Results 41 to 50 of about 85,787 (336)

Single-cell analysis of patient-derived PDAC organoids reveals cell state heterogeneity and a conserved developmental hierarchy

Nature Communications, 2020
Pancreatic ductal adenocarcinoma (PDAC) is projected to be the second leading cause of cancer mortality by 2030. Bulk transcriptomic analyses have distinguished ‘classical’ from ‘basal-like’ tumors with more aggressive clinical behavior.
T. Krieger, Solange LeBlanc-Soto, Julia Jabs, F. Ten, Naveed Ishaque, K. Jechow, Anamika Giri, R. Eils, O. Strobel, C. Conrad   +9 more
semanticscholar   +1 more source

Upregulated MicroRNA-483-3p is an Early Event in Pancreatic Ductal Adenocarcinoma (PDAC) and as a Powerful Liquid Biopsy Biomarker in PDAC

OncoTargets and Therapy, 2021
Background There is an urgent need for the development of effective noninvasive biomarkers for early pancreatic cancer diagnosis. MicroRNAs (miRNAs) are promising candidates that can be identified in peripheral blood and can act as “liquid biopsy ...
H. Shao, Yue Zhang, Jie Yan, Xinchao Ban, Xiaojie Fan, X. Chang, Zhaohui Lu, Yan Wu, L. Zong, S. Mo, Shuangni Yu, Jie Chen   +11 more
semanticscholar   +1 more source

Targeting ROCK activity to disrupt and prime pancreatic cancer for chemotherapy [PDF]

, 2017
Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease; the identification of novel targets and development of effective treatment strategies are urgently needed to improve patient outcomes.
Olson, Michael F., Pajic, Marina, Rath, Nicola, Timpson, Paul, Vennin, Claire   +4 more
core   +1 more source

NK cells in pancreatic cancer demonstrate impaired cytotoxicity and a regulatory IL-10 phenotype

OncoImmunology, 2020
Pancreatic ductal adenocarcinoma (PDAC) is one of the most common tumor subtypes and remains associated with very poor survival. T cell infiltration into tumor tissue is associated with improved clinical outcome but little is known regarding the ...
Francesca Marcon, Jianmin Zuo, Hayden Pearce, Samantha Nicol, Sandra Margielewska-Davies, Mustafa Farhat, Brinder Mahon, Gary Middleton, Rachel Brown, Keith J. Roberts, Paul Moss   +10 more
doaj   +1 more source

Ultrasound- and Microbubble-Assisted Gemcitabine Delivery to Pancreatic Cancer Cells

Pharmaceutics, 2020
Pancreatic ductal adenocarcinoma (PDAC) is a major cause of cancer death worldwide. Poor drug delivery to tumours is thought to limit chemotherapeutic treatment efficacy. Sonoporation combines ultrasound (US) and microbubbles to increase the permeability
Tormod Bjånes, Spiros Kotopoulis, Elisa Thodesen Murvold, Tina Kamčeva, Bjørn Tore Gjertsen, Odd Helge Gilja, Jan Schjøtt, Bettina Riedel, Emmet McCormack   +8 more
doaj   +1 more source

An environmentally benign antimicrobial nanoparticle based on a silver-infused lignin core [PDF]

, 2015
Silver nanoparticles have antibacterial properties, but their use has been a cause for concern because they persist in the environment. Here, we show that lignin nanoparticles infused with silver ions and coated with a cationic polyelectrolyte layer form
A Duval, A Kumar, A Panáček, A Panáček, A Verma, AE Nel, Alexander P. Richter, AM El Badawy, Amy Wang, Bhuvnesh Bharti, C Frangville, C Ge, C Levard, C Wandrey, E Jeong, Elaine A. Cohen Hubal, G Marchant, GA Sotiriou, H Harmita, H Lara, HA Wege, I Sondi, J Dobias, J Fabrega, Joseph S. Brown, JR Morones, K Lundquist, K Poole, Keith Houck, L Petridis, M Ahamed, M Lundqvist, M Norgren, M Rai, MP Monopoli, O Choi, Orlin D. Velev, P Anastas, P Gélinas, P Raveendran, QL Feng, R Justo-Hanani, R Kavlock, S Kim, S Langsrud, S Tan, Simeon D. Stoyanov, SL Chinnapongse, ST Stern, Sumit Gangwal, T Silva, T Walser, TDH Bugg, Vesselin N. Paunov, VK Sharma, VK Sharma, X Guo, Y Matsumura, Z Xiu   +58 more
core   +2 more sources

Renalase is a novel tissue and serological biomarker in pancreatic ductal adenocarcinoma.

PLoS ONE, 2021
Dysregulated expression of the secretory protein renalase can promote pancreatic ductal adenocarcinoma (PDAC) growth in animal models. We characterized renalase expression in premalignant and malignant PDAC tissue and investigated whether plasma renalase
Yasheen Gao, Melinda Wang, Xiaojia Guo, Joanna Hu, Tian-Min Chen, Sade M B Finn, Jill Lacy, John W Kunstman, Charles H Cha, Melena D Bellin, Marie E Robert, Gary V Desir, Fred S Gorelick   +12 more
doaj   +1 more source

Cell Lineage Infidelity in PDAC Progression and Therapy Resistance

Frontiers in Cell and Developmental Biology, 2021
Infidelity to cell fate occurs when differentiated cells lose their original identity and either revert to a more multipotent state or transdifferentiate into a different cell type, either within the same embryonic lineage or in an entirely different one.
A. Malinova, L. Veghini, F. Real, V. Corbo   +3 more
semanticscholar   +1 more source

MicroRNA co-expression networks exhibit increased complexity in pancreatic ductal compared to Vater’s papilla adenocarcinoma [PDF]

, 2017
iRNA expression abnormalities in adenocarcinoma arising from pancreatic ductal system (PDAC) and Vater’s papilla (PVAC) could be associated with distinctive pathologic features and clinical cancer behaviours.
Andriulli, Angelo, Biagini, Tommaso, Capocefalo, Daniele, Carella, Massimo, Copetti, Massimiliano, De Bonis, Antonio, Di Sebastiano, Pierluigi, Francesco Di Mola, Fabio, Fusilli, Caterina, Maiello, Evaristo, Mastrodonato, Nicola, Mazza, Tommaso, Pazienza, Valerio, Piepoli, Ada, Tavano, Francesca   +14 more
core   +1 more source

WDR79 promotes aerobic glycolysis of pancreatic ductal adenocarcinoma (PDAC) by the suppression of SIRT4

Open Medicine, 2023
Pancreatic cancer (PC) is an aggressive malignant disease. Pancreatic ductal adenocarcinoma (PDAC) is a main type of PDAC. The inhibition of aerobic glycolysis in PC cells is one of the approaches to treat PDAC.
Yin Wenke, Song Xiaoyan, Xiang Yue
doaj   +1 more source