Loss of PCAF in proximal tubular cells exacerbates renal fibrosis by promoting partial epithelial-to-mesenchymal transition [PDF]
Experimental and Molecular MedicineRenal fibrosis is a consequence of chronic kidney disease, which is estimated to affect 10–14% of the global population. The molecular mechanisms in the pathogenesis of renal fibrosis are still unclear, and there is a lack of effective therapies. Here we
Hyunsik Kim +8 more
doaj +3 more sources
PCAF-mediated acetylation regulates RAD51 dynamic localization on chromatin during HR repair [PDF]
EMBO ReportsPCAF (p300-associated factor), a major histone acetyltransferase, is involved in many metabolic and pathogenic diseases. Here, we reveal a novel function of PCAF in homologous recombination repair (HR).
Jiajia Hou +11 more
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Posttranslational regulation of the GCN5 and PCAF acetyltransferases
PLOS Genetics, 2022 General control nonderepressible 5 protein (Gcn5) and its homologs, including p300/CBP-associated factor (PCAF), are lysine acetyltransferases that modify both histone and non-histone proteins using acetyl coenzyme A as a donor substrate. While decades of studies have uncovered a vast network of cellular processes impacted by these acetyltransferases ...
Onyekachi E. Ononye, Michael Downey
semanticscholar +7 more sources
PCAF Accelerates Vascular Senescence via the Hippo Signaling Pathway [PDF]
Oxidative Medicine and Cellular Longevity, 2022 P300/CBP‐Associated Factor (PCAF), one of the histone acetyltransferases (HATs), is known to be involved in cell growth and/or differentiation. PCAF is reported to be involved in atherosclerotic plaques and neointimal formation. However, its role in cellular senescence remains undefined.
Chaohua Kong +11 more
semanticscholar +4 more sources
Cooperation of p300 and PCAF in the control of microRNA 200c/141 transcription and epithelial characteristics. [PDF]
PLoS ONE, 2012 Epithelial to mesenchymal transition (EMT) not only occurs during embryonic development and in response to injury, but is an important element in cancer progression. EMT and its reverse process, mesenchymal to epithelial transition (MET) is controlled by
Yoshiaki Mizuguchi +6 more
doaj +3 more sources
Transcriptional synergy between Tat and PCAF is dependent on the binding of acetylated Tat to the PCAF bromodomain [PDF]
The EMBO Journal, 2002 The human immunodeficiency virus (HIV) Tat protein plays an essential role in promoting efficient transcriptional elongation of viral transcripts. We report that the transcriptional co-activator PCAF and Tat interact and synergize to activate the HIV promoter.
Alexander Dorr
openalex +4 more sources
PCAF Acetylates β-Catenin and Improves Its Stability [PDF]
Molecular Biology of the Cell, 2008 β-Catenin plays an important role in development and tumorigenesis. However, the effect of a key acetyltransferase p300/CBP-associated factor (PCAF) on β-catenin signaling is largely unknown. In this study, we found PCAF could increase the β-catenin transcriptional activity, induce its nuclear translocation, and up-regulate its protein level by ...
Xinjian Ge +4 more
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PCAF Improves Glucose Homeostasis by Suppressing the Gluconeogenic Activity of PGC-1α [PDF]
Cell Reports, 2014 PGC-1α plays a central role in hepatic gluconeogenesis and has been implicated in the onset of type 2 diabetes. Acetylation is an important posttranslational modification for regulating the transcriptional activity of PGC-1α. Here, we show that PCAF is a
Cheng Sun +9 more
doaj +2 more sources
GCN5 inhibits XBP-1S-mediated transcription by antagonizing PCAF action [PDF]
Oncotarget, 2014 Cellular unfolded protein response (UPR) is induced when endoplasmic reticulum (ER) is under stress. XBP-1S, the active isoform of X-box binding protein 1 (XBP-1), is a key regulator of UPR. Previously, we showed that a histone acetyltransferase (HAT), p300/CBP-associated factor (PCAF), binds to XBP-1S and functions as an activator of XBP-1S.
Qiao Jing Lew +9 more
openalex +4 more sources
PCAF-mediated acetylation of Lin28B increases let-7 biogenesis in lung adenocarcinoma H1299 cells [PDF]
BMC Cancer, 2018 Background Lin28B and its paralog Lin28A are small RNA binding proteins that have similar inhibitory effects, although they target separate steps in the maturation of let-7 miRNAs in mammalian cells.
Ting-ting Qu +7 more
doaj +2 more sources