Results 291 to 300 of about 264,642 (338)

GBP1-CDK9-STAT3 signaling axis promotes osteosarcoma PD-L1 expression and immune escape. [PDF]

Neoplasia
Jing D, Chen B, Liang R, Li F, Zhao B, Pu F, Wu W.   +6 more
europepmc   +1 more source

Light Metabolically Reprograms CD8+ T Cells to Potentiate STING‐Driven Tumor Eradication and Prevent Metastasis

Advanced Science, EarlyView.
Low‐level light (LLL) rejuvenates exhausted CD8+ T cells, boosting STING‐driven tumor eradication and prevents metastasis. NanoSTING@Mn enhances CD8+ T cells infiltration while LLL restores its function expanding to progenitor‐exhausted cells. These cells form central memory T cells in lymphoid organs. Intranasal nanoSTING@Mn redirects antitumor CD8+ T
Asmita Banstola, Shilin Gao, Zhengkung Zhang, Yan Dong, Prabhat Upadhyay, Quanwei Zhang, Yongli Li, Zuan‐Tao Lin, Zhilong Wang, Mei X. Wu   +9 more
wiley   +1 more source

Munc13-4 mediates tumor immune evasion by regulating the sorting and secretion of PD-L1 via exosomes. [PDF]

Nat Commun
Liu C, Liu D, Zheng X, Guan J, Zhou X, Zhang H, Wang S, Li Q, Lu G, He J, Ma C.   +10 more
europepmc   +1 more source

Interference with PD-L1/PD-1 co-stimulation during antigen presentation enhances the multifunctionality of antigen-specific T cells

, 2014
Joeri J. Pen, Brenda De Keersmaecker, Carlo Heirman, Jurgen Corthals, Thérèse Liechtenstein, David Escors, Kris Thielemans, Karine Breckpot   +7 more
openalex   +1 more source

Micro/Nanorobots for Combating Brain Disorders: Challenges, Advances, and Perspectives

Advanced Science, EarlyView.
Micro/nanorobots (MNRs) offer a transformative approach for precision therapy in brain disorders. By overcoming biological barriers and enabling controlled propulsion, targeted delivery, and real‐time imaging/tracking, MNRs pave the way toward effective, minimally invasive treatments. This review outlines the interplay between brain disease challenges,
Qi Zhang, Dong Sun
wiley   +1 more source

USP5-Mediated PD-L1 deubiquitination regulates immunotherapy efficacy in melanoma. [PDF]

J Transl Med
Xie J, Zhang P, Liu Y, Wu D, Ou X, Wang M, Yan W, Liu J, Tang J, Ni T, Ma C, Tang Q, Zhao S, Qi M.   +13 more
europepmc   +1 more source

An unbalanced PD-L1/CD86 ratio in CD14++CD16+ monocytes is correlated with HCV viremia during chronic HCV infection

, 2014
Jiajia Zheng, Hua Liang, Chunhui Xu, Qiang Xu, Ting Zhang, Tao Shen, Fengmin Lu   +6 more
openalex   +1 more source

In Situ Assembly of Transformable Monopeptide on Activated Neutrophils Attenuates NETs‐Induced Hepatocellular Carcinoma Metastasis by Disrupting NE Nuclear Translocation

Advanced Science, EarlyView.
Activated neutrophils release extracellular traps (NETs) that promote tumor metastasis. FTP‐NPs are develpoed, a peptidic nanomaterial that binds NE on neutrophil membranes, forming NE‐fibril clusters that deactivate NE and prevent NETs formation. This strategy reduces metastasis and enhances the anti‐tumor immune response by targeting NE subcellular ...
Yichi Chen, Yijun Wang, Haitao Shang, Jiayue Qiu, Ruotian Zhang, Yuxiang Xiong, Tong Wang, Fengyi Wang, Anbang Wu, Xin Lin, Bolin Wu, Chen Huang, Wen Cheng, Lu Zhang   +13 more
wiley   +1 more source

Using extension-based mRNA display to design antibody-like proteinogenic peptides for human PD-L1. [PDF]

Protein Sci
Ong JN, Grindel BJ, Rankin SA, Naylon SH, Srinivasamani A, Trusz GJ, Liang X, Uddin MN, Fuller L, Curran M, Roche SP, Takahashi TT, Roberts RW, Millward SW.   +13 more
europepmc   +1 more source

Essential Updates 2023/2024: Recent Advances of Multimodal Approach in Patients for Gastric Cancer

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Gastric cancer remains a major global health burden, especially in East Asia. Recent years have brought significant advances in multimodal management, including surgery, perioperative chemotherapy, immunotherapy, and supportive care. This review summarizes key updates from 2023 to 2024, focusing on surgical innovations, perioperative systemic ...
Katsutoshi Shoda, Yoshihiko Kawaguchi, Suguru Maruyama, Daisuke Ichikawa   +3 more
wiley   +1 more source