Results 21 to 30 of about 16,705 (253)

Molecular Profile and Clinical Associations of Androgen Receptor Coactivators and Structural Genes in Benign Prostatic Hyperplasia and Metabolic Syndrome [PDF]

Biomedicines
Background/Objectives: Benign prostatic hyperplasia (BPH) is a common condition in older men and represents a major contributor to lower urinary tract symptoms, prostate enlargement, and features of metabolic syndrome (MetS).
Feres Camargo Maluf, Karina Serafim da Silva, Giovana Vilas Boas Caetano, Pedro Henrique Souza Brito, Patricia Candido, Gabriel A. dos Santos, Vanessa Guimarães, Iran Amorim Silva, Alberto Azoubel Antunes, Katia Leite, Miguel Srougi, William Nahas, Ruan Pimenta, Sabrina Reis   +13 more
doaj   +2 more sources

PCAF fine‐tunes hepatic metabolic syndrome, inflammatory disease, and cancer [PDF]

Journal of Cellular and Molecular Medicine, 2018
AbstractThe P300/CBP‐associating factor (PCAF), a histone acetyltransferase, is involved in metabolic and pathogenic diseases, particularly of the liver. The effects of PCAF on fine‐tuning liver diseases are extremely complex and vary according to different pathological conditions.
Tongxin Wang, Weilei Yao, Yafei Shao, Ruilong Zheng, Feiruo Huang   +4 more
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PCAF Involvement in Lamin A/C-HDAC2 Interplay during the Early Phase of Muscle Differentiation

Cells, 2020
Lamin A/C has been implicated in the epigenetic regulation of muscle gene expression through dynamic interaction with chromatin domains and epigenetic enzymes. We previously showed that lamin A/C interacts with histone deacetylase 2 (HDAC2).
Spartaco Santi, Vittoria Cenni, Cristina Capanni, Giovanna Lattanzi, Elisabetta Mattioli   +4 more
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The histone acetylase PCAF is a nuclear receptor coactivator [PDF]

Genes & Development, 1998
Whereas the histone acetylase PCAF has been suggested to be part of a coactivator complex mediating transcriptional activation by the nuclear hormone receptors, the physical and functional interactions between nuclear receptors and PCAF have remained unclear.
Jorge C. G. Blanco, Saverio Minucci, Jianming Lü, Xiang-Jiao Yang, Kristen K. Walker, Hongwu Chen, Ronald M. Evans, Yoshihiro Nakatani, Keiko Ozato   +8 more
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Correction: Targeting macrophage M1 polarization suppression through PCAF inhibition alleviates autoimmune arthritis via synergistic NF-κB and H3K9Ac blockade [PDF]

Journal of Nanobiotechnology, 2023
Jinteng Li, Ye Feng, Xiaojun Xu, Peitao Xu, Peng Wang, Zheng Guan, Tianwei Xie, Wenhui Yu, Zepeng Su, Jiajie Lin, Yunshu Che, Zhidong Liu, Pei Feng, Qian Cao, Dateng Li, Zhongyu Xie, Yanfeng Wu, Huiyong Shen   +17 more
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Distinct but overlapping roles of histone acetylase PCAF and of the closely related PCAF-B/GCN5 in mouse embryogenesis [PDF]

Proceedings of the National Academy of Sciences, 2000
PCAF plays a role in transcriptional activation, cell-cycle arrest, and cell differentiation in cultured cells. PCAF contributes to transcriptional activation by acetylating chromatin and transcription factors through its intrinsic histone acetylase activity.
Teruo Yamauchi, Jun Yamauchi, Takeshi Kuwata, Tomohiko Tamura, Tsuyoshi Yamashita, Nancy Bae, Heiner Westphal, Keiko Ozato, Yoshihiro Nakatani   +8 more
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P300/CBP Associated Factor (PCAF) Deficiency Enhances Diet-Induced Atherosclerosis in ApoE3*Leiden Mice via Systemic Inhibition of Regulatory T Cells

Frontiers in Cardiovascular Medicine, 2021
Background: Inflammatory stimuli induced by NF-kB drive atherosclerotic lesion formation. The epigenetic P300/CBP associated factor (PCAF) post-transcriptionally acetylates FoxP3, which is required for regulatory T-cell (Treg) differentiation and immune ...
Alwin de Jong, Alwin de Jong, Rob C. M. de Jong, Erna A. Peters, Erna A. Peters, Ramon Arens, J. Wouter Jukema, Margreet R. de Vries, Margreet R. de Vries, Paul H. A. Quax, Paul H. A. Quax   +10 more
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Crotonylation of IDH1 alleviates MASLD progression by enhancing the TCA cycle [PDF]

Nature Communications
Metabolic dysfunction–associated steatotic liver disease (MASLD), potentially ameliorated by bariatric-metabolic surgery, remains a global health concern in the absence of approved drugs.
Shanshan Liu, Yu Ji, Luyang Wei, Yiqiao Zhang, Linghang Zeng, Yiyang Min, Danyang Yin, Kun Liu, Chengjian Guan, Shumeng Liu, Huajing Yu, Zhongtao Zhang   +11 more
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Acetyltransferases GCN5 and PCAF Are Required for B Lymphocyte Maturation in Mice

Biomolecules, 2021
B lymphocyte development has two DNA recombination processes: V(D)J recombination of the immunoglobulin (Igh) gene variable region, and class switching of the Igh constant regions from IgM to IgG, IgA, or IgE.
Valentyn Oksenych, Dan Su, Jeremy A. Daniel   +2 more
doaj   +2 more sources

Age-dependent attenuation of spatial memory deficits by the histone acetyltransferase p300/CBP-associated factor (PCAF) in 3xTG Alzheimer's disease mice

Learning & memory (Cold Spring Harbor, N.Y.), 2022
Histone acetylation, catalyzed by histone acetyltransferases, has emerged as a promising therapeutic strategy in Alzheimer's disease (AD). By longitudinally characterizing spatial memory at 3, 6, and 9 mo of age, we show that acute activation and ...
Samantha D. Creighton, Kristen H. Jardine, Alexa Desimone, Megan Zmetana, Sabrina Castellano, Ciro Milite, Gianluca Sbardella, Boyer D. Winters   +7 more
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