Results 31 to 40 of about 16,705 (253)

Complex functions of Gcn5 and Pcaf in development and disease

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2021
A wealth of biochemical and cellular data, accumulated over several years by multiple groups, has provided a great degree of insight into the molecular mechanisms of actions of GCN5 and PCAF in gene activation. Studies of these lysine acetyltransferases (KATs) in vitro, in cultured cells, have revealed general mechanisms for their recruitment by ...
Evangelia, Koutelou, Aimee T, Farria, Sharon Y R, Dent   +2 more
openaire   +4 more sources

PCAF/GCN5-Mediated Acetylation of RPA1 Promotes Nucleotide Excision Repair [PDF]

Cell Reports, 2017
The RPA complex can integrate multiple stress signals into diverse responses by activating distinct DNA repair pathways. However, it remains unclear how RPA1 elects to activate a specific repair pathway during different types of DNA damage.
Meimei Zhao, Rui Geng, Xiang Guo, Ruoshi Yuan, Xiao Zhou, Yanyan Zhong, Yanfei Huo, Mei Zhou, Qinjian Shen, Yinglu Li, Weiguo Zhu, Jiadong Wang   +11 more
doaj   +3 more sources

K(lysine) acetyltransferase 2B (KAT2B; PCAF) [PDF]

Science-Business eXchange, 2013

  +4 more sources

Cold atmospheric plasma enhances SLC7A11-mediated ferroptosis in non-small cell lung cancer by regulating PCAF mediated HOXB9 acetylation

Redox Biology
Chenxing Zhang, Hongyang Liu, X. Li, Nan Xiao, Huanxiang Chen, Haoran Feng, Li Yang, Ying Yang, Ruike Zhang, Xiangzhuan Zhao, Yanmin Du, Lu Bai, Ruonan Ma, Junhu Wan   +13 more
openalex   +2 more sources

Author Correction: Transcriptional synergy between Tat and PCAF is dependent on the binding of acetylated Tat to the PCAF bromodomain. [PDF]

EMBO J
Dorr A, Kiermer V, Pedal A, Rackwitz HR, Henklein P, Schubert U, Zhou MM, Verdin E, Ott M.   +8 more
europepmc   +2 more sources

PCAF Modulates PTEN Activity [PDF]

Journal of Biological Chemistry, 2006
The PTEN protein has a single catalytic domain possessing both lipid phosphoinositol and protein phosphatase activities. The lipid phosphoinositol phosphatase activity is essential for PTEN to block the cell cycle in the G1 phase and thereby to suppress tumor formation and progression (Cantley, L. C., and Neel, B. G. (1999) Proc. Natl. Acad. Sci. U. S.
Koichi, Okumura, Michelle, Mendoza, Robert M, Bachoo, Ronald A, DePinho, Webster K, Cavenee, Frank B, Furnari   +5 more
openaire   +2 more sources

Aspectos a serem considerados na promoção de atividade física por profissionais de saúde

Revista Brasileira de Atividade Física e Saúde, 2022
No Brasil, as práticas corporais e atividade física (PCAF) obtiveram avanços com a implementação de políticas, ações e programas que contribuíram substancialmente com a saúde pública.
Letícia Gonçalves , Andressa Ferreira da Silva, Suellem Zanlorenci, Diego Augusto Santos Silva   +3 more
doaj   +1 more source

Acesso às práticas corporais/atividade física durante o ciclo da vida: relato de idosas aposentadas

Revista Brasileira de Atividade Física e Saúde, 2023
O objetivo foi verificar o acesso às práticas corporais/atividade física (PCAF) ao longo da vida de idosas aposentadas participantes de um grupo de PCAF. Trata-se de um estudo qualitativo com 16 mulheres idosas com idade entre 65 a 75 anos, selecionadas
Yuri Atamanczuk de Oliveira, André Ulian Dall Evedove, Mathias Roberto Loch   +2 more
doaj   +1 more source

Discovery of a PCAF Bromodomain Chemical Probe [PDF]

Angewandte Chemie International Edition, 2016
AbstractThe p300/CBP‐associated factor (PCAF) and related GCN5 bromodomain‐containing lysine acetyl transferases are members of subfamily I of the bromodomain phylogenetic tree. Iterative cycles of rational inhibitor design and biophysical characterization led to the discovery of the triazolopthalazine‐based L‐45 (dubbed L‐Moses) as the first potent ...
Moustakim, Moses; Clark, Peter G. K.; Trulli, Laura; de Arriba, Angel L. Fuentes; Ehebauer, Matthias T.; Chaikuad, Apirat; Murphy, Emma J.; Mendez-Johnson, Jacqui; Daniels, Danette; Hou, Chun-Feng D.; Lin, Yu-Hui; Walker, John R.; Hui, Raymond; Yang, Hongbing; Dorrell, Lucy; Rogers, Catherine M.; Monteiro, Octovia P.; Fedorov, Oleg; Huber, Kilian V. M.; Knapp, Stefan; Heer, Jag; Dixon, Darren J.; Brennan, Paul E.   +23 more
openaire   +6 more sources

The epigenetic factor PCAF regulates vascular inflammation and is essential for intimal hyperplasia development. [PDF]

PLoS ONE, 2017
Genetic P300/CBP-associated factor (PCAF) variation affects restenosis-risk in patients. PCAF has lysine acetyltransferase activity and promotes nuclear factor kappa-beta (NFκB)-mediated inflammation, which drives post-interventional intimal hyperplasia ...
Rob C M de Jong, Mark M Ewing, Margreet R de Vries, Jacco C Karper, Antonius J N M Bastiaansen, Hendrika A B Peters, Fabiana Baghana, Peter J van den Elsen, Céline Gongora, J Wouter Jukema, Paul H A Quax   +10 more
doaj   +1 more source