Results 41 to 50 of about 3,602,392 (295)

Comparison of methods for in-house screening of HLA*B57:01 to prevent abacavir hypersensitivity in HIV-1 care [PDF]

, 2015
Abacavir is a nucleoside reverse transcriptase inhibitor used as part of combination antiretroviral therapy in HIV-1-infected patients. Because this drug can cause a hypersensitivity reaction that is correlated with the presence of the HLA-B*57:01 ...
Bonczkowski, Pawel, Callens, Steven, Coucke, Paul, De Spiegelaere, Ward, De Wit, Stephane, Emonds, Marie-Paule, Kabeya, Kabamba, Kiselinova, Maja, Malatinková, Eva, Philippé, Jan, Ruelle, Jean, SERMIJN, ERICA, Trypsteen, Wim, Van Acker, Petra, Van Sandt, Vicky, Vandekerckhove, Linos, Verhofstede, Chris, VERVISCH, KAREN, Vogelaers, Dirk   +18 more
core   +4 more sources

Expression-PCR (E-PCR): overview and applications. [PDF]

Genome Research, 1994
1Department of Immunology, Waiter Reed Army Institute of Research, Washington, D.C. 20307-5100; 2Tropical Disease Unit, Division of Infectious Diseases, The Toronto Hospital and The University of Toronto, Toronto, Ontario, Canada M5G 2C4 In vitro transcription and translation are powerful tools for examining the s t ructure-funct ion relationships of ...
David E. Lanar, Kevin C. Kain
openaire   +3 more sources

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

The CHREST model of active perception and its role in problem solving [PDF]

, 2001
We discuss the relation of TEC to a computational model of expert perception, CHREST, based on the chunking theory. TEC’s status as a verbal theory leaves several questions unanswerable, such as the precise nature of internal representations used, or ...
Cheng, PCH, Gobet, F, Lane, PCR
core  

Power Counting Regime of Chiral Effective Field Theory and Beyond [PDF]

, 2010
Chiral effective field theory complements numerical simulations of quantum chromodynamics (QCD) on a space-time lattice. It provides a model-independent formalism for connecting lattice simulation results at finite volume and a variety of quark masses to
Hall, J. M. M., Leinweber, D. B., Young, R. D.   +2 more
core   +2 more sources

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Learning-based constraints on schemata [PDF]

, 2000
Schemata are frequently used in cognitive science as a descriptive framework for explaining the units of knowledge. However, the specific properties which comprise a schema are not consistent across authors. In this paper we attempt to ground the concept
Cheng, PCH, Gobet, F, Lane, PCR
core   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

CHREST+: A simulation of how humans learn to solve problems using diagrams. [PDF]

, 2000
This paper describes the underlying principles of a computer model, CHREST+, which learns to solve problems using diagrammatic representations. Although earlier work has determined that experts store domain-specific information within schemata, no ...
Cheng, PCH, Gobet, F, Lane, PCR
core