Results 261 to 270 of about 276,897 (341)

Dynamic PD-L1 Regulation Shapes Tumor Immune Escape and Response to Immunotherapy. [PDF]

Cancers (Basel)
Pell B, Kalizhanova A, Tursynkozha A, Dengi D, Kashkynbayev A, Kuang Y.   +5 more
europepmc   +1 more source

GlycoChat Uncovers Glycan–Lectin Circuits in the Tumor Microenvironment of Pancreatic Cancer

Advanced Science, EarlyView.
Aberrant glycosylation drives cancer progression, yet its role in the tumor microenvironment remains unclear. We developed GlycoChat to map glycan–lectin circuits at single‐cell resolution. We discovered that cancer cells induce immunosuppressive macrophage differentiation and impair phagocytosis through interactions with CLEC10A and SIGLEC3 ...
Dinh Xuan Tuan Anh, Sunanda Keisham, Arun Burramsetty, Lalhaba Oinam, Koichiro Kumano, Akihiro Kuno, Osamu Shimomura, Tatsuya Oda, Hiroaki Tateno   +8 more
wiley   +1 more source

Mycobacterium avium infection induced PD-L1 overexpression in macrophages: a potential involvement with immune escape. [PDF]

Cell Death Dis
Yano H, Fujiwara Y, Mito R, Pan C, Ono K, Imamura K, Niidome T, Sawa T, Yamamoto M, Sakagami T, Komohara Y.   +10 more
europepmc   +1 more source

MCUB Inhibits PRKN‐Dependent Mitophagic Degradation of PD‐L1 to Promote Immune Evasion in Bladder Cancer

Advanced Science, EarlyView.
In bladder cancer, the overexpression of MCUB not only reduces mitochondrial calcium influx but also facilitates its binding to PRKN at Arg51, both mechanisms contribute to the impairment of PRKN‐mediated mitophagy. Consequently, the degradation of PD‐L1 is suppressed, leading to its stable expression on the tumor cell surface.
Yuan Huang, Chen Chen, Mingqiang Su, Dongqing Li, Jinge Zhang, Kuangye Long, Wenbin Nie, Shu Wei, Wei Chen, Haiyong Chen, Zhangfeng Zhong, Lina Hou, Wanlong Tan, Fei Li   +13 more
wiley   +1 more source

AI driven pre-regulatory validation of PD-L1 analysis in lung cancer. [PDF]

Sci Rep
Makhlouf Y, Maxwell P, O'Reilly P, Geaney A, James JA, Salto-Tellez M.   +5 more
europepmc   +1 more source

CD20+FCRL4+ B Cells Activate CD8+ T Cells via MHC‐I Restriction in Nasopharyngeal Carcinoma Anti‐Tumor Immunity

Advanced Science, EarlyView.
CD20⁺FCRL4⁺ B cells in nasopharyngeal carcinoma actively cross‐present exogenous tumor antigens via MHC‐I, enhancing CD8⁺ T‐cell activation, memory formation, and cytotoxicity. IFNγ‐driven WDFY4 upregulation facilitates this process. These findings reveal an unconventional B‐cell–mediated antitumor mechanism and indicate potential relevance to ...
Benjian Zhang, Xiaotian Yuan, Kelei Gao, Bo You, Yaxuan Wang, Lai Meng, Zirong Chen, Shaobing Xie, Yunqing Liu, Zijian Dong, Shumin Xie, Ruohao Fan, Fengjun Wang, Junyi Zhang, Zhihai Xie, Yongzhen Mo, Hua Zhang, Weihong Jiang   +17 more
wiley   +1 more source

PD-L1 expression in gastric cancer assessed with antibodies 28-8 and 22C3. [PDF]

Sci Rep
Cantor EA, Bejarano-Ramírez AF, Zambrano LC, Triana IC, Vargas HA, Segovia JM, Pino LE, Murillo JA, López R.   +8 more
europepmc   +1 more source

Peer Review #2 of "CMTM6 significantly relates to PD-L1 and predicts the prognosis of gastric cancer patients (v0.2)"

, 2020

openalex   +2 more sources

Advanced Human Immune Cell‐Organoid Co‐Cultures for Functional Testing of Cancer Nanovaccines

Advanced Science, EarlyView.
Pancreatic ductal adenocarcinoma remains difficult to treat. We establish an organoid–immune co‐culture using patient‐derived organoids and matched T‐cells to assess cancer vaccines. A mesothelin‐targeted nanovaccine activates antigen‐specific T‐cells, increases IFN‐γ, and targets MSLN+ organoids.
Nathalia Ferreira, David Agorku, Andre Rosa, Julia Roosz, Lena Christ, Nicole Anderle, Ajinkya Kulkarni, Abir Hussein, Sana S. Sayedipour, Omar F. Luna, Tobias Legler, Philipp Ströbel, Fernando Albericio, Luis Cruz, Phillipp Beckhove, Peter Loskill, Frauke Alves, M. Andrea Markus, Fernanda Ramos‐Gomes   +18 more
wiley   +1 more source

A bifunctional peptide-selenium nanocomposite for lysosomal degradation of PD-L1 and enhanced cancer immunotherapy. [PDF]

Front Immunol
Wang Y, Feng J, Yan J, You W, Yan S.
europepmc   +1 more source