Results 1 to 10 of about 3,797 (199)

CORRECTION CHRONIC ISCHEMIA FINITE COMBINATION OF VARDENAFIL AND PENTOXIFYLLINE EXPERIMENT

Кубанский научный медицинский вестник, 2016
Experimental work conducted on Wistar rat line. Ischemia was simulated on the shin muscles of rats. Muscle ischaemia correction performed intragastric administration of pentoxifylline at a dose of 60 mg / kg of vardenafil dose of 0.9 mg / kg daily for 28
K. I. Lavrinenko, A. S. Belous, G. S. Mal, E. B. Artyushkova, E. A. Loyko   +4 more
doaj   +2 more sources

Effect of vardenafil on diabetic foot ulcer (DFU) in rats

Zagazig Journal of Pharmaceutical Sciences, 2018
The present study was designed to investigate the possible effect of vardenafil phosphodiesterase-5 inhibitor on diabetic foot ulcer induced in rats and the underlying mechanism(s).
Hany Anwer , Waleed Barakat , Mona F Mahmoud   +2 more
doaj   +2 more sources

Experimental substantiation of an opportunity of the use of vardenafil for pharmacological preconditioning in surgery

Кубанский научный медицинский вестник, 2015
The possibility of vardenafil using for pharmacological preconditioning in surgery is studied. Experiment was carried out on Wistar rats. The influence of vardenafil on the survival of pedicled isolated skin flap and the state of the microvasculature in ...
I. M. Kolesnik, M. V. Pokrovskiy, V. A. Lasarenko   +2 more
doaj   +2 more sources

REVITALISE: A Large Observational Study Assessing the Safety and Effectiveness of Vardenafil in Men With Erectile Dysfunction and Metabolic Syndrome

Sexual Medicine, 2016
Introduction: Erectile dysfunction (ED) is prevalent in men with metabolic syndrome (MetS); therefore, it is important to characterize ED treatments in this population.
Ridwan Shabsigh, MD, FACS, Andreas Mattern, PhD   +1 more
doaj   +1 more source

Counterfeiting honey with phosphodiesterase inhibitors for sexual activity enhancement: detection using high-performance liquid chromatography coupled with a photodiode array detector (HPLC-PAD) [PDF]

Journal of Men's Health
Globally, there have been several reports of natural products contaminated with illegal adulterants that threaten consumer health because of their adverse pharmacological effects.
Abdullah M. Alkhalaf, Fouza K. Alenazi, Mubarak M. Abudahash, Reem Alfadhli, Ghadah H. Altoum, Naif D. Alenzi   +5 more
doaj   +1 more source

Phosphodiesterase type 5 inhibitors increase Herceptin transport and treatment efficacy in mouse metastatic brain tumor models. [PDF]

PLoS ONE, 2010
Chemotherapeutic drugs and newly developed therapeutic monoclonal antibodies are adequately delivered to most solid and systemic tumors. However, drug delivery into primary brain tumors and metastases is impeded by the blood-brain tumor barrier (BTB ...
Jinwei Hu, Julia Y Ljubimova, Satoshi Inoue, Bindu Konda, Rameshwar Patil, Hui Ding, Andres Espinoza, Kolja A Wawrowsky, Chirag Patil, Alexander V Ljubimov, Keith L Black   +10 more
doaj   +1 more source

Ciprofloxacin-Induced Antibacterial Activity Is Attenuated by Phosphodiesterase Inhibitors

Current Therapeutic Research, 2015
Background: Ciprofloxacin is a commonly used antibiotic for urinary tract infection that interacts with bacterial topoisomerases leading to oxidative radicals generation and bacterial cell death.
Majed M. Masadeh, PhD, Karem H. Alzoubi, PhD, Omar F. Khabour, Sayer I. Al-Azzam, Msc   +3 more
doaj   +1 more source

Phosphodiesterase 5 Inhibitor Potentiates Epigallocatechin 3-O-Gallate-Induced Apoptotic Cell Death via Activation of the cGMP Signaling Pathway in Caco-2 Cells

Current Issues in Molecular Biology, 2022
Epigallocatechin 3-O-gallate (EGCG) is a predominant component in green tea with various health benefits. The 67 kDa laminin receptor (67LR) is a nonintegrin cell surface receptor that is overexpressed in various types of cancer; 67LR was identified a ...
Jaehoon Bae, Kwanwoo Lee, Ji-Sun Park, Jinseok Jung, Hirofumi Tachibana, Yoshinori Fujimura, Motofumi Kumazoe, Jae Sung Lim, Young-Chang Cho, Seung-Jae Lee, Su-Jin Park   +10 more
doaj   +1 more source

Phosphodiesterase-5 inhibitors for erectile dysfunction in patients with diabetes mellitus: A systematic review and meta-analysis of randomized controlled trials

Indian Journal of Endocrinology and Metabolism, 2015
Background and Aims: Patients with diabetes mellitus frequently experience erectile dysfunction. This systematic review and meta-analysis were conducted to find efficacy and tolerability of phosphodiesterase 5 (PDE5) inhibitors in patients with diabetes ...
Yatan Pal Singh Balhara, Siddharth Sarkar, Rishab Gupta   +2 more
doaj   +1 more source

Optimization of the Factors Affecting the Absorption of Vardenafil from Oral Disintegrating Tablets: A Clinical Pharmacokinetic Investigation

Pharmaceutics, 2019
Because of poor solubility and considerable metabolism, vardenafil (VRD) bioavailability is 15%. To overcome this obstacle, this study aimed to increase the solubility, hasten the onset of action, and mask the unpleasant taste of VRD utilizing &beta ...
Hytham A. Al-Gethmy, Usama A. Fahmy, Nabil A. Alhakamy, Osama A. A. Ahmed, Khalid M. El-Say   +4 more
doaj   +1 more source