Results 271 to 280 of about 276,897 (341)

PRDM1+ Malignant Cells Mediate an Immunosuppressive Landscape and Resistance to Neoadjuvant Chemoradiotherapy and Immunotherapy in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
Integrated scRNA‐seq, scTCR‐seq analysis, and functional assays identify PRDM1+ malignant epithelial cells with hyper lipid peroxidation characteristics that demonstrate reduced responsiveness to the nICRT treatment. Principal factor PRDM1 activates cysteine metabolism genes to modulate lipid peroxidation (an intrinsic cellular pathway related to ...
Dijian Shen, Rui Li, Yong She, Xuefei Liu, Yuanyang Huang, Yongling Ji, Keying Chen, Zhengbo Song, Runzhe Chen, Xuan Li, Qi Zhao, Qixun Chen, Ming Chen   +12 more
wiley   +1 more source

PTPN22 Dephosphorylates CBL to Inhibit PD-L1 Ubiquitination and Drive Immunosuppression in Renal Cell Carcinoma. [PDF]

Int J Biol Sci
Jin T, Ma J, Wang L, Liu X, Wu M, Wang B, Gao C, Zhu S, Zhang R, Xia F, Tian J, Zhu W, Jin J, He Q.   +13 more
europepmc   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Unraveling the complexity of PD-L1 assays: a descriptive review of the methodology, scoring, and practical implications. [PDF]

Front Oncol
Vainer GW, Badve SS, Rajadurai P, Soares FA, Viale G, Büttner R, Nuti S, Juco J, Krishnan R, Tsao MS.   +9 more
europepmc   +1 more source

Decoding Triphenotypic Neutrophils in Cervical Cancer Evolution and Targeting SPP1+/GBP1+/ELOVL5+ Tumor‐Associated Neutrophils to Sensitize Immunotherapy

Advanced Science, EarlyView.
The functional schematic diagram of tumor associated neutrophils. Abstract Enhancing cervical cancer (CC) immunotherapy requires deciphering the heterogeneous tumor immune microenvironment (TIME), particularly neutrophil phenotypic dynamics. Here, 1) we collected 543 CC cases to find that patients with elevated neutrophil levels have a higher incidence
Xingyu Chang, Xinyu Qu, Tingting Ren, Tong Wu, Weiyong Gu, Jingxin Ding, Keqin Hua, Junjun Qiu   +7 more
wiley   +1 more source

Regulation of PD-L1 Protein Expression by the E3 Ubiquitin Ligase GP78. [PDF]

Curr Issues Mol Biol
Chatterjee M, Pimentel JM, Zhou JY, Mugunamalwaththa T, Yang Z, Raz A, Wu GS.   +6 more
europepmc   +1 more source

Pathomics Signature for Prognosis and CA19‐9 Interception in Pancreatic Ductal Adenocarcinoma: A Real‐Life, Multi‐Center Study

Advanced Science, EarlyView.
This study develops a deep learning‐based pathomics model to predict survival outcomes in pancreatic cancer patients. The CrossFormer architecture analyzes routine H&E‐stained tissue slides, identifying key prognostic features including stromal patterns, cellular characteristics, and immune infiltration.
Qiangda Chen, Zhihang Xu, Yiping Zou, Zhenlai Jiang, Yecheng Li, Taochen He, Hanlin Yin, Jiali Li, Yanfei An, Jiande Han, Yuqi Xie, Wei Gan, Yaolin Xu, Wenquan Wang, Junyi He, Haibo Wang, Wenchuan Wu, Zhenyu Ye, Wenhui Lou, Jihui Hao, Liang Liu, Jun Yu, Ning Pu   +22 more
wiley   +1 more source

Beyond monoclonal antibodies: constraints and the case for alternative PD-1/PD-L1-targeting formats. [PDF]

Front Immunol
Porozova NO, Petukhova NV, Gureev MA, Moiseev IS, Eliseev IE, Fedorova LV, Porozov YB.   +6 more
europepmc   +1 more source

Clinicopathological and prognostic value of PD-L1 in urothelial carcinoma: a meta-analysis

, 2019
Xuansheng Ding, Qian Chen, Zhen Yang, Li J, Haocheng Zhan, Nianli Lu, Mark Chen, Yunpeng Yang, Jiguang Wang, Dong‐Hua Yang   +9 more
openalex   +1 more source

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

Advanced Science, EarlyView.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang, Jiangang Xu, Xinyu Zhou, Lu Che, Minghan Qiu, Yang Liu, Ming Gao, Zhen Yang   +7 more
wiley   +1 more source