Current Issues in Molecular Biology, 2023 Abaca (Musa textilis Née) is an economically important fiber crop in the Philippines. Its economic potential, however, is hampered by biotic and abiotic stresses, which are exacerbated by insufficient genomic resources for varietal identification vital ...
Cris Francis C. Barbosa +6 more
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Histone acetyltransferase inhibitor CPTH6 preferentially targets lung cancer stem-like cells [PDF]
, 2016 Cancer stem cells (CSCs) play an important role in tumor initiation, progression, therapeutic failure and tumor relapse. In this study, we evaluated the efficacy of the thiazole derivative 3-methylcyclopentylidene-[4-(4’-chlorophenyl)thiazol-2-yl ...
Buglioni, Simonetta +14 more
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Nucleic Acids Research, 2020 High-mobility group AT-hook 2 (HMGA2) is an architectural transcription factor that plays essential roles in embryonic development and cancer progression. However, the mechanism of HMGA2 regulation remains largely uncharacterized.
Yue Wu +8 more
openalex +2 more sources
The stochastic reflection problem on an infinite dimensional convex set and BV functions in a Gelfand triple [PDF]
, 2012 In this paper, we introduce a definition of BV functions in a Gelfand triple which is an extension of the definition of BV functions in [2] by using Dirichlet form theory.
In A Gelfand Triple +3 more
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PCAF is a coactivator for p73-mediated transactivation [PDF]
Oncogene, 2003 The tumor suppressor p53-related p73 shares significant amino-acid sequence identity with p53. Like p53, p73 recognizes canonical p53 DNA-binding sites and activates p53-responsive target genes and induces apoptosis. Moreover, transcription coactivator p300/CBP binds to and coactivates with both p53 and p73 in stimulating the expression of their target
Lisa Y, Zhao +4 more
openaire +2 more sources
KAT2-mediated PLK4 acetylation contributes to genomic stability by preserving centrosome number
Molecular & Cellular Oncology, 2017 We have recently identified the first human lysine (K) acetyltransferase 2A and 2B (called KAT2A/2B; known also as GCN5/PCAF, respectively)-dependent acetylome and revealed a mechanism by which KAT2A/2B-mediated acetylation of serine/threonine polo-like ...
Marjorie Fournier, László Tora
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Principal component analysis of atrial fibrillation: Inclusion of posterior ECG leads does not improve correlation with left atrial activity [PDF]
, 2015 Background Lead V? is routinely analysed due to its large amplitude AF waveform. V? correlates strongly with right atrial activity but only moderately with left atrial activity. Posterior lead V? correlates strongest with left atrial activity.
Bourke, John P. +6 more
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Pulling a Ligase out of a “HAT”: pCAF Mediates Ubiquitination of the Class II Transactivator
International Journal of Cell Biology, 2017 The Class II Transactivator (CIITA) is essential to the regulation of Major Histocompatibility Class II (MHC II) genes transcription. As the “master regulator” of MHC II transcription, CIITA regulation is imperative and requires various posttranslational
Julie E. Morgan, Susanna F. Greer
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Two chromatin remodeling activities cooperate during activation of hormone responsive promoters. [PDF]
PLoS Genetics, 2009 Steroid hormones regulate gene expression by interaction of their receptors with hormone responsive elements (HREs) and recruitment of kinases, chromatin remodeling complexes, and coregulators to their target promoters. Here we show that in breast cancer
Guillermo Pablo Vicent +8 more
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Is acetylation a metabolic rheostat that regulates skeletal muscle insulin action? [PDF]
, 2015 Skeletal muscle insulin resistance, which increases the risk for developing various metabolic diseases, including type 2 diabetes, is a common metabolic disorder in obesity and aging.
LaBarge, Samuel +2 more
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