Results 61 to 70 of about 22,249,811 (294)

The PD‐1 pathway in tolerance and autoimmunity [PDF]

Immunological Reviews, 2010
Summary:  Regulatory T cells (Tregs) and the PD‐1: PD‐ligand (PD‐L) pathway are both critical to terminating immune responses. Elimination of either can result in the breakdown of tolerance and the development of autoimmunity. The PD‐1: PD‐L pathway can thwart self‐reactive T cells and protect against autoimmunity in many ways.
Loise M, Francisco, Peter T, Sage, Arlene H, Sharpe   +2 more
openaire   +2 more sources

PD-1 and PD-L1 expression.

, 2018
Whole blood was labeled to determine PD-1 and PD-L1 subsets. (A) Histogram plots representatives of one healthy individual and one VL-HIV-1+ individual. PD-L1+ and PD-L1hi were determined in CD4+, in CD8+ and CD19+ cells.
Marjorie Pion (153357), Adrián Prieto-Sánchez (5703779), Rafael Correa-Rocha (846632), Verónica Astrid Pérez-Fernández (5703776), Santiago Moreno-Guillen (5703782), Jacobo Lopez-Abente (5703770), Carolina Gutierrez (5703773), María-Ángeles Muñoz-Fernández (5703785)   +7 more
core   +1 more source

A Review of Mechanical Design Approaches for Balanced Robotic Manipulation

Robotics
Robot manipulators are suitable for many industrial tasks, such as assembly and pick-and-place operations. However, high-acceleration motions result in shaking forces and moments to the base, which can cause vibration of the manipulator and instability ...
Yash J. Vyas, Volkert van der Wijk, Silvio Cocuzza   +2 more
doaj   +1 more source

Bioinformatic analysis of PD-1 checkpoint blockade response in influenza infection

BMC Genomic Data, 2022
Background The programmed cell death 1 (PD-1)/PD-1 ligand 1 (PD-L1) signaling pathway is significantly upregulated in influenza virus infection, which impairs the antiviral response.
Huilin Ou, Keda Chen, Linfang Chen, Hongcheng Wu   +3 more
doaj   +1 more source

PD-1 and CXCR4 expression in PDAC tumors and PDOs.

, 2022
Operative human primary PDAC specimens and corresponding PDOs for hPT26 were serially sectioned and stained with multiplex IF. Both primary PDAC tissues and PDOs showed co-expression of PD-1 and CXCR4 (green + violet→ teal). These regions corresponded to
Michael J. Cavnar (4014821), Joseph Kim (17521), Prakash K. Pandalai (13014740), Megan M. Harper (13014734), Mei Gao (503320), Miranda Lin (13014737), Reema A. Patel (13014743)   +6 more
core   +1 more source

Safety and antitumor activity of the anti–PD-1 antibody pembrolizumab in patients with advanced, PD-L1–positive papillary or follicular thyroid cancer

BMC Cancer, 2019
Background Treatment options for advanced thyroid cancer refractory to standard therapies are limited. The safety and efficacy of pembrolizumab were evaluated in patients with advanced differentiated thyroid cancer expressing programmed death ligand 1 ...
Janice M. Mehnert, Andrea Varga, Marcia S. Brose, Rahul R. Aggarwal, Chia-Chi Lin, Amy Prawira, Filippo de Braud, Kenji Tamura, Toshihiko Doi, Sarina A. Piha-Paul, Jill Gilbert, Sanatan Saraf, Pradeep Thanigaimani, Jonathan D. Cheng, Bhumsuk Keam   +14 more
doaj   +1 more source

Analysis of Interaction Between Atmosphere and Sea Using The Delft3D Hydrodynamics Model for Mapping Coastal Flood Zone at Belawan Port and Coastal

Prisma Sains: Jurnal Pengkajian Ilmu dan Pembelajaran Matematika dan IPA IKIP Mataram, 2023
Belawan port and coastal areas were also not spared from the impact of the tidal flood. This study aims to determine the performance of the Delft3D hydrodynamic model in simulating sea level and waves in tidal floods at Belawan port and coastal area ...
Rizki Fadhillah Pratama Putra, Tulus Ikhsan Nasution, Syahrul Humaidi, Yahya Darmawan   +3 more
doaj   +1 more source

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

Claudin‐6 Protein Expression in Atypical Teratoid/Rhabdoid Tumors Is Strongly Enriched in the Molecular Subgroup AT/RT‐TYR

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Claudin‐6 has emerged as a promising immunotherapeutic target, yet protein‐level data in atypical teratoid/rhabdoid tumors (AT/RTs) have been inconsistent. We analyzed 36 well‐characterized AT/RT samples and found membranous claudin‐6 protein expression in 58% of cases, with striking enrichment in the molecular subgroup AT/RT‐TYR (100%) and ...
Victoria E. Fincke, Christian Thomas, Michael C. Frühwald, Pascal D. Johann, Martin Hasselblatt   +4 more
wiley   +1 more source

PD-1 and CXCR4 expression in PDAC cells and PDOs.

, 2022
(A) PD1 and CXCR4 were detected in PDAC cells and PDOs by western blot. Notably, different cell and PDO lines had unique expression patterns. MOLT-4 was used as a positive control for PD-1 and CXCR4.
Michael J. Cavnar (4014821), Joseph Kim (17521), Prakash K. Pandalai (13014740), Megan M. Harper (13014734), Mei Gao (503320), Miranda Lin (13014737), Reema A. Patel (13014743)   +6 more
core   +1 more source