PCAF acts as a gastric cancer suppressor through a novel PCAF-p16-CDK4 axis.
American journal of cancer researchGastric cancer (GC) is a leading cause of cancer-related death worldwide and the pathogenesis of GC remains largely unknown. Here, we demonstrate a novel mechanism by which P300/CBP associating factor (PCAF) acts as a tumor suppressor in GC cells. We showed that both PCAF mRNA and protein were downregulated in GC cells, and that this downregulation ...
Hong-Jun, Fei +6 more
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Regulation of PCAF Activity by Spermidine
, 2011 Histones and polyamines are important determinants of chromatin structure. Histones are the core of nucleosome particles and their modification by acetylation of N-terminal tails is involved in chromatin structural changes and transcriptional modulation.
BURGIO, Giosalba +3 more
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PCAF, SIRT1 and the regulation of substrate acetylation
, 2021 Levels of lysine acetylation (KAc) in cells are regulated by epigenetic enzymes with opposing roles; histone acetyl transferases (HATs) and histone deacetylases (HDACs). The HAT p300 CBP associating factor (PCAF) and the sirtuin HDAC SIRT1 have protein substrates in common, including histone 3 (H3) at lysine residues 9 and 14 (H3K9 and H3K14) and non ...
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Role of p300 and PCAF in regulating cyclooxygenase-2 promoter activation by inflammatory mediators [PDF]
, 2003 Wuguo Deng, Ying Zhu, Kenneth K. Wu
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Histone acetyltransferase PCAF regulates inflammatory molecules in the development of renal injury [PDF]
, 2014 Jin Huang +5 more
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Revista Brasileira de Atividade Física e SaúdeA Sociedade Brasileira de Atividade Física e Saúde (SBAFS) exerce papel importante no desenvolvimento e na disseminação do conhecimento científico, além de promover a articulação entre pesquisadores, estudantes, gestores e profissionais dos serviços de ...
Atila Alexandre Trapé +11 more
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Pcaf Modulates Polyglutamine Pathology in a <i>Drosophila</i> Model of Huntington’s Disease [PDF]
, 2011 László Bodai +3 more
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A recurrent pathogenic BRCA2 truncating variant reveals a role for BRCA2-PCAF complex in modulating NF-κB-driven transcription [PDF]
Anna Minello +19 more
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Rücktitelbild: Discovery of a PCAF Bromodomain Chemical Probe (Angew. Chem. 3/2017) [PDF]
, 2016 Moses Moustakim +22 more
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Parathyroid Hormone Activation of Matrix Metalloproteinase-13 Transcription Requires the Histone Acetyltransferase Activity of p300 and PCAF and p300-dependent Acetylation of PCAF [PDF]
, 2010 Minnkyong Lee, Nicola C. Partridge
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