Heliyon, 2023 Background: A novel vardenafil analogue was detected from a health wine claimed to be anti-impotence during a special inspection in an online store. Methods: The unknown compound was found by using ultra-high performance liquid chromatography coupled to ...
Qing Hu
exaly +4 more sources
Vardenafil Reduces Testicular Damage Following Ischemia/Reperfusion Injury in Rats
Kaohsiung Journal of Medical Sciences, 2009 We investigated the effect of intraperitoneal vardenafil (1 mg/kg) administration during an ischemic period in a rat model of testicular torsion/detorsion (T/D). Twenty-one adult Wistar rats were equally randomized into a control group, a T/D group and a
Bulent Erol +2 more
exaly +4 more sources
The phosphodiesterase-5 inhibitor vardenafil is a potent inhibitor of ABCB1/P-glycoprotein transporter. [PDF]
PLoS ONE, 2011 One of the major causes of chemotherapy failure in cancer treatment is multidrug resistance (MDR) which is mediated by the ABCB1/P-glycoprotein. Previously, through the use of an extensive screening process, we found that vardenafil, a phosphodiesterase ...
Pei-Rong Ding +12 more
doaj +2 more sources
Vardenafil Enhances Oxytocin Expression in the Paraventricular Nucleus without Sexual Stimulation [PDF]
International Neurourology Journal, 2010 PurposeOxytocin is associated with the ability to form normal social attachments. c-Fos is an immediate early gene whose expression is used as a marker for stimulus-induced changes in neurons.
Mal Soon Shin +9 more
doaj +2 more sources
Vardenafil Activity in Lung Fibrosis and In Vitro Synergy with Nintedanib
Cells, 2021 Idiopathic pulmonary fibrosis (IPF) remains an intractably fatal disorder, despite the recent advent of anti-fibrotic medication. Successful treatment of IPF, like many chronic diseases, may benefit from the concurrent use of multiple agents that exhibit
Michael H. Bourne +5 more
doaj +2 more sources
Physiologically Based Pharmacokinetic Modeling for Predicting Drug Levels After Bariatric Surgery: Vardenafil Exposure Before vs. After Gastric Sleeve/Bypass [PDF]
BiomoleculesBariatric surgery involves major changes in the anatomy and physiology of the gastrointestinal tract, which may alter oral drug bioavailability and efficacy. Phosphodiesterase-5 inhibitor (PDE5i) drugs are the first-line treatment of erectile dysfunction,
Daniel Porat +3 more
doaj +2 more sources
Vardenafil and Tamsulosin in the Management of Ureteral Stent–Related Symptoms: A Prospective Comparative Study [PDF]
Urology Research and PracticeObjective: This study aimed to compare the effectiveness of vardenafil, a phosphodi esterase-5 inhibitor, and tamsulosin, an alpha-blocker, in the management of ureteral srtent–elated symptoms. Methods: A total of 208 patients who underwent ureteric
Ahmed Abdellatif +4 more
doaj +2 more sources
Acute Effects of Vardenafil on Pulmonary Artery Responsiveness in Pulmonary Hypertension [PDF]
The Scientific World Journal, 2012 Phosphodiesterase type-5 (PDE-5) inhibitors are novel and important options for the treatment of pulmonary arterial hypertension (PAH). Therefore, we aimed to examine effects of vardenafil, a PDE-5 inhibitor, on the pulmonary arteries isolated from rats ...
Edibe Karasu-Minareci +3 more
doaj +2 more sources
The effects of vardenafil and pentoxifylline administration in an animal model of ischemic colitis [PDF]
Clinics, 2014 OBJECTIVES: Vardenafil enhances dilatation of vascular smooth muscle and inhibits platelet aggregation. The purpose of this study was to evaluate the clinical effects of vardenafil and pentoxifylline administration in an experimental model of ischemic ...
Mehmet Aziret +10 more
doaj +2 more sources
Biology Open, 2020 Cystic fibrosis (CF) is a genetic disease characterized by progressive lung and chronic digestive manifestations. We have shown that therapeutic doses of vardenafil, a phosphodiesterase type 5 (PDE5) inhibitor, corrects CF Transmembrane conductance ...
Barbara Dhooghe +7 more
doaj +2 more sources