Results 301 to 310 of about 276,897 (341)

EVI5 unveils a role of the oncogene in modulating the Rab11/PD-L1 pathway in lung adenocarcinoma. [PDF]

Sci Rep
Cai T, Xu Y, Zhang P, Zhang X, Xie J, Liu H, He Q, Shi Y, Qi Y, Li Q, Zhou J, Li C.   +11 more
europepmc   +1 more source

Multifunctional Nano Immunostimulant: Overcoming Immunosuppressive Microenvironment for Antitumor Immunotherapy

Advanced Science, EarlyView.
A multifunctional nano immunostimulant is first proposed for efficient tumor immunotherapy. The ER targeted ability, superior ROS production, efficient GSH consumption, coupled with the HIF suppression, jointly arouses ICD/ferroptosis pathways to realize efficient tumor immunotherapy.
Guanhong Guo, Wenda Zhong, Huishuang Zhao, Yueying An, Xinyu Dong, Zhengbo Li, Shuangfeng Qin, Guangzhao Xu, Xiangguo Yue, Xudong Wang, Wen Sun, Zhe‐Sheng Chen, Weiguo Song, Liuya Wei, Fahui Li   +14 more
wiley   +1 more source

PD-L1 expression as a prognostic factor for postoperative outcomes in pleural mesothelioma. [PDF]

Transl Lung Cancer Res
Kanayama M, Manabe T, Yoshimatsu K, Nemoto Y, Matsumiya H, Mori M, Takenaka M, Kuroda K, Tanaka F.   +8 more
europepmc   +1 more source

Ultra‐Sensitive Dual‐Resonator Graphene Pressure Sensor with Temperature Self‐Compensation

Advanced Science, EarlyView.
This work presents a graphene resonator sensor based on a dual‐cavity interferometric scheme that achieves high sensitivity to pressure variations. Its lightweight and compact design enables drone‐based field experiments, underscoring the promise of graphene optomechanical devices for portable and scalable sensing applications.
Zhen Wan, Cheng Li, Zhengwei Wu, Pengcheng Zhao, Yang Liu, Wanting Li, Shangchun Fan, Wei Jin   +7 more
wiley   +1 more source

Computational identification and evaluation of novel PD-L1 inhibitors for cancer immunotherapy. [PDF]

Sci Rep
Manzoor H, Khan MU, Shabbir CA, Rehman R, Alhegaili AS, Ullah MI, Ghanem HB, Alameen AAM.   +7 more
europepmc   +1 more source

Biomimetic Nanomedicine for Senescence‐Modulated Immune Activation Enhances Immunotherapy Efficacy in Hepatocellular Carcinoma

Advanced Science, EarlyView.
A multifunctional mPDZM nanoplatform is developed in this study. mPDZM integrates chemotherapy‐induced senescence, selective senolysis, and STING‐mediated immune activation. mPDZM effectively clears senescent tumor cells, remodels the tumor immune microenvironment, and enhances antitumor T‐cell responses.
Shiji Fang, Liyun Zheng, Bin Lin, Jiale Chen, Dehai Hou, Yiming Ding, Mengzhu Han, Pan Qin, Mengyuan Wang, Xiaoju Guo, Yeyu Zhang, Gaofeng Shu, Fazong Wu, Jianfei Tu, Minjiang Chen, Zhongwei Zhao, Zhuang Liu, Jiansong Ji   +17 more
wiley   +1 more source

Predicability of PD-L1 expression in cancer cells based solely on H&E-stained sections. [PDF]

J Pathol Inform
Faa G, Fraschini M, Ziranu P, Pretta A, Porcu G, Saba L, Scartozzi M, Shokun N, Rugge M.   +8 more
europepmc   +1 more source

Fe‐S Protein FDX1 Triggers Tumor‐Intrinsic Innate Immunity via Mitochondrial Nucleic Acids Release to Orchestrate Ferroptosis in CCRCC

Advanced Science, EarlyView.
Restoration of the mitochondrial Fe–S protein FDX1 suppresses clear cell renal cell carcinoma by coupling ferroptosis with tumor‐intrinsic innate immune activation. FDX1 induces mitochondrial dysfunction and mtDNA/mt‐dsRNA release, activating cGAS–STING and RIG‐I/MDA5–MAVS signaling to elicit type I interferon responses, thereby promoting antigen ...
Xing Huang, Shaoqing Yu, Wenjie Wei, Wen Tao, Tianwei Cai, Lequan Wen, Jiali Ye, Chi Zhang, Huayi Feng, Senming Cao, Baojun Wang, Xin Ma, Yan Huang, Xu Zhang   +13 more
wiley   +1 more source

Spatially resolved whole-transcriptomic profiling of EGFR-mutated lung adenocarcinomas stratified by PD-L1 expression. [PDF]

Cell Oncol (Dordr)
Yu C, Shi C, Zhou H, Li N, Ma R, Liu S, Tang Z, Zhang X, Lei Z, Qin H.   +9 more
europepmc   +1 more source

CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target

Advanced Science, EarlyView.
This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang, Huijie Bian, Zhi‐Nan Chen   +2 more
wiley   +1 more source