Results 11 to 20 of about 16,705 (253)

PCAF promotes R-loop resolution via histone acetylation. [PDF]

Nucleic Acids Res
Abstract R-loops cause genome instability, disrupting normal cellular functions. Histone acetylation, particularly by p300/CBP-associated factor (PCAF), is essential for maintaining genome stability and regulating cellular processes. Understanding how R-loop formation and resolution are regulated is important because dysregulation of ...
Lee SY, Lee SH, Choi NH, Kim JY, Kweon JH, Miller KM, Kim JJ.   +6 more
europepmc   +4 more sources

Activation of AMPK inhibits cervical cancer growth by hyperacetylation of H3K9 through PCAF [PDF]

Cell Communication and Signaling
Background Dysregulation in histone acetylation, a significant epigenetic alteration closely associated with major pathologies including cancer, promotes tumorigenesis, inactivating tumor-suppressor genes and activating oncogenic pathways.
Botao Pan, Can Liu, Jiyan Su, Chenglai Xia   +3 more
doaj   +3 more sources

A recurrent pathogenic BRCA2 truncating variant reveals a role for BRCA2-PCAF complex in modulating NF-κB-driven transcription. [PDF]

Nat Commun
Germline monoallelic truncating mutations in BRCA2, a critical mediator of homologous recombination (HR), predispose individuals to breast and ovarian cancer. While tumorigenesis is usually attributed to biallelic inactivation, emerging evidence suggests
Minello A, Gomez-Escudero J, Sridhara SC, Martin C, Girard E, Cañas JC, Memari Y, Bustos MR, Galarreta A, Boucherit V, Imyanitov E, Bodvarsdottir SK, Baulande S, Vincent-Salomon A, Servant N, Altmeyer M, Sigurdsson S, Stoppa-Lyonnet D, Nik-Zainal S, Carreira A.   +19 more
europepmc   +3 more sources

Targeting macrophage M1 polarization suppression through PCAF inhibition alleviates autoimmune arthritis via synergistic NF-κB and H3K9Ac blockade

Journal of Nanobiotechnology, 2023
Sustained inflammatory invasion leads to joint damage and progressive disability in several autoimmune rheumatic diseases. In recent decades, targeting M1 macrophage polarization has been suggested as a promising therapeutic strategy for autoimmune ...
Jinteng Li, Feng Ye, Xiaojun Xu, Peitao Xu, Peng Wang, Guan Zheng, Guiwen Ye, Wenhui Yu, Zepeng Su, Jiajie Lin, Yunshu Che, Zhidong Liu, Pei Feng, Qian Cao, Dateng Li, Zhongyu Xie, Yanfeng Wu, Huiyong Shen   +17 more
doaj   +2 more sources

Metformin Induces Apoptosis in Human Pancreatic Cancer (PC) Cells Accompanied by Changes in the Levels of Histone Acetyltransferases (Particularly, p300/CBP-Associated Factor (PCAF) Protein Levels)

Pharmaceuticals, 2023
Accumulating evidence (mainly from experimental research) suggests that metformin possesses anticancer properties through the induction of apoptosis and inhibition of the growth and proliferation of cancer cells.
Izabela Szymczak-Pajor, Józef Drzewoski, Ewa Świderska, Justyna Strycharz, Anna Gabryanczyk, Jacek Kasznicki, Marta Bogdańska, Agnieszka Śliwińska   +7 more
doaj   +2 more sources

Modulation of IL-6 Expression by KLF4-Mediated Transactivation and PCAF-Mediated Acetylation in Sublytic C5b-9-Induced Rat Glomerular Mesangial Cells

Frontiers in Immunology, 2022
Interleukin-6 (IL-6) overproduction has been considered to contribute to inflammatory damage of glomerular mesangial cells (GMCs) in human mesangial proliferative glomerulonephritis (MsPGN) and its rat model called Thy-1 nephritis (Thy-1N).
Lu Xia, Yu Liu, Zhiwei Zhang, Yajuan Gong, Tianyi Yu, Dan Zhao, Wen Qiu, Yingwei Wang, Jing Zhang, Jing Zhang, Jing Zhang   +10 more
doaj   +2 more sources

P300/CBP‐associated factor (PCAF)‐mediated acetylation of Fascin at lysine 471 inhibits its actin‐bundling activity and tumor metastasis in esophageal cancer

Cancer Communications, 2021
Background Fascin is crucial for cancer cell filopodium formation and tumor metastasis, and is functionally regulated by post‐translational modifications. However, whether and how Fascin is regulated by acetylation remains unclear.
Yin‐Wei Cheng, Fa‐Min Zeng, Da‐Jia Li, Shao‐Hong Wang, Jian‐Zhong He, Zhen‐Chang Guo, Ping‐Juan Nie, Zhi‐Yong Wu, Wen‐Qi Shi, Bing Wen, Xiu‐E Xu, Lian‐Di Liao, Zhi‐Mao Li, Jian‐Yi Wu, Jun Zhan, Hong‐Quan Zhang, Zhi‐Jie Chang, Kai Zhang, Li‐Yan Xu, En‐Min Li   +19 more
doaj   +2 more sources

RETRACTED ARTICLE: Embelin alleviates weaned piglets intestinal inflammation and barrier dysfunction via PCAF/NF-κB signaling pathway in intestinal epithelial cells

Journal of Animal Science and Biotechnology, 2022
Background Intestinal barrier plays key roles in maintaining intestinal homeostasis. Inflammation damage can severely destroy the intestinal integrity of mammals. This study was conducted to investigate the protective effects of embelin and its molecular
Weilei Yao, Tongxin Wang, Lu Huang, Zhengxi Bao, Shu Wen, Feiruo Huang   +5 more
doaj   +2 more sources

The transcriptional co-activator PCAF regulates cdk2 activity [PDF]

Nucleic Acids Research, 2009
Cyclin dependent kinases (cdks) regulate cell cycle progression and transcription. We report here that the transcriptional co-activator PCAF directly interacts with cdk2. This interaction is mainly produced during S and G(2)/M phases of the cell cycle. As a consequence of this association, PCAF inhibits the activity of cyclin/cdk2 complexes.
Francesca Mateo, Miriam Vidal-Laliena, Núria Canela-Canela, Annalisa Zecchin, Marian A. Martínez‐Balbás, Neus Agell, Mauro Giacca, María Jesús Pujol, Oriol Bachs   +8 more
openalex   +6 more sources

The Lysine Acetyltransferase PCAF Functionally Interacts with Estrogen Receptor Alpha in the Hippocampus of Gonadally Intact Male-But Not Female-Rats to Enhance Short-Term Memory. [PDF]

J Neurosci
Acetylation of histone proteins by histone acetyltransferases (HATs), and the resultant change in gene expression, is a well-established mechanism necessary for long-term memory (LTM) consolidation, which is not required for short-term memory (STM ...
Mitchnick KA, Nicholson K, Wideman C, Jardine K, Jamieson-Williams R, Creighton SD, Lacoursiere A, Milite C, Castellano S, Sbardella G, MacLusky NJ, Choleris E, Winters BD.   +12 more
europepmc   +4 more sources