Results 151 to 160 of about 4,222 (186)
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Low expression of PDHA1 predicts poor prognosis in gastric cancer
Pathology Research and Practice, 2019PDH E1 component subunit alpha (PDHA1) has been reported to be biologically significant in several human tumors. The aim of this study was to investigate the expression of PDHA1 in gastric cancer (GC) and its relationship with clinicopathological characteristics and prognosis. Oncomine analysis of neoplastic vs.
Xinghua Zhu, Lei Yang
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SHP2 regulates adipose maintenance and adipocyte-pancreatic cancer cell crosstalk via PDHA1
Journal of Cell Communication and Signaling, 2022 AbstractAdipocytes are the most abundant cell type in the adipose tissue, and their dysfunction is a significant driver of obesity-related pathologies, such as cancer. The mechanisms that (1) drive the maintenance and secretory activity of adipocytes and (2) mediate the cancer cellular response to the adipocyte-derived factors are not fully understood.
Mariana Tannus Rückert +2 more
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A putative exonic splicing enhancer in exon 7 of thePDHA1 gene affects splicing of adjacent exons
Human Mutation, 2008 A nonsense mutation (c.729C>A, Y243X) in exon 7 of the PDHA1 gene in a patient with pyruvate dehydrogenase deficiency results in aberrant splicing of the primary transcript with production of stable mRNAs which lack either both exons 6 and 7 or exon 7 ...
R M Brown, G K Brown, Robyn M Brown
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miR‑21‑5p targets PDHA1 to regulate glycolysis and cancer progression in gastric cancer
Oncology Reports, 2018 Pyruvate dehydrogenase A1 (PDHA1) is a component of the pyruvate dehydrogenase enzyme complex, which links glycolysis and the tricarboxylic acid cycle, and is important for cancer metabolism shift. PDHA1 downregulation has been revealed in several types of cancer to enhance glycolysis.
Xuedong Fang
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Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 2022
Deficiency of the pyruvate dehydrogenase complex E1-alpha subunit is a rare genetic disease with X-linked dominant inheritance. The clinical spectrum of the disease is extremely wide: from lethal forms in children of the first year of life with lactic acidosis to chronic neurological manifestations with structural changes in the central nervous system ...
D.S. Razheva +2 more
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Deficiency of the pyruvate dehydrogenase complex E1-alpha subunit is a rare genetic disease with X-linked dominant inheritance. The clinical spectrum of the disease is extremely wide: from lethal forms in children of the first year of life with lactic acidosis to chronic neurological manifestations with structural changes in the central nervous system ...
D.S. Razheva +2 more
openaire +2 more sources
Alteration of mitochondrial protein PDHA1 in Lewy body disease and PARK14
Biochemical and Biophysical Research Communications, 2017The histopathological hallmark of Parkinson's disease (PD) and dementia with Lewy bodies (DLB) is the occurrence of insoluble fibrillary aggregates known as Lewy bodies. Mitochondria play a vital role in energy production, and the pathogenesis of PD is associated with altered cellular metabolism due to mitochondrial dysfunction.
Yasuo Miki +5 more
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Four novel PDHA1 mutations in pyruvate dehydrogenase deficiency
Journal of Inherited Metabolic Disease, 2009SummaryThe pyruvate dehydrogenase (PDH) complex is a mitochondrial multienzyme that catalyses the irreversible oxidative decarboxylation of pyruvate to acetyl‐CoA. We report four novel PDHA1 mutations in patients with pyruvate dehydrogenase deficiency.
E, Ostergaard +8 more
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Refined localization of the pyruvate dehydrogenase E1α gene (PDHA1) by linkage analysis
Human Genetics, 1996Pyruvate dehydrogenase (PDH) E1 alpha is a key component in the PDH complex which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA. Defects in the gene coding for PDH E1 alpha (PDHA1) are associated with a variety of clinical symptoms, often of a severe character.
Børglum, A D +3 more
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