Results 221 to 230 of about 54,977 (304)

Claudin 18.2 Positivity Thresholds and Candidate Populations for Targeted Therapy in Pancreatic Ductal Adenocarcinoma: A Real-World Retrospective Cohort. [PDF]

Cancers (Basel)
Akgüner G, Haznedaroğlu Benlioğlu E, Yıldırım ÖA, Güleşen Aİ, Günel B, Arıkök AT, Çakmak Öksüzoğlu ÖB, Yücel KB.   +7 more
europepmc   +1 more source

Cardiovascular–Kidney–Metabolic Syndrome Severity and Risk of Pancreatic Cancer in a Large Prospective Cohort

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 6, September 2026.
ABSTRACT Aims Pancreatic cancer remains one of the most lethal malignancies due to late diagnosis and limited opportunities for prevention. Cardiovascular–kidney–metabolic (CKM) syndrome reflects the cumulative burden of metabolic, renal, and cardiovascular dysfunction, but its association with pancreatic cancer risk has not been well established.
Munseok Choi, Seok‐Jae Heo, Yu‐Jin Kwon, Chang Moo Kang   +3 more
wiley   +1 more source

Chemotherapy-induced CAF-associated stromal remodeling in a humanized stroma pancreatic ductal adenocarcinoma organoid xenograft model: a comparison between GP and GS. [PDF]

Hum Cell
Furihata K, Iwashita W, Kurabayashi A, Furihata M, Uchida K, Taniuchi K.   +5 more
europepmc   +1 more source

Autophagy inhibition in pancreatic cancer: hope or hype? [PDF]

Autophagy Rep
Guilbaud E, Cukierman E, Astsaturov I, Galluzzi L.   +3 more
europepmc   +1 more source

Transcriptome‐Based Classification of Resected Pancreatic Ductal Adenocarcinoma Enhances Prognostic Modelling Accuracy of Overall Survival Following Adjuvant Treatment

International Journal of Cancer, Volume 159, Issue 5, Page 1322-1336, 1 September 2026.
Outcomes after resection of pancreatic ductal adenocarcinoma remain highly variable, and existing prognostic models lack sufficient accuracy. Here, the authors aimed to improve survival prediction by integrating transcriptome‐based subtyping into a validated clinical model and applying it to a multicenter real‐world cohort of fresh‐frozen resection ...
Marjolein F. Lansbergen, Vincent R. Lanting, Paul Manoukian, Marc G. Besselink, Geert Kazemier, Ignace H. J. T. de Hingh, Mike S. L. Liem, Casper H. J. van Eijck, Erwin van der Harst, Vincent E. de Meijer, Ronald M. van Dam, Martijn W. J. Stommel, Jan Koster, Michael W. T. Tanck, Arantza Fariña Sarasqueta, Joanne Verheij, Frederike Dijk, Johanna W. Wilmink, Maarten F. Bijlsma, Hanneke W. M. van Laarhoven, for the Dutch Pancreatic Cancer Group   +20 more
wiley   +1 more source

Blocking L-carnitine synthesis by meldonium prolongs the survival in mice with pancreatic cancer. [PDF]

iScience
Sano M, Ijichi H, Tabata S, Hirayama A, Shimma S, Masugi Y, Ichimaru Y, Kim J, Kimura G, Miyabayashi K, Takahashi R, Hatakeyama H, Suzuki T, Masamune A, Soga T, Fujishiro M.   +15 more
europepmc   +1 more source

Bovine Colostrum‐Derived Extracellular Vesicles Impair Cancer Cell Proliferation Through Transcriptional Dysregulation

Journal of Extracellular Vesicles, Volume 15, Issue 9, September 2026.
ABSTRACT Milk‐derived extracellular vesicles (EVs) are a promising source of molecules with therapeutic potential. Bovine colostrum is particularly enriched in EVs, which carry cargo of proteins involved in immune regulation, development and cellular signalling.
Claudia Betsabé Huesa‐Carballo, Bruno Puga, Susana Bravo, Manuel Rodríguez‐Pérez, Yessica Domínguez‐Novoa, Julio Iglesias‐García, Brígida Hermida, Isolina Raña, María Teresa Antelo, Rafael López‐López, Miguel Abal, Jorge Barbazán   +11 more
wiley   +1 more source

A Novel Index Consisting of Age, CA19-9, and Methylated Somatostatin Is Useful for Diagnosing Early Pancreatic Cancer. [PDF]

Cancer Med
Tabara S, Suehiro Y, Suehiro H, Shinagawa U, Hamamoto K, Tsuyama T, Shinoda S, Suenaga S, Kunimune Y, Fujii I, Suzuki C, Higaki S, Takami T, Yamasaki T.   +13 more
europepmc   +1 more source

Mitochondrial CLPP in Health and Disease: Mechanisms, Therapeutic Duality and Emerging Opportunities

Journal of Inherited Metabolic Disease, Volume 49, Issue 5, September 2026.
The graphical abstract illustrates the context‐dependent therapeutic modulation of CLPP. Pharmacological CLPP activation has reached clinical application in cancer (black arrow), whereas reduced CLPP activity has shown beneficial effects experimentally in models of primary mitochondrial disease and metabolic syndrome, as well as cancer (grey arrows ...
Lea Isermann, Aleksandra Trifunovic
wiley   +1 more source

Adjuvant FOLFIRINOX versus S-1 monotherapy for resected PDAC: retrospective real-world data. [PDF]

Ther Adv Med Oncol
Tang H, Li Z, You T, Ying J, Cheng Y, Bai C, Wang Y.   +6 more
europepmc   +1 more source