Results 51 to 60 of about 49,553 (292)
Fibroblasts shape PDAC architecture [PDF]
Nature Reviews Cancer, 2019 Ligorio, Sil et al. used a combination of single-cell RNA and proteomic techniques in both model systems and human pancreatic ductal adenocarcinomas (PDACs) to better understand the interplay between cancer cells and fibroblasts, and the implications of this for PDAC progression.
openaire +2 more sources
DTI measurements of PDAC patients.
, 2014 Mean values ± SD of λ1, λ2, λ3, ADC and FA in nine PDAC patients. The results were obtained by analyzing ROIs of PDAC and pancreatic tissue distal to the tumor that appeared normal, using b = 0,500 s/mm2 and b = 100,500 s/mm2.
Sara Apter (680094) +10 more
core +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
IGF1R and CA9 expression in PDAC.
, 2016 (A) Representative staining of CA9 cells quantified on a scoring system of 0–3 according to staining intensity (original magnification ×200). CA9 was mainly expressed in the cell membrane of PDAC cells.
Tamami Morisaki (656222) +9 more
core +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Identification of Potential Biomarkers in PDAC
, 2014 Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer deaths in both men and women in the United States, with a 5-year survival rate of approximately 6%.
Whittlesey, Rebecca
core +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Clinical features and prognostic impact of asymptomatic pancreatic cancer
Scientific Reports, 2022 Pancreatic ductal adenocarcinoma (PDAC) is highly lethal, and early diagnosis is challenging. Because patients who present with symptoms generally have advanced-stage diseases, analysis of asymptomatic PDAC provides invaluable information for developing ...
Tetsuya Takikawa +13 more
doaj +1 more source
dpeerlab/pdac-progression: April 2023 Update
, 2023 No description ...
Cassandra Burdziak
core +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source