Results 231 to 240 of about 16,705 (253)

Acetylation of MKL1 by PCAF regulates pro-inflammatory transcription

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2017
Inflammation is considered a fundamental host defense mechanism and, when aberrantly activated, contributes to a host of human diseases. Previously we have reported that the transcriptional regulator megakaryocytic leukemia 1 (MKL1) plays a role programming cellular inflammatory response by modulating NF-κB activity.
Liming, Yu, Zilong, Li, Mingming, Fang, Yong, Xu   +3 more
openaire   +2 more sources

Expression of histone acetylases p300 and PCAF in pediatric astrocytomas

Child's Nervous System, 2013
The protein 300 (p300) and p300/CBP-binding protein-associated factor (PCAF) are enzymes with histone acetyltransferase (HAT) activity, a function that can become deregulated in different tumors and affect biological responses.Due to the lack of information on the deregulation of these HATs in pediatric tumors, this study evaluated the expression of ...
Pilar, Eguía-Aguilar, Mario, Solís-Paredes, Paulina, Reyes-Cid, Mario, Perezpeña-Diazconti, Fernando Chico-Ponce, de León, Stanislaw, Sadowinski-Pine, Francisco, Arenas-Huertero   +6 more
openaire   +2 more sources

From triazolophthalazines to triazoloquinazolines: A bioisosterism-guided approach toward the identification of novel PCAF inhibitors with potential anticancer activity.

Bioorganic & Medicinal Chemistry, 2021
Mohamed H. El-Shershaby, Adel H. Ghiaty, A. Bayoumi, A. Al-karmalawy, Ebtehal M. Husseiny, M. El-Zoghbi, Hamada S. Abulkhair   +6 more
semanticscholar   +1 more source

PCAF lysine acetyltransferase

AfCS-Nature Molecule Pages, 2008
Cindy Degerny, Nadine Pelletier, Xiang-Jiao Yang   +2 more
openaire   +1 more source

GRIM-19 inhibits proliferation and induces apoptosis in a p53-dependent manner in colorectal cancer cells through the SIRT7/PCAF/MDM2 axis.

Experimental Cell Research, 2021
Ding Wang, Xiaodong Wei, Xuyang Chen, Qian Wang, Jinghua Zhang, D. Kalvakolanu, Baofeng Guo, Ling Zhang   +7 more
semanticscholar   +1 more source

Revealing a new target: Celastrol alleviates pulmonary fibrosis by inhibiting PCAF.

Bioorganic chemistry (Print)
Libo Wang, Fei Lin, Junwei Liu, Zhichao Jia, Mingyang Zhu, Yuan Liu, Yongheng Li, Lin Yang   +7 more
semanticscholar   +1 more source

Identification and insights into the uncommon configuration of novel histone lysine acetyltransferase PCAF and methyltransferase GLP inhibitors from Wikstroemia chamaedaphne by molecular docking, and in vitro assessment.

International Journal of Biological Macromolecules
Xuefen Hou, Tongtong Yu, Choe hyok chol, Jingkai An, Lin Zhang, Meijia Sun, Jasmin Mecinović, Pinyi Gao, Lingzhi Li   +8 more
semanticscholar   +1 more source

PCAF Lysine Acetyltransferase

2016
Linya You, Kezhi Yan, Xiang-Jiao Yang
openaire   +1 more source

PCAF Lysine Acetyltransferase

2012
Linya You, Xiang-Jiao Yang
openaire   +1 more source

The PCAF Histone Acetylase Complex

Biochemical Society Transactions, 1999
openaire   +1 more source