Results 111 to 120 of about 16,705 (253)

Liouville Brownian motion

, 2016
We construct a stochastic process, called the Liouville Brownian motion, which is the Brownian motion associated to the metric $e^{\gamma X(z)}\,dz^2 ...
Garban, Christophe, Rhodes, Rémi, Vargas, Vincent   +2 more
core   +1 more source

Reversible acetylation of Lin28 mediated by PCAF and SIRT1

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2014
Lin28 is a small RNA-binding protein that plays an important role in regulating developmental timing, stem cell reprogramming, and oncogenesis. However, the significance of the effect of post-translational modifications on Lin28 activity is not fully understood. In this study, we demonstrated that PCAF directly interacted with and acetylated Lin28.
Wang, Ling-xia, Wang, Jing, Qu, Ting-ting, Zhang, Ye, Shen, Yu-fei   +4 more
openaire   +2 more sources

Crosstalk Between Cancer‐Associated Fibroblasts and Immune Cells: Mechanisms and Therapeutic Implications

MedComm – Oncology, Volume 4, Issue 4, December 2025.
Cancer‐associated fibroblasts (CAFs) are widely engaged in tumor progression in the tumor microenvironment. CAFs interact actively with immunocytes including tumor‐associated macrophages, T cells, neutrophils, and NK cells in a positive‐feedback loop to sculpt tumor immune microenvironment and participate in tumor activities and antitumor therapy ...
Ya Li, Xingpeng Di, Jiawei Chen, Jingwen Wei, Tianyue Li, Kunjie Wang, Banghua Liao, Deyi Luo   +7 more
wiley   +1 more source

Role of Histone Deacetylase and Inhibitors in Cardiovascular Diseases

Cell Proliferation, Volume 58, Issue 12, December 2025.
HDACs play an important role in the occurrence and development of cardiovascular diseases, such as myocardial hypertrophy, hypertension, and atherosclerosis. HDAC inhibitors have broad prospects for the treatment of CVD, and different HDAC subtypes can act through different mechanisms.
Li‐Ying Zhang, Yue‐Yue Wang, Ri Wen, Tie‐Ning Zhang, Ni Yang   +4 more
wiley   +1 more source

Bridging the SME reporting gap: A new model for predicting Scope 1 and 2 emissions

Journal of Industrial Ecology, Volume 29, Issue 6, Page 2197-2213, December 2025.
Abstract We present a novel statistical model for predicting Scope 1 and 2 emissions for small and medium‐sized enterprises (SMEs). Trained on financial transaction data from over 100,000 UK SMEs, the model targets a business segment excluded from formal emissions reporting and often under‐engaged in sustainability efforts.
Alec Phillpotts, Anne Owen, Jonathan Norman, Anna Trendl, John Gathergood, Norbert Jobst, David Leake   +6 more
wiley   +1 more source

Crystal structure of GCN5 PCAF N-terminal domain reveals atypical ubiquitin ligase structure

Journal of Biological Chemistry, 2020
General control nonderepressible 5 (GCN5, also known as Kat2a) and p300/CBP-associated factor (PCAF, also known as Kat2b) are two homologous acetyltransferases.
S. Fukai, Ryota Hibi, T. Naganuma, M. Sakai, S. Saijo, N. Shimizu, M. Matsumoto, Toshiyuki Shimizu   +7 more
semanticscholar   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, Volume 599, Issue 21, Page 3012-3028, November 2025.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Percepções de profissionais de Educação Física atuantes na Atenção Primária à Saúde sobre a aproximação das Práticas Corporais e Atividades Físicas com princípios da Promoção da Saúde [PDF]

Revista Brasileira de Ciências do Esporte
RESUMO Este estudo explorou as percepções de Profissionais de Educação Física atuantes na Atenção Primária à Saúde sobre a aproximação entre as Práticas Corporais e Atividades Físicas (PCAF) e os princípios da Política Nacional de Promoção da Saúde ...
Victor Felipe de Assis, Francisco Timbó de Paiva Neto, Mathias Roberto Loch, Cassiano Ricardo Rech   +3 more
doaj   +1 more source

Enzalutamide‐Resistant STEAP4+ MyoCAF Secrete Phosphatidylcholine to Foster Progression by Activating Stemness in Hormone‐Sensitive Prostate Cancer

Advanced Science, Volume 12, Issue 44, November 27, 2025.
Expanding enzalutamide (ENZ) use in hormone‐sensitive prostate cancer (HSPC) faces resistance. Single‐cell profiling identifies therapy‐resistant STEAP4+ myofibroblastic cancer‐associated fibroblast (SETAP4+ myoCAF). These myoCAFs drive resistance via TFE3‐mediated autophagy and PCYT1A‐led phosphatidylcholine overproduction, creating a phospholipid ...
Wenhao Wang, Jing Zhao, Tiewen Li, Guangjian Fan, Jianong Zhang, Chenghao Zheng, Zhiwen Xie, Yu Zhang, Chengling Feng, Tianyu Cao, Jianyin Li, Guomin Ju, Di Cui, Shujie Xia, Bangmin Han   +14 more
wiley   +1 more source

Cancer‐Associated Fibroblasts: Origin, Classification, Tumorigenicity, and Targeting for Cancer Therapy

MedComm, Volume 6, Issue 11, November 2025.
This review explores the multifaceted roles of cancer‐associated fibroblasts (CAFs) in tumor biology. It examines their diverse origins, dynamic activation via signaling pathways, and spatial–temporal heterogeneity, proposing an updated classification of eight distinct CAF subtypes. The review highlights CAFs' contributions to tumor growth, metastasis,
Chang Fan, Wenlong Zhu, Yuan Chen, Wanwan Zhu, Jin Ding   +4 more
wiley   +1 more source