Results 61 to 70 of about 17,065,304 (244)

Chrysin, which targets PLAU, protects PC12 cells from OGD/R-stimulated damage through repressing the NF-κB signaling pathway

Regenerative Therapy, 2022
Cerebral ischemia reperfusion injury (CIRI) is a great challenge for the patients with brain ischemia, but its pathophysiological mechanism has not been clearly explored.
Ning Li, Ying Liu, Ju-Rong Li, Wen-Xue Zhang   +3 more
doaj   +1 more source

A Microenvironment‐Adaptive Scaffold Rejuvenates Peripheral Nerve Regeneration During Aging Via Dual Modulation of Ferroptotic Stimuli in Schwann Cells

Advanced Science, EarlyView.
(i) Aging impairs peripheral nerve regeneration via its dual ferroptosis‐mediated pathologies in senescent schwann cells. (ii) The composite nerve conduit is a symbiosis niche integrating microenvironment‐responsive nanoparticles (Ga‐PTAs) and maxillofacial‐derived mesenchymal stem cells (Mmscs).
Ning Zhan, Lixin Tian, Lianjie Peng, Jingyu Zhang, Lining Lin, Xiaoting Zhang, Yaxian Luo, Zhichao Liu, Xinhua Yao, Mouyuan Sun, Yong He, Mengfei Yu, Huiming Wang   +12 more
wiley   +1 more source

Transplantation of Polymer Encapsulated Pc12 Cells: Use of Chitosan as an Immobilization Matrix

Cell Transplantation, 1993
Polymer capsules were fabricated to encapsulate PC12 cells within a semipermeable and immunoprotective barrier. The inclusion of precipitated chitosan as an immobilization matrix within the polymer capsules increased the survival and physiological ...
Dwaine F. Emerich, Beata R. Frydel, Tom R. Flanagan, Meg Palmatier, Shelley R. Winn, Lisa Christenson   +5 more
doaj   +1 more source

Synergistic Neuroprotective Effect of Endogenously-Produced Hydroxytyrosol and Synaptic Vesicle Proteins on Pheochromocytoma Cell Line against Salsolinol

Molecules, 2020
Oxidative stress triggers a lethal cascade, leading to Parkinson’s disease by causing degeneration of dopaminergic neurons. In this study, eight antioxidants were screened for their neuroprotective effect on PC12 cells (pheochromocytoma cell line) under ...
Robina Manzoor, Aamir Rasool, Maqbool Ahmed, Ullah Kaleem, Lucienne Nneoma Duru, Hong Ma, Yulin Deng   +6 more
doaj   +1 more source

NGF regulates the PC12 cell cycle machinery through specific inhibition of the Cdk kinases and induction of cyclin D1

Journal of Neuroscience, 1995
We have examined the effects of NGF on components of the PC12 cell cycle machinery. We show that NGF represses over 6–8 d the levels of specific cdk kinase proteins and the G2-M phase specific cyclin B1 and the S phase marker PCNA as well as the level of
Guo-Zai Yan, E. Ziff
semanticscholar   +1 more source

Efeitos biológicos e moleculares de compostos orgânicos sintéticos de selênio sobre o sistema nervoso central e neurotoxicidade do manganês [PDF]

, 2009
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciencias Biológicas. Programa de Pós-Graduação em Neurociências.No presente estudo foi analisado o potencial antioxidante e protetor do composto orgânico sintético de selênio difenil ...
Posser, Thaís
core  

PC12 cell lines assays.

, 2012
(A) Permeability to water and glycerol of wild type PC12 cells and PC12 transfected with either AQP1 or AQP3.
Antonella Ciancetta (164206), Teresa F. Moura (164231), Angela Casini (164243), Alessandro Marrone (152381), Nazzareno Re (152384), Ana Galán Cobo (164214), Miriam Echevarría (164223), Graça Soveral (164250), Ana Paula Martins (164194)   +8 more
core   +1 more source

ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

Advanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang, Zitong Huang, Yu Tao, Yunmei Zhang, Yufang Sun, Dongsheng Jiang, Weiwei Lu, Fuhai Ji, Gang Chen, Min Xu, Yuan Zhang, Jin Tao   +11 more
wiley   +1 more source

Germacrone protects against oxygen-glucose deprivation/reperfusion injury by inhibiting autophagy processes in PC12 cells

BMC Complementary Medicine and Therapies, 2020
Background Germacrone is an anti-inflammatory ingredient in the Chinese medicine zedoary turmeric. The purpose of this study was to explore the protective mechanism of germacrone against PC12 cells injury caused by oxygen-glucose deprivation/reperfusion (
Jianxing Zhang, Li Yuan, Sujie Wang, Jiang Liu, Huiqin Bi, Guojuan Chen, Jingjing Li, Lili Chen   +7 more
doaj   +1 more source

Sequential Regulation of Neurovascular Bone Regeneration in Large Bone Defects Using Black Phosphorus‐Europium Nanosheet Integrated TPMS Biomimetic Scaffold with Photo‐Controlled Ion Release

Advanced Science, EarlyView.
TPBE scaffolds, in conjunction with mild photothermal effects, effectively activate the PI3K/Akt signaling cascade, thereby promoting early neuronal differentiation and neurite growth. Short‐term (12 W) in vivo implantation studies revealed no significant pathological damage to major organs, providing preliminary evidence of the material's excellent ...
Bingqian Wang, Yuping Zhang, Xiaoning Su, Ning Liu, Hui Zeng, Bo Yang, Yang Xue, Fang Guo, Changkui Liu   +8 more
wiley   +1 more source