Results 11 to 20 of about 1,052 (92)

Angiogenesis, Angiogenic Factors, and Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS). [PDF]

Int J Urol
ABSTRACT The etiology of IC/BPS is multifactorial; thus, pathophysiology‐based phenotyping is needed for tailored treatments of IC/BPS patients. In this regard, it is now generally agreed that, when focusing on inflammatory responses in the bladder mucosa, IC/BPS is divided into two major phenotypes.
Yoshimura N, Furuta A, Tobisawa Y, Igarashi T, Saito T, Ueda T.   +5 more
europepmc   +2 more sources

Animal Models of Hunner-Type Interstitial Cystitis. [PDF]

Int J Urol
ABSTRACT Background Animal models are crucial for mechanistic studies and therapeutic development of human diseases. At present, the etiology of interstitial cystitis/bladder pain syndrome (IC/BPS), a chronic disease of the urinary bladder, remains undefined.
Akiyama Y, Luo Y.
europepmc   +2 more sources

Tumor Anti-Angiogenesis Therapy and Its Influence on Immune Cell Function in the Tumor Microenvironment. [PDF]

Cancer Med
ABSTRACT Vascular normalization, one promising anti‐angiogenic strategy, has the potential to enhance vascular perfusion and elevate the infiltration of immune cells into tumors by rectifying aberrant tumor blood vessels. This results in the enhancement of immunotherapy.
Tang Y, Ding Y, Wang L, Yang Y, Han Y, Zhou P, Qu H, Deng K, Xia J.   +8 more
europepmc   +2 more sources

HLA-DR-Expressing Fibroblast-Like Synoviocytes Are Inducible Antigen Presenting Cells That Present Autoantigens in Lyme Arthritis. [PDF]

ACR Open Rheumatol
Objective HLA‐DR–expressing fibroblast‐like synoviocytes (FLS) are a prominent cell type in synovial tissue in chronic inflammatory forms of arthritis. FLS‐derived extracellular matrix (ECM) proteins, including fibronectin‐1 (FN1), contain immunogenic CD4+ T cell epitopes in patients with postinfectious Lyme arthritis (LA).
Rouse JR, Danner R, Wahhab A, Pereckas M, Nguyen C, McClune ME, Steere AC, Strle K, Jutras BL, Lochhead RB.   +9 more
europepmc   +2 more sources

Hypoxia signaling in cancer: Implications for therapeutic interventions

MedComm, Volume 4, Issue 1, February 2023., 2023
Solid tumors gradually form a hypoxic malignant microenvironment during growth, which promotes tumor proliferation and metastasis by affecting metabolism, angiogenesis, and immune escape, and finally leads to therapeutic resistance. In recent years, hypoxia‐inducible factor inhibitors, direct targeting of hypoxic cells, and respiratory hyperoxia have ...
Yan Zhuang, Kua Liu, Qinyu He, Xiaosong Gu, Chunping Jiang, Junhua Wu   +5 more
wiley   +1 more source

TGFβ+ small extracellular vesicles from head and neck squamous cell carcinoma cells reprogram macrophages towards a pro‐angiogenic phenotype

Journal of Extracellular Vesicles, Volume 11, Issue 12, December 2022., 2022
Abstract Transforming growth factor β (TGFβ) is a major component of tumor‐derived small extracellular vesicles (TEX) in cancer patients. Mechanisms utilized by TGFβ+ TEX to promote tumor growth and pro‐tumor activities in the tumor microenvironment (TME) are largely unknown.
Nils Ludwig, Saigopalakrishna S. Yerneni, Juliana H. Azambuja, Monika Pietrowska, Piotr Widłak, Cynthia S. Hinck, Alicja Głuszko, Mirosław J. Szczepański, Teresa Kärmer, Isabella Kallinger, Daniela Schulz, Richard J. Bauer, Gerrit Spanier, Steffen Spoerl, Johannes K. Meier, Tobias Ettl, Beatrice M. Razzo, Torsten E. Reichert, Andrew P. Hinck, Theresa L. Whiteside   +19 more
wiley   +1 more source

Bioactive food components and their inhibitory actions in multiple platelet pathways

Journal of Food Biochemistry, Volume 46, Issue 12, December 2022., 2022
A comprehensive overview of platelet multifunctional roles in CVD and other diseases and the effects of food components' modulatory effects are described. Abstract In addition to hemostasis and thrombosis, blood platelets are involved in various processes such as inflammation, infection, immunobiology, cancer metastasis, wound repair and angiogenesis ...
Diptimayee Das, Shubhamay Adhikary, Ranjit Kumar Das, Antara Banerjee, Arun Kumar Radhakrishnan, Sujay Paul, Surajit Pathak, Asim K. Duttaroy   +7 more
wiley   +1 more source

Probiotic Lactobacillus rhamnosus GG (LGG) restrains the angiogenic potential of colorectal carcinoma cells by activating a proresolving program via formyl peptide receptor 1

Molecular Oncology, Volume 16, Issue 16, Page 2959-2980, August 2022., 2022
The commensal probiotic bacteria Lactobacillus rhamnosus GG (LGG), by activating the innate immune receptor formyl peptide receptor 1 (FPR1), influence normal intestinal epithelial homeostasis and sustain wound restitution. We demonstrated that LGG, but not other lactic acid or nonprobiotic bacteria, activate an inflammation resolution program that ...
Federica Liotti, Maria Marotta, Daniela Sorriento, Chiara Pagliuca, Valeria Caturano, Giuseppe Mantova, Elena Scaglione, Paola Salvatore, Rosa Marina Melillo, Nella Prevete   +9 more
wiley   +1 more source

Regeneration of temporomandibular joint using in vitro human stem cells: A review

Journal of Tissue Engineering and Regenerative Medicine, Volume 16, Issue 7, Page 591-604, July 2022., 2022
Abstract Temporomandibular joint disorders (TMDs) range from gross anatomic deformities of the disc and hard tissue to functional disturbances. Traditional treatment of TMDs includes physical therapy, use of appliances, pharmacological, surgical and psychological interventions.
Shan Gong, Chitra Priya Emperumal, Kamal Al‐Eryani, Reyes Enciso   +3 more
wiley   +1 more source

Characterization of the Angiogenic Potential of Human Regulatory Macrophages (Mreg) after Ischemia/Reperfusion Injury In Vitro

Stem Cells International, Volume 2019, Issue 1, 2019., 2019
Ischemia/reperfusion‐ (I/R‐) induced organ damage represents one of the main causes of death worldwide, and new strategies to reduce I/R injury are urgently needed. We have shown that programmable cells of monocytic origin (PCMO) respond to I/R with the release of angiogenic mediators and that transplantation of PCMO results in increased ...
Lars Hummitzsch, Karina Zitta, Rene Rusch, Jochen Cremer, Markus Steinfath, Justus Gross, Fred Fandrich, Rouven Berndt, Martin Albrecht, Luca Vanella   +9 more
wiley   +1 more source