Results 21 to 30 of about 12,266 (204)
Use of the KlADH3 promoter for the quantitative production of the murine PDE5A isoforms in the yeast Kluyveromyces lactis [PDF]
, 2017 Background: Phosphodiesterases (PDE) are a superfamily of enzymes that hydrolyse cyclic nucleotides (cAMP/ cGMP), signal molecules in transduction pathways regulating crucial aspects of cell life.
Biagioni, Stefano +5 more
core +1 more source
Phosphodiesterase Type 5 Inhibitors, Sport and Doping [PDF]
, 2017 Phosphodiesterase type 5 inhibitors (PDE5i) (e.g., sildenafil, tadalafil, vardenafil, and avanafil) are drugs commonly used to treat erectile dysfunction, pulmonary arterial hypertension, and benign prostatic hyperplasia.
Borrione, Paolo +8 more
core +1 more source
Evolution of phosphodiesterase type 5 inhibitors in treatment of erectile dysfunction in Taiwan
Urological Science, 2016 Erectile dysfunction (ED) is a prevalent form of male sexual dysfunction. Phosphodiesterase type 5 (PDE5) inhibitor is the first-line treatment for ED. Numerous well-designed and -conducted clinical trials and postmarketing studies have established the ...
Bang-Ping Jiann
doaj +1 more source
Management of erectile dysfunction post-radical prostatectomy [PDF]
, 2014 © 2015 Saleh et al.Radical prostatectomy is a commonly performed procedure for the treatment of localized prostate cancer. One of the long-term complications is erectile dysfunction.
Abboudi, H +4 more
core +1 more source
Mechanisms involved in the remyelinating effect of sildenafil [PDF]
, 2018 Remyelination occurs in demyelinated lesions in multiple sclerosis (MS) and pharmacological treatments that enhance this process will critically impact the long term functional outcome in the disease.
Díaz-Lucena, Daniela +5 more
core +1 more source
PDE5 inhibitors and permanent visual loss [PDF]
International Journal of Impotence Research, 2005 Nonarteritic anterior ischemic optic neuropathy (NAION), a form of optic nerve stroke, has received attention as the result of a possible rare association with PDE5 inhibitors (PDE5i). The possible mechanism of the PDE5i interaction with NAION is unclear, and the sporadic case reports do not seem to shed light on this topic. There is little guidance on
openaire +2 more sources
Journal of Enzyme Inhibition and Medicinal Chemistry, 2017 The essential biological function of phosphodiesterase (PDE) type enzymes is to regulate the cytoplasmic levels of intracellular second messengers, 3′,5′-cyclic guanosine monophosphate (cGMP) and/or 3′,5′-cyclic adenosine monophosphate (cAMP).
Gülru Kayık +2 more
doaj +1 more source
Frontiers in Oncology, 2019 Human castration-resistant prostate cancer (CRPC) is a significant target of clinical research. The use of DNA-damaging agents has a long history in cancer chemotherapy but is limited by their toxicities.
Jo-Fan Chang +10 more
doaj +1 more source
Journal of Medical Internet Research, 2023 BackgroundPatient medication reviews on social networking sites provide valuable insights into the experiences and sentiments of individuals taking specific medications.
Youran Noh, Maryanne Kim, Song Hee Hong
doaj +1 more source
PDE5 Inhibitors in Non-Urological Conditions
Current Pharmaceutical Design, 2009 Phosphodiesterase type-5 (PDE5) inhibitors are widely used as first-line therapy for erectile dysfunction (ED). Their efficacy and safety combined with an increasing understanding of cyclic guanosine monophosphate (cGMP)-regulated mechanisms, have triggered a number of attempts to determine their effects and potential benefits in non-urological ...
Vlachopoulos, C. +4 more
openaire +3 more sources