Results 201 to 210 of about 54,977 (304)

Microarray chip to fabricate 3D PDAC heterospheroids with architectural organization towards tumor invasion and chemoresistance study. [PDF]

Microsyst Nanoeng
Wei X, Lan X, Pan Y, Wang L, Chen K, Xu M.   +5 more
europepmc   +1 more source

Die Resistenzmechanismen gegen die Deletion von Pdk1 in PDAC entdecken

Pancreatic ductal adenocarcinoma (PDAC) poses a significant global health challenge. The novel dual recombinase mouse model identifies the crucial role of Pdk1 in PDAC carcinogenesis.
Ondrejková, Katarína
core  

Natural History of Recurrent Acute Pancreatitis: Implications for Interventional Trial Design

Alimentary Pharmacology &Therapeutics, Volume 64, Issue 7, Page 976-984, October 2026.
In this nationwide cohort of 6894 patients with recurrent acute pancreatitis, recurrence risk increased progressively with each episode and occurred most frequently within the first year. Successive episodes were separated by shorter intervals, indicating an accelerating disease course and highlighting the importance of early preventive interventions ...
Søren S. Olesen, Niels Henrik Bruun, Line Davidsen, Srdan Novovic, Stig B. Laursen, Enrique de‐Madaria, Dhiraj Yadav, Asbjørn M. Drewes   +7 more
wiley   +1 more source

Rethinking PDAC: from immunological silence to therapeutic opportunity. [PDF]

Front Immunol
Kali SK, Ramesh RPG, Alam A, Fernandez-Cabezudo MJ, Al-Awadhi AM, Kishore U, Al-Ramadi BK.   +6 more
europepmc   +1 more source

miRNA484 and miRNA335-5p as Potential Diagnostic Biomarkers for CA19-9-Negative Pancreatic Ductal Adenocarcinoma. [PDF]

Biomolecules
Prado NO, Marin AM, Zem C, de Marchi M, Araújo DD, Alves MJF, Uno M, Chammas R, Zanette DL, Aoki MN.   +9 more
europepmc   +1 more source

KRAS-driven cytokine-metabolic crosstalk shapes immune exclusion in pancreatic ductal adenocarcinoma. [PDF]

Front Genet
Huang C, Mai G, Li Y, Liu H, Huang W.
europepmc   +1 more source

Heparan Sulfate Proteoglycans in Pancreatic Ductal Adenocarcinoma (PDAC)

We have previously identified a heparan sulfate proteoglycan (HSPG), Syndecan-1 (SDC1), as a key effector for pancreatic ductal adenocarcinoma (PDAC) progression whose surface expression is driven by KRAS*.
Theardy, Madelaine
core  

Stiffness‐Activated Stellate Cells Drive Pancreatic Cancer Liver Colonization via GMFG‐TNS4 Signaling

Advanced Science, Volume 13, Issue 51, 14 September 2026.
Fibrotic liver stiffness activates hepatic stellate cells through Piezo1‐dependent calcium influx and ER stress, promoting EV‐associated GMFG release. Delivered GMFG engages TNS4 in pancreatic cancer cells, triggering FAK/AKT signaling, adhesion, and fatty acid synthesis.
Biwen Zhu, Jian Wan, Xue Zhang, Jiashuai Yan, Xi Chen, Xiaoqi Guan, Qianqian Ren, Tao Yang, Di Wu, Qingsong Guo, Yibing Guo, Yuhua Lu   +11 more
wiley   +1 more source

[¹⁷⁷Lu]Lu-AKIR001 for CD44v6-Positive Pancreatic Cancer: Preclinical Efficacy and Combination Strategies. [PDF]

J Nucl Med
Gustafsson A, Svedberg H, Rinne SS, Bertilsson F, Selvaraju RK, Lundgren Mortensen AC, Lindskog C, Nestor M.   +7 more
europepmc   +1 more source

Pancreatic Atrophy: A Narrative Review and Surgical Interpretation

Annals of Gastroenterological Surgery, Volume 10, Issue 5, Page 1419-1427, September 2026.
Pancreatic parenchymal atrophy pattern and intraoperative margin assessment guide surgical strategy. ABSTRACT Despite recent advances in multimodal management, pancreatic ductal adenocarcinoma remains a fatal malignancy. Early detection of indirect findings of pancreatic ductal adenocarcinoma is essential to improve treatment outcomes, drawing ...
Rika Fujino, Ken‐ichi Okada, Yohei Masugi, Eisuke Iwasaki, Masaki Mori   +4 more
wiley   +1 more source