oil on methamphetamine-induced cell cytotoxicity and cell death in PC12 [PDF]

open access: yes, 2019
Methamphetamine causes cytotoxicity and apoptosis in different cell lines. It seems that Descurainia sophia oil, as an East Asian folk herbal drug, can suppress the methamphetamine-induced cell death.
Moradi, R.   +13 more
core   +1 more source

Regulating Cells Fate and Function to Facilitate Bone Regeneration via Designing Programmable Bio‐Interactive Materials

open access: yesAdvanced Science, EarlyView.
This article aims to elucidate the biological mechanisms of bone repair and the evolution of material design, highlighting key cellular and molecular processes. It further proposes strategies and prospects for programmable bio‐interactive materials, which enable precisely guided bone tissue regeneration by dynamically regulating cell behavior and the ...
Qingrui Fan   +6 more
wiley   +1 more source

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