Results 21 to 30 of about 1,052 (92)

Effects of collagen peptides intake on skin ageing and platelet release in chronologically aged mice revealed by cytokine array analysis

open access: yesJournal of Cellular and Molecular Medicine, Volume 22, Issue 1, Page 277-288, January 2018., 2018
Abstract Action mechanisms underlying various biological activities of collagen peptides (CPs) remained to be elucidated. Cytokines may play an important role in mediating these health benefits of CPs. This study aimed to systemically examine the cytokines in skin and blood regulated by CPs intake.
Hongdong Song   +4 more
wiley   +1 more source

Immune Condition of Colorectal Cancer Patients Featured by Serum Chemokines and Gene Expressions of CD4+ Cells in Blood

open access: yesCanadian Journal of Gastroenterology and Hepatology, Volume 2018, Issue 1, 2018., 2018
Background. Colorectal cancer (CRC), the most common malignancy worldwide, causes inflammation. We explored the inflammatory pathophysiology of CRC by assessing the peripheral blood parameters. Methods. The differences in gene expression profiles of whole blood cells and cell subpopulations between CRC patients and healthy controls were analyzed using ...
Takuya Komura   +12 more
wiley   +1 more source

The Danger Model Approach to the Pathogenesis of the Rheumatic Diseases

open access: yesJournal of Immunology Research, Volume 2015, Issue 1, 2015., 2015
The danger model was proposed by Polly Matzinger as complement to the traditional self‐non‐self‐ (SNS‐) model to explain the immunoreactivity. The danger model proposes a central role of the tissular cells’ discomfort as an element to prime the immune response processes in opposition to the traditional SNS‐model where foreignness is a prerequisite ...
César Pacheco-Tena   +2 more
wiley   +1 more source

Prognosis Relevance of Serum Cytokines in Pancreatic Cancer

open access: yesBioMed Research International, Volume 2015, Issue 1, 2015., 2015
The overall survival of patients with pancreatic ductal adenocarcinoma is extremely low. Although gemcitabine is the standard used chemotherapy for this disease, clinical outcomes do not reflect significant improvements, not even when combined with adjuvant treatments. There is an urgent need for prognosis markers to be found. The aim of this study was
Carolina Torres   +13 more
wiley   +1 more source

Investigation of the Lower Resistance Meridian: Speculation on the Pathophysiological Functions of Acupuncture Meridians

open access: yesEvidence-Based Complementary and Alternative Medicine, Volume 2014, Issue 1, 2014., 2014
It was pointed out in the two earlier papers of the present author that the meridians are in fact zones in the loose connective tissue containing richer interstitial fluid and thus are lower‐resistance passages for diffusion of meridian‐signal carriers or mediators.
Weisheng Yang, Younbyoung Chae
wiley   +1 more source

Mapping and Identification of the Urine Proteome of Prostate Cancer Patients by 2D PAGE/MS

open access: yesInternational Journal of Proteomics, Volume 2014, Issue 1, 2014., 2014
Proteome analysis of the urine has shown that urine contains disease‐specific information for a variety of urogenital system disorders, including prostate cancer (PCa). The aim of this study was to determine the protein components of urine from PCa patients.
Sanja Kiprijanovska   +7 more
wiley   +1 more source

Inflammation and epithelial–mesenchymal transition in a CFTR‐depleted human bronchial epithelial cell line revealed by proteomics and human organ‐on‐a‐chip

open access: yesThe FEBS Journal, Volume 292, Issue 19, Page 5086-5104, October 2025.
Proteomic analysis of cystic fibrosis transmembrane conductance regulator knockout (CFTR‐KO) clones of 16HBE14o‐ cells showed altered pathways linked to inflammation, polymorphonuclear leukocyte (neutrophil) recruitment, and epithelial–mesenchymal transition.
Domenico Mattoscio   +19 more
wiley   +1 more source

Analysis of the mRNA Expression of Chemotherapy‐Related Genes in Colorectal Carcinoma Using the Danenberg Tumor Profile Method

open access: yesJournal of Oncology, Volume 2013, Issue 1, 2013., 2013
The establishment of individualized chemotherapy for colorectal carcinoma based on the expression of genes involved in chemotherapeutic sensitivity or prognosis is necessary. To achieve this, the expression profiles of genes within tumors and their relationship to clinicopathological factors must be elucidated.
Shin Sasaki   +3 more
wiley   +1 more source

Platelets and Their Role in Immunity: Formation, Activation and Activity, and Biologically Active Substances in Their Granules and Extracellular Vesicles

open access: yesInternational Journal of Inflammation, Volume 2025, Issue 1, 2025.
When presenting the role of platelets in immunity, the organelles and processes occurring within them are listed, and due to their lack of a cell nucleus, their specific transcriptional activity is discussed. Their formation, activation, and functional activity are also described, along with the characterization of elements important for shaping their ...
Beata Tokarz-Deptuła   +7 more
wiley   +1 more source

Interplay between CKS2, N-cadherin, and PD-ECGF in Non-Schistosomal and Schistosomal-Associated Bladder Cancer: A Prospective Comparative Study in the Egyptian Population

open access: yesMiddle East Journal of Cancer, 2017
Background: The current study investigated the possible role of the cell cycle regulator, cyclin-dependent kinases regulatory subunit-2; the angiogenic factor, plateletderived endothelial cell growth factor; and the cell adhesive molecule, neural ...
Sanaa Shawky   +5 more
doaj  

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