Results 51 to 60 of about 88,809 (304)

Projecting prevalence by stage of care for prostate cancer and estimating future health service needs: protocol for a modelling study [PDF]

, 2016
Introduction Current strategies for the management of prostate cancer are inadequate in Australia. We will, in this study, estimate current service needs and project the future needs for prostate cancer patients in Australia.
Clements, M. S., McHugh, B., O'Connell, D. L., Patel, M. I., Smith, D. P., Yu, X. Q.   +5 more
core   +1 more source

IGF‐1 Deficiency Serves as an Integrated Biomarker Pathogenic Driver and Predictor in Poor Ovarian Response

Advanced Science, EarlyView.
IGF‐1 deficiency underlies poor ovarian response (POR), as reduced levels in follicular fluid and granulosa cells impair antral follicle formation and compromise reproductive outcomes. Including IGF‐1 as a biomarker significantly enhances the accuracy of models predicting both PORrisk and pregnancy success.
Zhu Hu, Yuanyuan Yu, Guanyou Huang, Jinnan Li, Chao Yang, Aizhuan Long, Jia Tang, Tengxiang Chen, Shuyun Zhao, Tuo Zhang   +9 more
wiley   +1 more source

Integrated multi-omics analysis reveals complement component 3 as a central driver of immune dysregulation in polycystic ovary syndrome

Frontiers in Endocrinology
BackgroundPolycystic Ovary Syndrome (PCOS) is a prevalent endocrine disorder with a complex pathophysiology, affecting various aspects of women’s health.
Xuanpeng Zhao, Qingyan Meng, Shuang Liu, Linqi Cheng, Baoshan Li, Dongkai Cheng   +5 more
doaj   +1 more source

Methylglyoxal-Dependent Glycative Stress and Deregulation of SIRT1 Functional Network in the Ovary of PCOS Mice

Cells, 2020
Advanced glycation end-products (AGEs) are involved in the pathogenesis and consequences of polycystic ovary syndrome (PCOS), a complex metabolic disorder associated with female infertility.
Giovanna Di Emidio, Martina Placidi, Francesco Rea, Giulia Rossi, Stefano Falone, Loredana Cristiano, Stefania Nottola, Anna Maria D’Alessandro, Fernanda Amicarelli, Maria Grazia Palmerini, Carla Tatone   +10 more
doaj   +1 more source

Androgens and Hypertension in Men and Women: a Unifying View. [PDF]

, 2017
This review was designed to revaluate the androgen role on the mechanisms of hypertension and cardiovascular risks in both men and women. Sex steroids are involved in the regulation of blood pressure, but pathophysiological mechanism is not well ...
Carmina, E. 4., Gnessi, Lucio, Lanzolla, Giulia, Moretti, Costanzo, Moretti, Marta   +4 more
core   +1 more source

An Open‐Source Pipeline for Calcium Imaging and All‐Optical Physiology in Human Stem Cell‐Derived Neurons

Advanced Science, EarlyView.
This work introduces an open‐source all‐optical platform for functional phenotyping of human stem cell‐derived neurons. The system integrates optogenetics, calcium imaging, automated acquisition, and analysis to resolve single‐cell and network activity, enabling longitudinal measurements, disease modeling, and pharmacological screening in preclinical ...
Wardiya Afshar‐Saber, Federico M. Gasparoli, Ziqin Yang, Nicole A. Teaney, Rachel Hobson, Lahin Lalani, Gayathri Srinivasan, Dosh Whye, Ranit Karmakar, Elizabeth D. Buttermore, Kellen D. Winden, Cidi Chen, Mustafa Sahin   +12 more
wiley   +1 more source

Polycystic Ovary Syndrome and Reproductive Health: A Comprehensive Review

Clinical and Experimental Obstetrics & Gynecology
Objectives: Polycystic ovary syndrome (PCOS) is a prevalent and intricate endocrine disorder that impacts women of reproductive age. It is marked by various symptoms, including menstrual irregularities, hyperandrogenism, and metabolic ...
Ramadan S. Hussein, Salman Bin Dayel, Othman Abahussein   +2 more
doaj   +1 more source

Single‐Cell Transcriptomics Reveals FLS2‐Dependent Hypoxia Signaling and ERF13‐Mediated Transcription During flg22‐Triggered Immunity

Advanced Science, EarlyView.
This study employs sc‐RNA sequencing, genetics, and phenotyping to systematically map the cell‐type‐specific immune responses triggered by flg22. It reveals FLS2‐dependent transcriptional reprogramming in epidermal and mesophyll cells, and uncovers crosstalk between immune and hypoxia signaling pathways.
Yaping Zhou, Aizhi Qin, Mengfan Li, Qianli Zhao, Luyao Kong, Lulu Yan, Chunyang Li, Hao Liu, Yinpeng Zhang, Jiani Long, Mengyu Liao, Mengmeng Zhou, Xiaoli Fan, Baozhen Wang, Wenxuan Kang, Shui Wang, Zhixin Liu, Xuwu Sun   +17 more
wiley   +1 more source

Lean Polycystic Ovary Syndrome: A Narrative Review

Clinical and Experimental Obstetrics & Gynecology
Objectives: (1) To delineate the differences between lean and obese polycystic ovary syndrome (PCOS). (2) To review different modalities for management of infertility associated with PCOS.
Aboubakr Elnashar
doaj   +1 more source

A Comparison Between the Effects of Letrozole in Combination with Clomiphene and Letrozole Alone on Ovulation and Pregnancy in Infertile Patients with Polycystic Ovarian Syndrome: A Clinical Trial Study [PDF]

Journal of Mazandaran University of Medical Sciences, 2023
Background and purpose: Infertility is defined as the inability to conceive after 12 months of regular coitus. Anovulatory processes are the most common cause of infertility in women.
Marzieh Zamaniyan, Kosar Razian, Sepideh Peyvandi, Mahmood Moosazadeh, Masoomeh Hamedi, Mohammad Zahedi, Ensieh Fooladi   +6 more
doaj