Results 71 to 80 of about 22,249,811 (294)

Effects of Summer Transhumance of Dairy Cows to Alpine Pastures on Body Condition, Milk Yield and Composition, and Cheese Making Efficiency

Animals, 2019
Summer transhumance to alpine pastures (ALP) is widespread in dairy systems of alpine regions. This study aimed to investigate the effects of transhumance of Brown Swiss cows to ALP on the yield, composition, and coagulation properties of milk (MCP), and
Sudeb Saha, Nicolò Amalfitano, Enrico Sturaro, Stefano Schiavon, Franco Tagliapietra, Giovanni Bittante, Ilaria Carafa, Elena Franciosi, Luigi Gallo   +8 more
doaj   +1 more source

Dietary Protein Intake and Peritoneal Protein Losses in Peritoneal Dialysis Patients

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Peritoneal dialysis (PD) patients lose protein in their waste dialysate, potentially increasing their risk for malnutrition. We wished to determine whether there was any association between losses and dietary protein intake (DPI). Methods DPI was assessed from 24‐h dietary recall using Nutrics software.
Haalah Shaaker, Andrew Davenport
wiley   +1 more source

DataSheet_1_A CD64/FcγRI-mediated mechanism hijacks PD-1 from PD-L1/2 interaction and enhances anti-PD-1 functional recovery of exhausted T cells.pdf

, 2023
Therapeutic monoclonal antibodies (mAb) targeting the immune checkpoint inhibitor programmed cell death protein 1 (PD-1) have achieved considerable clinical success in anti-cancer therapy through relieving T cell exhaustion.
Alessandra Noto (7022864), Constantinos Petrovas (517531), Michel Obeid (14229623), Craig Fenwick (1792990), Victor Joo (13318521), Giuseppe Pantaleo (10464), Laurence de Leval (135768)   +6 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

PD-L1-expressing CD19⁺ correlated positively with PD-1-expressing CD8⁺ T cells in HIV-1⁺ individuals.

, 2018
(A) Correlation between frequencies of PD-L1 in CD19+ cells and PD-1 in CD4+ T cells and (B) Correlation between frequencies of PD-L1 in CD19+ cells and PD-1 in CD8+ T cells were determined in healthy individuals and in VL-HIV-1+ individuals ...
Marjorie Pion (153357), Adrián Prieto-Sánchez (5703779), Rafael Correa-Rocha (846632), Verónica Astrid Pérez-Fernández (5703776), Santiago Moreno-Guillen (5703782), Jacobo Lopez-Abente (5703770), Carolina Gutierrez (5703773), María-Ángeles Muñoz-Fernández (5703785)   +7 more
core   +1 more source

Serum immune mediators as novel predictors of response to anti-PD-1/PD-L1 therapy in non-small cell lung cancer patients with high tissue-PD-L1 expression [PDF]

, 2023
Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related morbidity and mortality worldwide. Immune checkpoint inhibitors (ICIs) including anti-PD-1 and anti-PD-L1 antibodies, have significantly changed the treatment outcomes with better ...
Raza, Afsheen, Suparna Hassnad (18021694), Kanbour, Aladdin, Al-Bozom, Issam, Issam Al-Bozom (4711098), Vijayakumar, Suma, Hydrose, Shereena, Hassnad, Suparna, Suma Vijayakumar (14442132), Mohsen, Reyad, Sirriya, Shaza Abu, Prabhu, Kirti S., Dina M. Abo El-Ella (18021685), Al Homsi, Ussama, Abo El-Ella, Dina M., Abualainin, Wafa, Al-Abdulla, Rajaa, Kirti S. Prabhu (4246144), Akbar, Shayista, Melissa Annrose Tauro (18021688), Al-Suwaidi, Aisha Khamis, Maysaloun Merhi (4246147), Shaza Abu Sirriya (18021691), Shahab Uddin (154400), Zar Gul, Abdul Rehman, Inchakalody, Varghese Philipose, Shayista Akbar (14442117), Shereena Hydrose (14442135), Afsheen Raza (492657), Varghese Philipose Inchakalody (14153292), Wafa Abualainin (14442141), Reyad Mohsen (14778049), Aladdin Kanbour (14442123), Mohamed Izham Mohamed Ibrahim (14158896), Demime, Said, Philip, Anite, Merhi, Maysaloun, Uddin, Shahab, Anite Philip (14442129), Ussama Al Homsi (14442150), Abdul Rehman Zar Gul (14777347), Said Demime (18021697), Tauro, Melissa Annrose, Rajaa Al-Abdulla (14442138), Aisha Khamis Al-Suwaidi (18021682), Mohamed Ibrahim, Mohamed Izham   +45 more
core   +1 more source

Quantification of the growth suppression of HER2+ breast cancer colonies under the effect of trastuzumab and PD-1/PD-L1 inhibitor

Frontiers in Oncology, 2022
IntroductionImmune checkpoint blockade (ICB)-based therapy is revolutionizing cancer treatment by fostering successful immune surveillance and effector cell responses against various types of cancers.
Regina Padmanabhan, Hadeel Kheraldine, Hadeel Kheraldine, Ishita Gupta, Ishita Gupta, Nader Meskin, Anas Hamad, Semir Vranic, Ala-Eddin Al Moustafa, Ala-Eddin Al Moustafa   +9 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Anti-PD-1

Current Oncology Reports, 2022
Purpose of Review: Emerging data indicate that immune checkpoint blockade (ICB) in patients with metastatic melanoma can be stopped electively or at the time of toxicity with an acceptable risk for progression. However, the optimal treatment duration remains to be defined.
Jansen, Y, van der Veldt, A A M, Awada, G, Neyns, B   +3 more
openaire   +2 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source