Results 51 to 60 of about 276,897 (341)

Regulation of PD-L1 expression in a high-grade invasive human oral squamous cell carcinoma microenvironment [PDF]

, 2016
Blockade of the programmed-death 1 receptor (PD-1)/programmed-death ligand (PD-L1) pathway efficiently reduces tumour growth and improves survival. Durable tumour regression with blockade of the PD-1/PD-L1 checkpoint has been demonstrated in recent ...
Bou-Gharios, George, Hirai, Mariko, Kato, Koroku, Kawashiri, Shuichi, Kitahara, Hiroko, Kobayashi, Yutaka, Nakamura, Hiroyuki   +6 more
core   +1 more source

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

Interferon‑γ induced PD‑L1 expression and soluble PD‑L1 production in gastric cancer

Oncology Letters, 2020
Programmed death-ligand 1 (PD-L1) plays an essential role in tumor cell escape from anti-tumor immunity in various types of cancer, including gastric cancer (GC). The present study investigated the intracellular and membrane-bound expression of PD-L1 in the GC cell lines MKN1, MKN74, KATO III and OCUM-1. Furthermore, soluble PD-L1 (sPD-L1) level in the
Imai, Yushi, Chiba, Tetsuhiro, Kondo, Takayuki, Kanzaki, Hiroaki, Kanayama, Kengo, Ao, Junjie, Kojima, Ryuta, Kusakabe, Yuko, Nakamura, Masato, Saito, Tomoko, Nakagawa, Ryo, Suzuki, Eiichiro, Nakamoto, Shingo, Muroyama, Ryosuke, Tawada, Akinobu, Matsumura, Tomoaki, Nakagawa, Tomoo, Kato, Jun, Kotani, Ai, Matsubara, Hisahiro, Kato, Naoya   +20 more
openaire   +3 more sources

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Prognostic perspectives of PD-L1 combined with tumor-infiltrating lymphocytes, Epstein-Barr virus, and microsatellite instability in gastric carcinomas

Diagnostic Pathology, 2020
Background The prognostic potential of PD-L1 is currently unclear in gastric carcinomas, although the immune checkpoint PD-1/PD-L1 inhibitors have produced promising results in clinical trials.
Euno Choi, Mee Soo Chang, Sun-ju Byeon, Heejin Jin, Kyeong Cheon Jung, Haeryoung Kim, Kook Lae Lee, Won Kim, Jin Hyun Park, Ki Hwan Kim, Jin-Soo Kim, In Sil Choi, Dong-Seok Han, Hye Seong Ahn, Seung Chul Heo   +14 more
doaj   +1 more source

STING mediates nuclear PD-L1 targeting-induced senescence in cancer cells

Cell Death and Disease, 2022
Immune checkpoint molecule programmed death-ligand 1 (PD-L1) is overexpressed in cancer cells and imparts resistance to cancer therapy. Although membrane PD-L1 has been targeted for cancer immune therapy, nuclear PD-L1 was reported to confer cancer ...
Je-Jung Lee, So Young Kim, Songhee H. Kim, Seoyeon Choi, Bin Lee, Jeon-Soo Shin   +5 more
doaj   +1 more source

Immune-derived PD-L1 gene expression defines a subgroup of stage II/III colorectal cancer patients with favorable prognosis that may be harmed by adjuvant chemotherapy [PDF]

, 2016
A recent phase II study of patients with metastatic colorectal carcinoma showed that mismatch repair gene status was predictive of clinical response to PD-1–targeting immune checkpoint blockade.
Allen, Wendy L., Coleman, Helen G., Dunne, Philip D., Johnston, Patrick G., Lawler, Mark, Longley, Daniel B., Loughrey, Maurice, McArt, Darragh G., McDade, Simon, O'Reilly, Paul G., Salto-Tellez, Manuel, Van Schaeybroeck, Sandra   +11 more
core   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory. [PDF]

, 2019
PD-L1 on the surface of tumor cells binds its receptor PD-1 on effector T cells, thereby suppressing their activity. Antibody blockade of PD-L1 can activate an anti-tumor immune response leading to durable remissions in a subset of cancer patients ...
Belair, Cassandra D, Blelloch, Robert, Chang, Anthony, Chu, Brandon, Fong, Lawrence, Fu, Qi, Hu, Tianyi, Lang, Ursula E, Montabana, Elizabeth, Pai, Chien-Chun, Poggio, Mauro   +10 more
core  

COX-2 expression positively correlates with PD-L1 expression in human melanoma cells. [PDF]

, 2017
BACKGROUND: The resistance to PD-1/PD-L1 inhibitors for the treatment of melanoma have prompted investigators to implement novel clinical trials which combine immunotherapy with different treatment modalities. Moreover is also important to investigate
Anniciello, Anna Maria, Ascierto, Paolo Antonio, Botti, Gerardo, Cantile, Monica, Caracò, Corrado, Cerrone, Margherita, Cirino, Giuseppe, Colombino, Maria, D’Alterio, Crescenzo, Fratangelo, Federica, Ianaro, Angela, Liguori, Giuseppina, Palmieri, Giuseppe, Pepe, Stefano, Sabbatino, Francesco, Scala, Stefania, Scognamiglio, Giosuè, Trimarco, Chiara   +17 more
core   +2 more sources