Results 41 to 50 of about 16,705 (253)
Cell Death and Disease, 2023 Multidrug resistance is a major challenge in treating advanced hepatocellular carcinoma (HCC). Although recent studies have reported that the multidrug resistance phenotype is associated with abnormal DNA methylation in cancer cells, the epigenetic ...
Xiaoen Guo +17 more
semanticscholar +1 more source
The Acetyltransferase p300/CBP-Associated Factor Is a p53 Target Gene in Breast Tumor Cells
Neoplasia: An International Journal for Oncology Research, 2004 p300/CBP-associated factor (PCAF) is a coactivator of the tumor suppressor, p53. PCAF participates in p53's transactivation of target genes through acetylation of both bound p53 and histones within p53 target promoters.
George S. Watts +6 more
doaj +1 more source
Uncovering the IL‐1β‐PCAF‐NNT axis: A new player in ferroptosis and tumor immune evasion
Cancer Communications, 2023 Chronic inflammation is recognized as a crucial hallmark of cancer. Interleukin-1β (IL-1β), one of the proinflammatory cytokines, plays an ambiguous or even contradictory role in cancer development [1].
Qidong Li, Boyi Gan
semanticscholar +1 more source
The chromatin remodeling factor CSB recruits histone acetyltransferase PCAF to rRNA gene promoters in active state for transcription initiation. [PDF]
PLoS ONE, 2013 The promoters of poised rRNA genes (rDNA) are marked by both euchromatic and heterochromatic histone modifications and are associated with two transcription factors, UBF and SL1 that nucleate transcription complex formation.
Meili Shen +9 more
doaj +1 more source
BMC Cancer, 2012 Background Androgen receptor (AR) signalling is critical to the initiation and progression of prostate cancer (PCa). Transcriptional activity of AR involves chromatin recruitment of co-activators, including the p300/CBP-associated factor (PCAF). Distinct
Gong Ai-Yu +7 more
doaj +1 more source
Neoplasia: An International Journal for Oncology Research, 2019 Only 10%–20% of colorectal cancer (CRC) patients observe effective responses to 5-fluorouracil (5-FU) based chemo-treatment. We used real-time PCR array and Western blot analysis to examine the expression alteration of acetyltransferases and deacetylases
Tong Liu +6 more
doaj +1 more source
Cancer Medicine, 2021 Epigenetic regulation is important for cancer tumor metastasis and progression, including lung and liver cancer. However, the mechanism of epigenetic regulation in liver cancer leaves much to be discussed.
Kai‐Ting Chuang +3 more
doaj +1 more source
Inhibition of histone H3K9 acetylation by anacardic acid can correct the over-expression of Gata4 in the hearts of fetal mice exposed to alcohol during pregnancy. [PDF]
PLoS ONE, 2014 BACKGROUND: Cardiovascular malformations can be caused by abnormalities in Gata4 expression during fetal development. In a previous study, we demonstrated that ethanol exposure could lead to histone hyperacetylation and Gata4 over-expression in fetal ...
Chang Peng +7 more
doaj +1 more source
EBioMedicine, 2019 Background: Epigenetic mechanisms have been reported to play key roles in osteoarthritis (OA) development. P300/CBP-associated factor (PCAF) is a member of the histone acetyltransferases, which exhibits a strong relationship with endoplasmic reticulum ...
Deheng Chen +6 more
doaj +1 more source
The p53-HAT connection: PCAF rules? [PDF]
Cell Cycle, 2012 Comment on: Love IM, et al. Cell Cycle 2012; 11:2458-66.
Laptenko, Oleg, Prives, Carol
openaire +1 more source