Results 41 to 50 of about 2,300 (225)

Experimental Study on Force of PDC Cutter Breaking Rock

open access: yesProcedia Engineering, 2014
AbstractBecause the anisotropy of shale formation should result in that wellbore deviations is unpredictable, the bit-rock interaction should be fully lucubrated in order to eliminate this problem. The impact of shale rock anisotropy and the cutting velocity on the load of PDC cutter wasn’t considered by the existing cutter-rock interaction models.
Jiajun, Wang, Deyong, Zou, Renqing, He
openaire   +2 more sources

Cancer Cells Traverse Faster in Confined Space by Modifying Vimentin filaments With Nuclear Deformation and Promoting the Growth of Desired Tumor Spheroids

open access: yesAdvanced Materials Interfaces, EarlyView.
This study demonstrates how the Vimentin intermediate (VIM) filaments distribution/density regulates the attainment of different migration modes through cytoskeleton rearrangement and controls the nuclear morphology in migrating cells under physical confinement, which facilitates the faster traversing of those cells and the growth of post‐migration ...
Md Kowsar Alam   +4 more
wiley   +1 more source

Numerical Simulation on Cutting and Breaking of Heterogeneous Conglomerate by Special-Shaped PDC Cutter

open access: yesShiyou jixie
When the PDC bit is used to drill conglomerate formations, the frequent impact loads reduce the expected life of PDC cutter, leading to frequent bit changes and ultimately affecting drilling efficiency.
Shi Jiangang   +5 more
doaj   +1 more source

Single‐Cell Profiling Across Immune Tissues and Organs Reveals Immunosenescence Signatures in Male Rhesus Monkeys

open access: yesAdvanced Science, EarlyView.
Single‐cell profiling across bone marrow, spleen, mesenteric lymph, and blood in rhesus monkeys reveals organ Immunosenescence. GZMB rises with age, particularly in cytotoxic and terminally exhausted CD8+ T cells, and BHLHE40 emerges as a key transcription factor enriched across multiple CD8+ subsets, regulating pro‐inflammatory and exhaustion‐related ...
Shengnan Wang   +10 more
wiley   +1 more source

THE ANALYSIS OF PDC CUTTER CHARACTERISTIC IN HARD FORMATION DRILLING RELATING TO WEAR (BACK & SIDE RAKE ANGLE) [PDF]

open access: yes, 2015
The project focuses on the optimization of Polycrystalline Diamond Compact (PDC) cutters characteristic features relating to wear for improvement on durability in drilling of hard formation.
Nasir Gathoth Subroto, Affan
core  

Irradiated Tumor Cell‐Derived Microparticles Activate Systemic Anti‐Tumor Immunity via the STING/NLRP3/GSDMD Axis in Neutrophils

open access: yesAdvanced Science, EarlyView.
Radiotherapy induces tumor cells to release microparticles (RT‐MPs) into the circulation. The mitochondrial DNA carried by these RT‐MPs activates the STING/NLRP3/GSDMD axis in splenic neutrophils, triggering IL‐1β secretion. This, in turn, enhances dendritic cell function and facilitates the formation of cytotoxic T lymphocytes, thereby promoting ...
Yan Hu   +18 more
wiley   +1 more source

Conversion of Transplanted Mature Hepatocytes into Afp+ Reprogrammed Cells for Liver Regeneration After Injury

open access: yesAdvanced Science, EarlyView.
Donor‐derived tdTomato+ mature hepatocytes were FACS‐isolated and transplanted into Fah−/− host mice. During regeneration, these cells convert into proliferative, unipotent Afp+ rHeps. Their plasticity is governed by a PPARγ/AFP‐dependent metabolic switch, segregating into pro‐proliferative Afplow and pro‐survival Afphigh subpopulations.
Ting Fang   +12 more
wiley   +1 more source

An Experimental and Numerical Simulation Study on Rock Cutting Based on Pre-Breaking

open access: yesShiyou jixie, 2019
The design of the mixed-cutter placement can only rely on the engineering experience. The combination of experiment and numerical simulation is used to study the rock breaking force and rock breaking efficiency of the PDC cutter under different pre ...
Liu Zhong, Hou Huihui, Hu Wei
doaj  

Targeting WTAP/ROR1/WNT5A‐Mediated Crosstalk Between Glioma Stem Cells and Macrophages to Normalize Tumor Vasculature and Enhance Chemotherapy

open access: yesAdvanced Science, EarlyView.
In hypoxic microenvironment, WNT5A is predominantly secreted by tumor‐associated macrophages. Hypoxia‐induced WTAP mediates ROR1 stability by m6A modifications in a HuR‐dependent manner in Glioma stem cells (GSCs). WNT5A activates the WNT pathway via ROR1 binding on GSCs, driving glioma‐derived endothelial cells (GDECs) differentiation.
Xiaoyong Chen   +15 more
wiley   +1 more source

ABAQUS-Based Parameterized Cutter Layout and Rock Breaking Simulation of PDC Bits

open access: yesShiyou jixie, 2020
In recent years, structures and types of PDC bits undergone significant changes, which puts forward higher requirements on cutter layout design. As reasonable cutter layout is the key to ensure the drilling life of PDC bits, a parameterized cutter layout
吴泽兵   +4 more
doaj  

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