Results 261 to 270 of about 264,642 (338)

A Focus on PD-L1 in Human Melanoma

, 2012
Peter Hersey, Stuart Gallagher
openalex   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

KRAS mutations promote PD-L1-mediated immune escape by ETV4 in lung adenocarcinoma. [PDF]

Transl Oncol
Jia D, Wang P, Zheng S, Lei Z, Xu W, Wang Y, Pan X, Feng Q, Yang J.   +8 more
europepmc   +1 more source

Chronic ER Stress Triggers Cell‐Surface Chaperones as the Therapeutic Targets of CAR Cells in Acute Myeloid Leukemia

Advanced Science, EarlyView.
Acute myeloid leukemia (AML) remains a therapeutic challenge due to its heterogeneity and limited targets. Here, multi‐omics analyses are utilized, and it is revealed that AML cells, particularly the FLT3‐ITD+ subtype, undergo chaperone‐mediated ER stress, inducing surface translocation of ER chaperones.
Yimin Zhou, Zhenfei Zhong, Peng Hu, Weigang Wang, Ying Song, Na Yang, Fangyan He, Yajie Li, Qi Sa, Yanmei Yang, Qinmiao Sun, Tonghua Yang, Beibei Zhang, Dahua Chen   +13 more
wiley   +1 more source

Anti PD-L1 immunotherapy alters macrophage phenotypes via EGR1 and HSP90AB1 supported by integrated methodologies. [PDF]

Sci Rep
Shou X, Wang Y, Zhou Z, Liu J, Zhang D, Yang Z, Liu Q.   +6 more
europepmc   +1 more source

Concomitant Inhibition of mTORC1 and mTORC2 in Dendritic Cells Reduces SOCS3 Expression Resulting in Enhanced Immunoregulatory PD-L1 Expression and IL-10 Secretion

, 2012
Brian Rosborough, Benjamin M. Matta, Hēth Turnquist, Angus W. Thomson   +3 more
openalex   +1 more source

Sequential Tumor Microenvironment Reprogramming by Nanoplatform Potentiates Sonodynamic‐Chemodynamic Therapy and Immune Checkpoint Blockade in Breast Cancer

Advanced Science, EarlyView.
A modular nanoplatform capable of sequentially reprogramming tumor microenvironment via cascade actions and responsive therapeutic functions is reported for breast cancer therapy. Via a dual‐targeting mechanism and responsive PD‐L1 antibody release, this nanoplatform enables amplified sonodynamic‐chemodynamic therapy and elicits robust immune response ...
Yang Yu, Zheming Song, Anni Zhu, Jingchao Li, Rujia Fan, Bing Xiao   +5 more
wiley   +1 more source

PD-L1(+) tumor-associated macrophages induce CD8(+) T Cell exhaustion in hepatocellular carcinoma. [PDF]

Neoplasia
Nosaka T, Ohtani M, Yamashita J, Murata Y, Akazawa Y, Tanaka T, Takahashi K, Naito T, Imamura Y, Koneri K, Goi T, Nakamoto Y.   +11 more
europepmc   +1 more source

Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti–PD-L1 immunotherapy in pancreatic cancer

, 2013
Christine Feig, James O. Jones, Matthew Kraman, R. J. Wells, Andrew Deonarine, Derek Chan, Claire M. Connell, Edward W. Roberts, Qi Zhao, Otávia L. Caballero, Sarah A. Teichmann, Tobias Janowitz, Duncan I. Jodrell, David A. Tuveson, Douglas T. Fearon   +14 more
openalex   +1 more source

Mechanotransduction in Shaping Immunity: Pathways, Crosstalk, and Pathophysiological Relevance

Advanced Science, EarlyView.
This review comprehensively summarizes the role of mechanotransduction in shaping immunity. It details how immune cells respond to biomechanical cues via mechanotransduction cascades and emphasizes the mechanical crosstalks within the immune microenvironment. The emerging significance of mechanoimmunology in both health and diseases is also highlighted.
Ruijiao Yan, Yuyu Li, Shuo Chen, Li Zhu, Chenchen Zhou, Jianwei Chen, Shujuan Zou, Xianglong Han   +7 more
wiley   +1 more source