Results 101 to 110 of about 16,705 (253)

Targeting the lactylation of ENO1 alleviates endothelial dysfunction in sepsis

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
Lactylation of ENO1 reduced the binding of TRIM21 mRNA to ENO1, thereby preventing mRNA degradation. Elevated TRIM21 subsequently binds to VE‐Cadherin, promoting its ubiquitination. Targeting the lactylation of ENO1 with a specific inhibitory peptide alleviated endothelial dysfunction.
Xueru Xie, Tingyan Liu, Caiyan Zhang, Ye Cheng, Yajing Gao, Wenfeng Xiao, Haiyan Guo, Yutong Zhou, Yawei Yu, Kexin Wang, Yinghong Lin, Lisheng Xiao, Yingying Zhang, Weiguo Yang, Gangfeng Yan, Guoping Lu, Yufeng Zhou   +16 more
wiley   +1 more source

Stochastic calculus over symmetric Markov processes without time reversal

, 2012
We refine stochastic calculus for symmetric Markov processes without using time reverse operators. Under some conditions on the jump functions of locally square integrable martingale additive functionals, we extend Nakao's divergence-like continuous ...
Kuwae, Kazuhiro
core   +1 more source

Adenovirus E1B 55-Kilodalton Oncoprotein Inhibits p53 Acetylation by PCAF [PDF]

Molecular and Cellular Biology, 2000
The adenovirus E1B 55-kDa protein binds to cellular tumor suppressor p53 and inactivates its transcriptional transactivation function. p53 transactivation activity is dependent upon its ability to bind to specific DNA sequences near the promoters of its target genes.
Y, Liu, A L, Colosimo, X J, Yang, D, Liao   +3 more
openaire   +2 more sources

Non‐canonical nitric oxide signalling and DNA methylation: Inflammation induced epigenetic alterations and potential drug targets

British Journal of Pharmacology, Volume 183, Issue 1, Page 24-39, January 2026.
Abstract DNA methylation controls DNA accessibility to transcription factors and other regulatory proteins, thereby affecting gene expression and hence cellular identity and function. As epigenetic modifications control the transcriptome, epigenetic dysfunction is strongly associated with pathological conditions and ageing.
Christopher H. Switzer
wiley   +1 more source

SIRT7 activates p53 by enhancing PCAF-mediated MDM2 degradation to arrest the cell cycle

Oncogene, 2020
Sirtuin 7 (SIRT7), an NAD + -dependent deacetylase, plays vital roles in energy sensing, but the underlying mechanisms of action remain less clear. Here, we report that SIRT7 is required for p53-dependent cell-cycle arrest during glucose deprivation.
Ya-Fei Lu, Xiao-Peng Xu, Xiaopeng Lu, Qian Zhu, Ge Liu, Yantao Bao, He Wen, Yinglu Li, W. Gu, Wei-Guo Zhu   +9 more
semanticscholar   +1 more source

CBP/p300 is a cell type-specific modulator of CLOCK/BMAL1-mediated transcription

Molecular Brain, 2009
Background Previous studies have demonstrated tissue-specific regulation of the rhythm of circadian transcription, suggesting that transcription factor complex CLOCK/BMAL1, essential for maintaining circadian rhythm, regulates transcription in a tissue ...
Hosoda Hiroshi, kato Kenichi, Asano Hidenori, Ito Motonori, Kato Haruno, Iwamoto Taku, Suzuki Akinobu, Masushige Shoichi, Kida Satoshi   +8 more
doaj   +1 more source

Targeting Mast Cell Activation and MIF‐Mediated Remodelling Enhances Chemotherapy Response in Pancreatic Cancer

Advanced Science, Volume 12, Issue 48, December 29, 2025.
Neoadjuvant gemcitabine plus nab‐paclitaxel (AG) reprograms pancreatic ductal adenocarcinoma by shifting malignant cells toward a classical phenotype and remodeling the tumor microenvironment. Despite enhancing cytotoxic NKT cells, AG activates tumor‐associated mast cells (TAMCs) and inflammatory CAFs through MIF signaling.
Libo Wang, Guangcong Shen, Guanpeng Xie, Zekun Li, Xiaoqing Ma, Mengyu Li, Ziyun Liu, Yadi Wang, Zongjing Lv, Qingxiao Fang, Huihui Sun, Ningning Zhao, Chao Yang, Tianxing Zhou, Yongjie Xie, Jun Yu, Jihui Hao   +16 more
wiley   +1 more source

Núcleo de Apoio à Saúde da Família: promoção da saúde, atividade física e doenças crônicas no Brasil - inquérito nacional PMAQ 2013

Epidemiologia e Serviços de Saúde, 2019
Resumo Objetivo: descrever o relato de ações de promoção da saúde dirigidas a portadores de doenças crônicas não transmissíveis, o apoio do profissional de educação física (PEF) e a realização da ação de promoção de práticas corporais e atividade ...
Thamires Lorenzet Cunha Seus, Denise Silva da Silveira, Elaine Tomasi, Elaine Thumé, Luiz Augusto Facchini, Fernando Vinholes Siqueira   +5 more
doaj   +2 more sources

On the heat kernel and the Dirichlet form of Liouville Brownian Motion

, 2013
In \cite{GRV}, a Feller process called Liouville Brownian motion on $\R^2$ has been introduced. It can be seen as a Brownian motion evolving in a random geometry given formally by the exponential of a (massive) Gaussian Free Field $e^{\gamma X}$ and is ...
Garban, Christophe, Rhodes, Rémi, Vargas, Vincent   +2 more
core   +2 more sources

Gankyrin‐Protein Interactions in GI Cancers: A Novel Target of New Therapeutics

Chronic Diseases and Translational Medicine, Volume 11, Issue 4, Page 269-278, December 2025.
ABSTRACT Gankyrin (PSMD10) is a 25 kDa oncogenic protein and regulatory subunit of the 26S proteasome, characterized by a sevenfold ankyrin repeat domain. Gankyrin is overexpressed in various malignancies, particularly gastrointestinal (GI) cancers. Gankyrin contributes to tumorigenesis by modulating key signaling pathways and engaging in oncogenic ...
Shuang Li, Yuky Lam, Aaron Muth, Zhe‐Sheng Chen, Shanzhi Wang   +4 more
wiley   +1 more source