Results 221 to 230 of about 16,705 (253)

Targeting lysine acetylation readers and writers. [PDF]

Nat Rev Drug Discov
Zhou MM, Cole PA.
europepmc   +1 more source

Modulating PCAF/GCN5 Immune Cell Function through a PROTAC Approach

ACS Chemical Biology, 2018
P300/CBP-associated factor (PCAF) and general control nonderepressible 5 (GCN5) are closely related epigenetic proteins, each containing an acetyltransferase domain and a bromodomain. Consistent with reported roles for these proteins in immune function, we find that PCAF-deficient macrophages exhibit a markedly reduced ability to produce cytokines upon
Zuni I. Bassi, Martin C. Fillmore, Afjal H. Miah, Trevor D. Chapman, Claire Maller, Emma J. Roberts, Lauren C. Davis, Darcy E. Lewis, Nicholas W. Galwey, Kirsty E. Waddington, Valentino Parravicini, Abigail L. Macmillan-Jones, Celine Gongora, Philip G. Humphreys, Ian Churcher, Rab K. Prinjha, David F. Tough   +16 more
openaire   +3 more sources

Some of the next articles are maybe not open access.

Related searches:

Binding mechanism of anacardic acid, carnosol and garcinol with PCAF: A comprehensive study using molecular docking and molecular dynamics simulations and binding free energy analysis

Journal of Cellular Biochemistry, 2023
The p300/CBP associated factor bromodomain (PCAF Brd) is emerged as one of the promising target proteins for different types of cancers. PCAF is one among the histone acetyltransferase enzymes which involved in the regulation of transcriptase process by ...
R. Jaganathan, P. Kumaradhas
semanticscholar   +1 more source

PCAF regulates cardiac muscle function via non-epigenetic regulation of ACTA1 acetylation

Physiology, 2023
Historically, lysine acetylation has been studied in the epigenetic regulation of gene expression, in which it is known to play key roles in cardiac remodeling and dysfunction.
Justine S. Habibian, Levi W. Evans, B. Ferguson   +2 more
semanticscholar   +1 more source

P300/CBP‐associated factor (PCAF) attenuated M1 macrophage inflammatory responses possibly through KLF2 and KLF4

Immunology and Cell Biology, 2021
Macrophages exhibit distinct phenotypes in response to environmental signals. The polarization of M1 macrophages plays an essential role in the inflammatory response.
Xiuling Wang, Haiyan Li, Shanshan Chen, Jinrong He, Wei-qun Chen, Yu Ding, Jin Huang   +6 more
semanticscholar   +1 more source

PCAF acetylates Runx2 and promotes osteoblast differentiation

Journal of Bone and Mineral Metabolism, 2013
Osteoblasts play a crucial role in bone formation. However, the molecular mechanisms involved in osteoblast differentiation remain largely unclear. Runt-related gene 2 (Runx2) is a master transcriptional factor for osteoblast differentiation. Here we reported that p300/CBP-associated factor (PCAF) directly binds to Runx2 and acetylates Runx2, leading ...
Chao-Yang, Wang, Shu-Feng, Yang, Zhong, Wang, Jun-Ming, Tan, Shun-Min, Xing, De-Chun, Chen, Sheng-Ming, Xu, Wen, Yuan   +7 more
openaire   +2 more sources

1,2,4-Triazolo[4,3-c]quinazolines: a bioisosterism-guided approach towards the development of novel PCAF inhibitors with potential anticancer activity

, 2021
Targeting PCAF with small inhibitor molecules has emerged as a potential therapeutic strategy for the treatment of cancer.
Mohamed H. El-Shershaby, Adel H. Ghiaty, A. Bayoumi, Hany E. A. Ahmed, M. El-Zoghbi, Khaled El‐Adl, Hamada S. Abulkhair   +6 more
semanticscholar   +1 more source

Multiple lysine methylation of PCAF by Set9 methyltransferase

Biochemical and Biophysical Research Communications, 2009
The molecular functions of several non-histone proteins are regulated through lysine modification by histone methyltransferases. The p300/CBP-associated factor (PCAF) is an acetyltransferase that has been implicated in many cellular processes. Here, we report that PCAF is a novel substrate of Set9 methyltransferase.
Toshihiro, Masatsugu, Ken, Yamamoto
openaire   +2 more sources

LYSINE ACETYLTRANSFERASES OF BOTH P300/CBP (P300 AND PCAF) AND MYST (TIP60) FAMILIES BUTYRYLATE BETA CATENIN AT LYSINE 345 AND INCREASE ITS TRANSCRIPTIONAL ACTIVITY

Gastroenterology
Intestinal microbial patterns of IBD patients are characterized by decreased abundance of Firmicutes phylum (Walker et al., 2011, PMID: 21219646).
Tatiana Goretsky, Agripina G. Deaciuc, Sarayu Bhogoju, S. Hassan, Neeraj Kapur, Terrence A. Barrett   +5 more
semanticscholar   +1 more source

Abstract 235: Epigenetic Mediator PCAF Moderates Arteriogenesis

Arteriosclerosis, Thrombosis, and Vascular Biology, 2012
Introduction: Collateral artery formation or arteriogenesis is a highly regulated process involving multiple factors and cell types, with a pronounced role for the inflammatory system. In the current study we focus on a transcriptional co-activator P300/CBP-associated factor (PCAF). PCAF, also known as lysine acetyltransferase (
A J Bastiaansen, M M Ewing, A Y Nossent, H A Peters, M R de Vries, A M van Oeveren-Rietdijk, H C de Boer, A J van Zonneveld, P H Quax   +8 more
openaire   +1 more source