Results 41 to 50 of about 49,553 (292)

Increased SPARC expression is associated with neoadjuvant therapy in resectable pancreatic ductal adenocarcinoma

Practical Laboratory Medicine, 2020
Secreted Protein Acid and Rich in Cysteine (SPARC) is an extracellular glycoprotein secreted by fibroblasts and osteoblasts in normal tissues. SPARC overexpression occurs in multiple tumors including pancreatic ductal adenocarcinoma (PDAC) and may ...
Christopher Hartley, Daniel Rowan, Xiuxu Chen, Luisa Gomez-Arellano, Anna Marie West, Kiyoko Oshima, Alexander Craig Mackinnon   +6 more
doaj   +1 more source

Integrated analysis revealed hypoxia signatures and LDHA related to tumor cell dedifferentiation and unfavorable prognosis in pancreatic adenocarcinoma

Translational Oncology, 2023
Pancreatic ductal adenocarcinoma (PDAC) is a highly heterogeneous cancer with limited understanding of its classification and tumor microenvironment.
Mingwei Dong, Rong Tang, Wei Wang, Jin Xu, Jiang Liu, Chen Liang, Jie Hua, Qingcai Meng, Xianjun Yu, Bo Zhang, Si Shi   +10 more
doaj   +1 more source

Noninvasive detection of pancreatic ductal adenocarcinoma using the methylation signature of circulating tumour DNA

BMC Medicine, 2022
Background Pancreatic ductal adenocarcinoma (PDAC) has the lowest overall survival rate primarily due to the late onset of symptoms and rapid progression. Reliable and accurate tests for early detection are lacking. We aimed to develop a noninvasive test
Huanwen Wu, Shiwei Guo, Xiaoding Liu, Yatong Li, Zhixi Su, Qiye He, Xiaoqian Liu, Zhiwen Zhang, Lianyuan Yu, Xiaohan Shi, Suizhi Gao, Huan Wang, Yaqi Pan, Chengcheng Ma, Rui Liu, Menghua Dai, Gang Jin, Zhiyong Liang   +17 more
doaj   +1 more source

Combination of serum human satellite RNA and miR-21-5p levels as a biomarker for pancreatic cancer

iScience, 2023
Summary: Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis due to the difficulty of its diagnosis. Because human satellite II (HSATII) RNA, a satellite repeat RNA, is highly and specifically expressed in human PDAC, the serum HSATII RNA level ...
Takahiro Seimiya, Tatsunori Suzuki, Takuma Iwata, Takahiro Kishikawa, Kazuma Sekiba, Chikako Shibata, Kazunaga Ishigaki, Hiroaki Fujiwara, Hiroki Oyama, Sachiko Kanai, Tatsuya Sato, Yousuke Nakai, Rei Ishibashi, Masaru Moriyama, Ryo Nakagawa, Hideaki Ijichi, Motoyuki Otsuka, Kazuhiko Koike   +17 more
doaj   +1 more source

Autophagy is required for PDAC glutamine metabolism [PDF]

Scientific Reports, 2016
AbstractMacroautophagy (autophagy) is believed to maintain energy homeostasis by degrading unnecessary cellular components and molecules. Its implication in regulating cancer metabolism recently started to be uncovered. However, the precise roles of autophagy in cancer metabolism are still unclear.
Seo, Ju-Won, Choi, Jungwon, Lee, So-Yeon, Sung, Suhyun, Yoo, Hyun Ju, Kang, Min-Ji, Cheong, Heesun, Son, Jaekyoung   +7 more
openaire   +3 more sources

Enhanced release of ciliary extracellular vesicles suppresses cell migration and promotes cell aggregation

Cell Structure and Function
A primary cilium is a hair-like organelle that protrudes from the cell surface in many cell types. Growing evidence indicates that extracellular vesicles are released from primary cilia, and research is increasingly focused on defining the functions of ...
Tetsuhiro Hara, Ryota Nakazato, Kenji Shirakawa, Faryal Ijaz, Kenichiro Uemura, Shinya Takahashi, Koji Ikegami   +6 more
doaj   +1 more source

Microbiome in pancreatic cancer – What is new in 2024? [PDF]

Microbiota in Health and Disease
Despite great efforts to improve understanding and treatment of pancreatic cancer, mainly pancreatic ductal adenocarcinoma (PDAC), the outcome of this malignant disease today is still very poor.
E. Hohmann, C. Ammer-Herrmenau, C. Schulz, S. Sirtl   +3 more
doaj   +1 more source

Cationic amphiphilic drugs as potential anticancer therapy for PDAC

, 2022
Pancreatic ductal adenocarcinoma (PDAC) is the sixth leading cause of death worldwide. PDAC carries a 5-y survival of less than 10%, as it is often diagnosed at a late stage and is widely refractory to available therapies.
Selaković Života, Pavić Aleksandar, Šolaja Bogdan, Živanović Marija, Grahovac Jelena, Srdić-Rajić Tatjana, Selaković Milica   +6 more
core   +1 more source

Loss of FGFR4 promotes the malignant phenotype in pancreas ductal adenocarcinoma

, 2023
openL’adenocarcinoma duttale del pancreas (PDAC) è una patologia di particolare interesse nel campo della ricerca oncologica vista l’elevata aggressività e mortalità, infatti presenta un tasso di sopravvivenza a 5 anni minore del 10%, con una mediana ...
FLORA, CARLO ALBERTO
core  

Blocking circ_0013912 Suppressed Cell Growth, Migration and Invasion of Pancreatic Ductal Adenocarcinoma Cells in vitro and in vivo Partially Through Sponging miR-7-5p

Cancer Management and Research, 2020
Weisheng Guo,1 Lin Zhao,1 Guangya Wei,1 Peng Liu,1 Yu Zhang,1 Liran Fu2 1Department of Hepatobiliary Surgery, Henan Province Hospital of Traditional Chinese Medicine, The Second Affiliated Hospital of Henan University of Traditional Chinese Medicine ...
Guo W, Zhao L, Wei G, Liu P, Zhang Y, Fu L   +5 more
doaj