Results 41 to 50 of about 54,977 (304)

Early Diagnosis of Pancreatic Ductal Adenocarcinoma by Combining Relative Expression Orderings With Machine-Learning Method

Frontiers in Cell and Developmental Biology, 2020
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and lethal cancer deeply affecting human health. Diagnosing early-stage PDAC is the key point to PDAC patients’ survival. However, the biomarkers for diagnosing early PDAC are inexact in most cases.
Zi-Mei Zhang, Jia-Shu Wang, Hasan Zulfiqar, Hao Lv, Fu-Ying Dao, Hao Lin   +5 more
doaj   +1 more source

Fibroblasts shape PDAC architecture [PDF]

Nature Reviews Cancer, 2019
Ligorio, Sil et al. used a combination of single-cell RNA and proteomic techniques in both model systems and human pancreatic ductal adenocarcinomas (PDACs) to better understand the interplay between cancer cells and fibroblasts, and the implications of this for PDAC progression.
openaire   +2 more sources

Increased SPARC expression is associated with neoadjuvant therapy in resectable pancreatic ductal adenocarcinoma

Practical Laboratory Medicine, 2020
Secreted Protein Acid and Rich in Cysteine (SPARC) is an extracellular glycoprotein secreted by fibroblasts and osteoblasts in normal tissues. SPARC overexpression occurs in multiple tumors including pancreatic ductal adenocarcinoma (PDAC) and may ...
Christopher Hartley, Daniel Rowan, Xiuxu Chen, Luisa Gomez-Arellano, Anna Marie West, Kiyoko Oshima, Alexander Craig Mackinnon   +6 more
doaj   +1 more source

Noninvasive detection of pancreatic ductal adenocarcinoma using the methylation signature of circulating tumour DNA

BMC Medicine, 2022
Background Pancreatic ductal adenocarcinoma (PDAC) has the lowest overall survival rate primarily due to the late onset of symptoms and rapid progression. Reliable and accurate tests for early detection are lacking. We aimed to develop a noninvasive test
Huanwen Wu, Shiwei Guo, Xiaoding Liu, Yatong Li, Zhixi Su, Qiye He, Xiaoqian Liu, Zhiwen Zhang, Lianyuan Yu, Xiaohan Shi, Suizhi Gao, Huan Wang, Yaqi Pan, Chengcheng Ma, Rui Liu, Menghua Dai, Gang Jin, Zhiyong Liang   +17 more
doaj   +1 more source

Hypomethylation of GNA15 Promotes Pancreatic Ductal Adenocarcinoma Progression and Macrophage M2 Polarization via STAT3-CXCL8 Axis. [PDF]

Adv Sci (Weinh)
A schematic model summarizing GNA15's mechanism in mediating macrophage M2 polarization and Gemcitabine resistance. ABSTRACT The complexity of pancreatic ductal adenocarcinoma (PDAC) progression, coupled with the lack of effective immunotherapy, underscores the imperative to deepen our understanding of its mechanisms and identify suitable immune ...
Guo W, Qian Z, Wang L, Xu W, Weng Y, Jiang K, Ye Z, Xu J, Song G.   +8 more
europepmc   +2 more sources

Loss of FGFR4 promotes the malignant phenotype in pancreas ductal adenocarcinoma

, 2023
openL’adenocarcinoma duttale del pancreas (PDAC) è una patologia di particolare interesse nel campo della ricerca oncologica vista l’elevata aggressività e mortalità, infatti presenta un tasso di sopravvivenza a 5 anni minore del 10%, con una mediana ...
FLORA, CARLO ALBERTO
core  

PTEN and MIR-21 Expression in IPMN and PDAC [PDF]

, 2012
Context The prognosis of invasive IPMN is better than for PDAC and many authors believe that IPMNs have distinct genetic and biological characteristics underlying this different clinical behavior.
Funel, Niccola, Denaro, Maria, Boggi, Ugo, Pollina, Luca E, Perrone, Vittorio, Alvino, Alessandra, Campani, Daniela, Giovannetti, Elisa, De Lio, Nelide, Caniglia, Fabio, Botta, Lucia   +10 more
core   +1 more source

Cationic amphiphilic drugs as potential anticancer therapy for PDAC

, 2022
Pancreatic ductal adenocarcinoma (PDAC) is the sixth leading cause of death worldwide. PDAC carries a 5-y survival of less than 10%, as it is often diagnosed at a late stage and is widely refractory to available therapies.
Selaković Života, Pavić Aleksandar, Šolaja Bogdan, Živanović Marija, Grahovac Jelena, Srdić-Rajić Tatjana, Selaković Milica   +6 more
core   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

DTI measurements of PDAC patients.

, 2014
Mean values ± SD of λ1, λ2, λ3, ADC and FA in nine PDAC patients. The results were obtained by analyzing ROIs of PDAC and pancreatic tissue distal to the tumor that appeared normal, using b = 0,500 s/mm2 and b = 100,500 s/mm2.
Sara Apter (680094), Noam Nissan (680091), Yuri Goldes (680098), Edna Furman-Haran (680093), Arie Ariche (680096), Yael Inbar (680095), Dov Grobgeld (680100), Hadassa Degani (680101), Talia Golan (680092), Barak Bar-Zakay (680097), Michael Schvimer (680099)   +10 more
core   +1 more source