Integrative bioinformatics, single-cell and experimental evidence for a BPA-m6A-apoptosis axis in granulosa cell dysfunction in polycystic ovary syndrome. [PDF]
Zhang Y +5 more
europepmc +1 more source
PFOA exposure induces pregnancy loss by promoting glutaminolysis, which further causes ammonia accumulation in macrophages. Cellular ammonia retention results in damage to mitochondria and lysosomes, which leads to cell death eventually. Impaired lysosomes also decrease the secretion of the Cathepsin B (CTSB), and attenuate macrophage infiltration and ...
Yongbo Zhao +6 more
wiley +1 more source
Assessing gonadal hormone contributions to affective psychopathologies across humans and animal models [PDF]
Dohanich, GP, Grissom, EM, Müller, Sven
core +1 more source
This integrated clinical approach optimizes the reproductive cycle in several steps, starting with nutrition (A): restricting carbohydrates and inducing ketosis to reduce inflammation and improve insulin sensitivity, which benefits follicular development.
Tania G. Rojas‐Pérez +7 more
wiley +1 more source
Micronutrients in polycystic ovary syndrome: molecular pathways, deficiencies, and therapeutic potential. [PDF]
Natarajan M, E SH, Nataraj R.
europepmc +1 more source
LZTS2 Negatively Regulates Centrosomal CEP135 Levels and Microtubule Nucleation
ABSTRACT The microtubule cytoskeleton is a fundamental functional component of the cell. In vertebrate proliferating cells, centrosomes are the primary microtubule organizing center (MTOC), and their dysregulation has been linked to genomic instability and cancer.
Catarina Peneda +4 more
wiley +1 more source
Retinal and Choroidal Structural and Microvascular Characteristics in Women With Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Optical Coherence Tomography (OCT) and OCT Angiography (OCTA) Studies. [PDF]
Bousamri A +6 more
europepmc +1 more source
Embryonic Hormetic Priming Modulates Later‐Life Thermal Tolerance
This study investigates how early‐life thermal environments affect later thermal tolerance in the black‐lip pearl oyster, Pinctada margaritifera. Developmental thermal priming had contrasting, family‐specific effects on thermal tolerance, with conserved stress‐response pathways but evidence of priming‐induced regulatory network reorganization.
K. Lugue +7 more
wiley +1 more source

