Results 241 to 250 of about 54,977 (304)

High‐Content CRISPR Screening: Methods and Applications

MedComm, Volume 7, Issue 9, September 2026.
High‐content CRISPR screening represents a paradigm shift in functional genomics, moving beyond traditional survival‐based readouts to enable multidimensional mapping of genotype–phenotype relationships. This review systematically outlines the methodological evolution of this approach, detailing advances in perturbation modalities, delivery systems ...
Yike Zhang, Yimeng Zhang, Xudong Tang, Xinyu Deng, Yitian Zhou, Yanfeng Wu, Jianhua Luo   +6 more
wiley   +1 more source

Targeted Therapy in Pancreatic Ductal Adenocarcinoma: Current Advances and Challenges. [PDF]

Curr Oncol
Habib R, Arnold E, Obi T, Vizeacoumar FJ, Ahmed S.   +4 more
europepmc   +1 more source

Microbial Signals in Cancer: Dissecting Host–Microbiota–Tumor Interactions and Potential Therapeutic Strategy

MedComm, Volume 7, Issue 9, September 2026.
Microbial signals from gut and tumor‐resident bacteria, fungi, viruses, and bacteriophages reshape immune and metabolic networks within the tumor microenvironment, thereby influencing cancer progression, treatment response. Therapeutic modulations, including dietary interventions, probiotics, antibiotics, fecal microbiota transplantation, engineered ...
Juan Lu, Mengjuan Xuan, Liang Yu, Zhongyang Xie, Qingfei Chu, Shihui Wei, Tuokai Wang, Chen Xue, Lanjuan Li   +8 more
wiley   +1 more source

Adjuvant Therapy in Pancreatic Ductal Adenocarcinoma-Past, Present, and Future. [PDF]

Cancers (Basel)
Tran A, Jain T, Fei N, Dudeja V.
europepmc   +1 more source

Cancer Neuroscience: From Local Neuro–Immune Microenvironments to Systemic Brain–Body Circuitry

MedComm, Volume 7, Issue 9, September 2026.
This review outlines the cancer neuroscience paradigm, spanning systemic brain–body circuitry and local neuro–immune–tumor microenvironments. We discuss how tumors promote axonogenesis and pseudo‐synapse formation, and how sensory neuropeptides, such as CGRP, contribute to CD8+ T‐cell exhaustion.
Mingxuan Xie, Yu Zhao, Xinruo Xing, Yuqiang Liu, Jungang Zhao, Maojin Yao, Jun Tang, Jianzhu Zhao   +7 more
wiley   +1 more source

Exploratory Multi-Platform Bioinformatic Analysis of MEAK7 and Its Molecular, Survival, and Immune Associations in Pancreatic Ductal Adenocarcinoma. [PDF]

Int J Mol Sci
Uyaner Kan M, Ayan D.
europepmc   +1 more source

Oxidative and Antioxidant Systems in Ferroptosis of Cancer: Mechanisms, Regulations, and Therapeutic Targeting

MedComm – Oncology, Volume 5, Issue 3, September 2026.
Ferroptosis is governed by the balance between reactive oxygen species (ROS)‐driven lipid peroxidation and a multi‐tiered antioxidant network. ROS sources include mitochondrial electron transport chain, voltage‐dependent anion channels, NADPH oxidases, and endoplasmic reticulum‐resident oxidoreductases, while antioxidant defenses span the primary GSH ...
Deepak K, Pritam Kumar Roy, Maniklal Shee, Budhaditya Mukherjee, Aoife Ward Gahlawat, Mahitosh Mandal   +5 more
wiley   +1 more source

Clinical Utility of Circulating Tumor DNA Analysis in Pancreatic Ductal Adenocarcinoma. [PDF]

Clin Med Insights Oncol
Lee M, Lee JY, Kang IH, Sung CO, Jun HR, Hwang DW, Jun E, Chun SM.   +7 more
europepmc   +1 more source

DNA Hypomethylation in Pancreatic Cancer Tissues Before Treatment, Defined by KRAS -mutated Circulating Tumor DNA, is Associated With Poor Prognosis. [PDF]

Pancreas
Watanabe F, Suzuki K, Hasebe R, Mizusawa Y, Aizawa H, Abe I, Endo Y, Ichida K, Inoue K, Noda H, Rikiyama T.   +10 more
europepmc   +1 more source

Cyclooxygenases in pancreatic ductal adenocarcinoma: are they inflammatory catalysts for tumor growth. [PDF]

Front Oncol
Orhan A, Orhan T, Raskov H, Gögenur I.
europepmc   +1 more source