Results 201 to 210 of about 4,447,834 (239)
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Extracellular toxicity of 6-hydroxydopamine on PC12 cells
Neuroscience Letters, 20006-hydroxydopamine (6-OHDA) is usually thought to cross cell membrane through dopamine uptake transporters, to inhibit mitochondrial respiration and to generate intracellular reactive oxygen species. In this study, we show that the anti-oxidants catalase, glutathione and N-acetyl-cysteine are able to reverse the toxic effects of 6-OHDA. These two latter
Blum, David +4 more
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Induction of Apoptosis by Melamine in Differentiated PC12 Cells
Cellular and Molecular Neurobiology, 2010Melamine (2, 4, 6-triamino-1, 3, 5-triazine) was found in milk powder as an additive to raise the measured protein content in 2008 and thereby resulted in the outbreak of renal failure in infants in China. Previous studies focused on the renal toxicity in dogs and in cats.
Yang-guang, Han +3 more
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SIRPĪ± negatively regulates differentiation of PC12 cell
Molecular Brain Research, 2005Signal regulatory protein alpha (SIRPalpha) is an Ig superfamily protein whose cytoplasmic region contains immunoreceptor tyrosine-based inhibitory motif (ITIM), which when tyrosine phosphorylated binds the SH2-domain containing phosphatase 2 (SHP-2). Both SIRPalpha and SHP-2 are highly expressed in brain.
Bin, Kang +8 more
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The CSPĪ±/G protein complex in PC12 cells
Biochemical and Biophysical Research Communications, 2007Cysteine string proteinalpha (CSPalpha) is a regulated vesicle protein and molecular chaperone that has been found to be critical for continuous synaptic transmission and is implicated in the defense against neurodegeneration. Previous work has revealed links between CSPalpha and heterotrimeric GTP binding protein (G protein) signal transduction ...
Liping, Bai +2 more
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Melatonin suppression of PC12 cell growth and death
Brain Research, 1997Melatonin has previously been reported to influence cell differentiation and growth in a number of cell culture systems in vitro. In this paper, we describe the effects of high pharmacological and low physiological concentrations of melatonin on cell growth in rat pheochromocytoma cells (PC12 cells).
J A, Roth, R, Rabin, K, Agnello
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Kinetics of regulation of neurotensin content in PC12 cells
Life Sciences, 1983The mechanism by which nerve growth factor (NGF) and dexamethasone synergistically increase the content of neurotensin (NT) in PC12 cells can be partially separated into NGF and dexamethasone-mediated components by study of cultures pre-treated with either agent.
A S, Tischler +3 more
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Effects of scoparone on dopamine release in PC12 cells
Fitoterapia, 2010The effects of scoparone on dopamine release in PC12 cells were investigated. Scoparone at 50-200 microM increased dopamine release into the culture medium. However, the released levels of dopamine by scoparone were not altered in the absence of extracellular Ca(2+) and by adenylyl cyclase inhibitor MDL-12,330A.
Yoo Jung, Yang +5 more
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The toxicity of 6-hydroxydopamine on PC12 and P19 cells
Molecular Brain Research, 1999Considerable evidence implicates the involvement of mitochondrial dysfunction in neurodegenerative diseases. 6OHDA is a mitochondrial complex I inhibitor which is frequently used to model Parkinson's disease-like cell loss. We investigated the cell death pathways triggered by 6OHDA in PC12 and P19 cells with a view to shedding light on the molecular ...
A, Woodgate +3 more
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The Effect of Phenylalanine on DOPA Synthesis in PC12 Cells
Neurochemical Research, 1998DOPA synthesis from phenylalanine was studied in PC12 cells incubated with m-hydroxybenzylhydrazine, to inhibit aromatic L-amino acid decarboxylase. DOPA synthesis rose with increasing concentrations of either phenylalanine or tyrosine; maximal rates (approximately 55 pmol/min/mg protein for tyrosine; approximately 40 pmol/min/mg protein for ...
F R, DePietro, J D, Fernstrom
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Neurodegenerative effects of azithromycin in differentiated PC12 cells
European Journal of Pharmacology, 2017Azithromycin is a widely used macrolide antibiotic with sustained and high tissue penetration and intracellular accumulation. While short-term exposure to low-dose azithromycin is usually well tolerated, prolonged treatment can lead to unwanted neurological effects like paresthesia and hearing loss.
Vicki, Waetzig +7 more
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