Results 51 to 60 of about 100,175 (352)

Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

Advanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou, Weijie Yang, Na Liu, Qing Liu, Jiamin Jin, Chenqiong Zhao, Xiaoying Jin, Miao Gui, Haiyan Zhu, Songying Zhang, Yinli Zhang   +10 more
wiley   +1 more source

PCOS HASTALARINDA BİYOELEKTRİK İMPEDANS ANALİZİ İLE DEĞERLENDİRİLEN VÜCUT KOMPOZİSYONLARININ; METABOLİK, HORMONAL VE ANTROPOMETRİK ÖLÇÜMLERLE KARŞILAŞTIRILMASI

Journal of Contemporary Medicine, 2021
Amaç: Bu çalışmada, PCOS’lu ve sağlıklı kontrol grubu hastalarında, vücut kompozisyon parametreleri BIA (Biyoelektrik İmpedans Analizi) ile ölçülerek, metabolik, antropometrik ve hormonal parametrelerle karşılaştırılmıştır.
Mahmut Altuntaş, Hüseyin Aksoy
doaj  

Comparison of frequency domain parameters of heart rate variability between women with polycystic ovarian disease and apparently healthy women

Journal of Family Medicine and Primary Care, 2022
Background: Polycystic ovary syndrome (PCOS) patients shows common features like increased insulin resistance and adiposity, which have been known to correlate with sympathetic hyperactivity.
Ritu Tiwari, Manish Bajpai, Sunita Tiwari, Smriti Agrawal   +3 more
doaj   +1 more source

The effect of atorvastatin on pancreatic beta cell requirement in women with polycystic ovary syndrome [PDF]

, 2017
Background There is an increased risk of developing T2DM in women with polycystic ovary syndrome (PCOS) and there is evidence that statins improve metabolic parameters in these patients.
Atkin, Stephen L., Coady, Anne Marie, Kilpatrick, Eric S., Sathyapalan, Thozhukat   +3 more
core   +2 more sources

Perfluorooctanoic Acid Exposure Causes Macrophage Ammonia Retention and Induces Spontaneous Miscarriages

Advanced Science, EarlyView.
PFOA exposure induces pregnancy loss by promoting glutaminolysis, which further causes ammonia accumulation in macrophages. Cellular ammonia retention results in damage to mitochondria and lysosomes, which leads to cell death eventually. Impaired lysosomes also decrease the secretion of the Cathepsin B (CTSB), and attenuate macrophage infiltration and ...
Yongbo Zhao, Yijun Zhang, Hanyu Rao, Jiani Sun, Zhiyi Pan, Liping Jin, Yan Zhao   +6 more
wiley   +1 more source

Approach to patients with pseudo-Cushing’s states

Endocrine Connections, 2020
The distinction between pseudo-Cushing’s states (PCS) and Cushing’s syndrome (CS) poses a significant clinical challenge even for expert endocrino logists.
Carla Scaroni, Nora M Albiger, Serena Palmieri, Davide Iacuaniello, Chiara Graziadio, Luca Damiani, Marialuisa Zilio, Antonio Stigliano, Annamaria Colao, Rosario Pivonello   +9 more
doaj   +1 more source

Uncovering anorexia nervosa in a biofeedback clinic for bowel dysfunction [PDF]

, 2012
Biofeedback is a conservative treatment based on behavioural techniques, which can be used in the management of bowel dysfunction. This article reports the results of a retrospective review of the clinical notes of 87 female patients attending a ...
Chelvanayagam, Sonya, Collins, B., Duncan, J., O'Brien, L.   +3 more
core   +1 more source

A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity

Advanced Science, EarlyView.
We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim, Eun‐kyung Min, Choon‐Mi Lee, Chan Hum Park, Byung‐Chul Oh, YunJae Jung, In‐Sun Hong   +6 more
wiley   +1 more source

The Comparison of the Effects of Voluntary Running Wheel and Endurance Training on Il-6 and Testosterone Levels in the Rats With PCOS

Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk, 2021
Background and Aim: Polycystic Ovary Syndrome (PCOS) is an endocrine disorder in women of reproductive age. In cross-sectional and longitudinal studies, exercise training is an effective solution for treating and declining the symptoms.
Faranak Moradi, Ali Akbarnejad
doaj  

Effect of androgen treatment during foetal and/or neonatal life on ovarian function in prepubertal and adult rats [PDF]

, 2012
We investigated the effects of different windows of testosterone propionate (TP) treatment during foetal and neonatal life in female rats to determine whether and when excess androgen exposure would cause disruption of adult reproductive function ...
Abbott, Abbott, Abbott, Alan S McNeilly, Amanda J Drake, Anderson, Anderson, Baravalle, BARRACLOUGH, Beloosesky, BRAWER, Brawer, Carretero, Champagne, Childs, Durlinger, Faiman, Franks, Grossmann, Hillier, HIRSHFIELD, Hoepfner, Honnma, Levallet, Marie Broyde, McNeilly, Michelle Welsh, Misugi, Murray, Nelson, Nelson, Nilsson, Ota, Pepling, Pepling, Picon, Rey, Richard Sharpe, Roma, Rossetti, Scalzo, Schindler, Slob, Tetsuka, Victoria Tyndall, Webber, Welsh, Welsh, Wolf, Xia, Yan   +50 more
core   +3 more sources